|
Glioma
|
|
0.030 |
GeneticVariation
|
BEFREE |
This meta-analysis suggests that glioma susceptibility is associated with rs1799782 and rs25487 of X-ray repair complementing defective repair in Chinese hamster cells 1 (XRCC1), rs1805377 of XRCC4, rs1800067 of excision repair cross-complementing rodent repair deficiency complementation group 4 (ERCC4) and rs3212986 of ERCC1 in Asian population, and rs12917 of O-6-methylguanine-DNA methyltransferase (MGMT) and rs1136410 of poly(ADP-ribose) polymerase 1 (PARP1) in Caucasian population.
|
27055523 |
2017 |
|
Glioma
|
|
0.030 |
GeneticVariation
|
BEFREE |
However, no association was found between variants of LIG4 rs1805388, XRCC4 rs2075685 and XRCC4 rs1805377 and development of glioma.
|
25973104 |
2015 |
|
Malignant neoplasm of urinary bladder
|
|
0.030 |
GeneticVariation
|
BEFREE |
In addition, significant association was maintained in prostate cancer (rs28360071), lung cancer (rs6869366) and bladder cancer (rs1805377) subgroups analysis.
|
23321468 |
2013 |
|
Glioma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Interestingly, we detected a significant additive and multiplicative interaction effect between the LIG4 rs1805388 and XRCC4 rs1805377 polymorphisms with an increasing risk of gliomas.
|
23663450 |
2013 |
|
Carcinoma of bladder
|
|
0.030 |
GeneticVariation
|
BEFREE |
In addition, significant association was maintained in prostate cancer (rs28360071), lung cancer (rs6869366) and bladder cancer (rs1805377) subgroups analysis.
|
23321468 |
2013 |
|
Carcinoma of bladder
|
|
0.030 |
GeneticVariation
|
BEFREE |
The study was designed to examine the polymorphisms associated with two genes namely XRCC4 G1394T (rs6869366), intron 3 (rs28360317), intron 7 rs1805377 and rs2836007 and XRCC3 (rs861539 and rs1799796), respectively and investigate their role as susceptible markers for UBC risk in North Indian cohort.
|
21617942 |
2012 |
|
Malignant neoplasm of urinary bladder
|
|
0.030 |
GeneticVariation
|
BEFREE |
The study was designed to examine the polymorphisms associated with two genes namely XRCC4 G1394T (rs6869366), intron 3 (rs28360317), intron 7 rs1805377 and rs2836007 and XRCC3 (rs861539 and rs1799796), respectively and investigate their role as susceptible markers for UBC risk in North Indian cohort.
|
21617942 |
2012 |
|
Carcinoma of bladder
|
|
0.030 |
GeneticVariation
|
BEFREE |
Carriers of a putative functional SNP in intron 7 of XRCC4 (rs1,805,377) had significantly increased bladder cancer risk compared with common homozygotes: 1.33 (1.08-1.64) per variant allele.
|
17557904 |
2007 |
|
Malignant neoplasm of urinary bladder
|
|
0.030 |
GeneticVariation
|
BEFREE |
Carriers of a putative functional SNP in intron 7 of XRCC4 (rs1,805,377) had significantly increased bladder cancer risk compared with common homozygotes: 1.33 (1.08-1.64) per variant allele.
|
17557904 |
2007 |
|
Liver carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
With TaqMan real-time PCR, the results showed that no significant association between XRCC4 (rs1</span>805377) and ATF6 (rs2070150) and risk of HCC in the Thai population.
|
26925648 |
2016 |
|
Breast Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Genotypes in XRCC4 were associated with BC risk, with ORs of 1.67 (95 % CI 1.01-2.76) for the combined GA/AA of rs1805377 and 1.69 (95 % CI 1.03-2.77) for rs1056503 TG/GG; these associations were no longer statistically significant in multivariable conditional logistic regression models.
|
24062231 |
2013 |
|
Bladder Neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
In addition, significant association was maintained in prostate cancer (rs28360071), lung cancer (rs6869366) and bladder cancer (rs1805377) subgroups analysis.
|
23321468 |
2013 |
|
Malignant neoplasm of breast
|
|
0.020 |
GeneticVariation
|
BEFREE |
Genotypes in XRCC4 were associated with BC risk, with ORs of 1.67 (95 % CI 1.01-2.76) for the combined GA/AA of rs1805377 and 1.69 (95 % CI 1.03-2.77) for rs1056503 TG/GG; these associations were no longer statistically significant in multivariable conditional logistic regression models.
|
24062231 |
2013 |
|
Liver carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The SNP of XRCC4 rs1805377 was significantly associated with decreased risk of HCC development (OR, 0.592; p=0.028) and improved overall survival of patients with HCC (median survival time (MST) of 48, 72, and 89 months for the AA, AG, and GG genotypes, respectively; p=0.044).
|
22659345 |
2012 |
|
Malignant neoplasm of breast
|
|
0.020 |
GeneticVariation
|
BEFREE |
However, rs1805377 (A>G), rs1056503 (G>T), rs28360317 (ins>del) and rs3734091 (A>G) polymorphisms of XRCC4 gene did not appear to have an influence on breast cancer susceptibility.
|
22994773 |
2012 |
|
Breast Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
However, rs1805377 (A>G), rs1056503 (G>T), rs28360317 (ins>del) and rs3734091 (A>G) polymorphisms of XRCC4 gene did not appear to have an influence on breast cancer susceptibility.
|
22994773 |
2012 |
|
Lip and Oral Cavity Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
In this hospital-based case-control study, the association of XRCC4 codon 247 (rs3734091), G-1394T (rs6869366), intron 7 (rs28360317) and intron 7 (rs1805377) polymorphisms with oral cancer risk in a Central Taiwanese population was investigated.
|
18630527 |
2008 |
|
Malignant neoplasm of mouth
|
|
0.020 |
GeneticVariation
|
BEFREE |
In this hospital-based case-control study, the association of XRCC4 G-1394T (rs6869366), intron 3 (rs28360071), intron 7 (rs28360317), and intron 7 (rs1805377) polymorphisms with oral cancer risk in a Taiwanese population was first investigated.
|
18164646 |
2008 |
|
Malignant neoplasm of mouth
|
|
0.020 |
GeneticVariation
|
BEFREE |
In this hospital-based case-control study, the association of XRCC4 codon 247 (rs3734091), G-1394T (rs6869366), intron 7 (rs28360317) and intron 7 (rs1805377) polymorphisms with oral cancer risk in a Central Taiwanese population was investigated.
|
18630527 |
2008 |
|
Lip and Oral Cavity Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
In this hospital-based case-control study, the association of XRCC4 G-1394T (rs6869366), intron 3 (rs28360071), intron 7 (rs28360317), and intron 7 (rs1805377) polymorphisms with oral cancer risk in a Taiwanese population was first investigated.
|
18164646 |
2008 |
|
Bladder Neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
Carriers of a putative functional SNP in intron 7 of XRCC4 (rs1,805,377) had significantly increased bladder cancer risk compared with common homozygotes: 1.33 (1.08-1.64) per variant allele.
|
17557904 |
2007 |
|
Complete atrioventricular block
|
|
0.010 |
GeneticVariation
|
BEFREE |
The present study was conducted to evaluate any association between SNP frequencies in two genes, XRCC4 (rs1805377) and ATF6 (rs2070150), and the risk of CHB and HCC development in Thai patients.
|
26925648 |
2016 |
|
Hepatitis B
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genetic Variations in XRCC4 (rs1805377) and ATF6 (rs2070150) are not Associated with Hepatocellular Carcinoma in Thai Patients with Hepatitis B Virus Infection.
|
26925648 |
2016 |
|
Squamous cell carcinoma of esophagus
|
|
0.010 |
GeneticVariation
|
BEFREE |
As for XRCC4 (rs1805377) polymorphism, no difference was found in distribution between the ESCC and control groups.
|
26166223 |
2016 |
|
Lymphoma, Follicular
|
|
0.010 |
GeneticVariation
|
BEFREE |
The following genotypes in combination with hair dye use before 1980 were associated with FL risk: BRCA2 rs144848 AC+CC [odds ratio (OR) (95% confidence interval (CI)) 3.28(1.27-8.50)], WRN rs1346044 TT [OR(95% CI) 2.70(1.30-5.65)], XRCC3 rs861539 CT+TT [OR(95% CI) 2.76(1.32-5.77)], XRCC4 rs1805377 GG [OR(95% CI) 2.07(1.10-3.90)] and rs1056503 TT [OR(95% CI) 2.17(1.16-4.07)], ERCC1 rs3212961 CC [OR(95% CI) 1.93(1.00-3.72)], RAD23B rs1805329 CC [OR(95% CI) 2.28(1.12-4.64)], and MGMT rs12917 CC, rs2308321 AA, and rs2308327 AA genotypes [OR(95% CI) 1.96(1.06-3.63), 2.02(1.09-3.75), and 2.23(1.16-4.29), respectively].
|
25178586 |
2014 |