Neural Tube Defects
|
|
0.030 |
GeneticVariation
|
BEFREE |
Still, the influence of the 1420 C>T polymorphism of the cSHMT gene on the folate-related risk of NTD needs further investigation.
|
11386852 |
2001 |
Adult Acute Lymphocytic Leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
Polymorphisms in methionine synthase (MS A2756G), cytosolic serine hydroxymethyltransferase (SHMT1 C1420T), and a double (2R2R) or triple (3R3R) 28-bp tandem repeat in the promoter region of thymidylate synthase (TS) were studied and found to modulate ALL risk.
|
11986237 |
2002 |
Adult Acute Lymphocytic Leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
Polymorphisms in thymidylate synthase (TS) 28-bp tandem repeats in the promoter region and in cytosolic serine hydroxymethyltransferase (SHMT1 C1420T) have been reported to modulate the risk of adult acute lymphocytic leukemia (ALL).
|
12604405 |
2003 |
Lymphoma, Non-Hodgkin
|
|
0.020 |
GeneticVariation
|
BEFREE |
The polymorphisms examined and haplotypes generated included thymidylate synthase (TYMS 28-bp triple repeat [3R]-->double repeat [2R], 1494del6, IVS6 -68C>T, 1122A>G, and 1053C>T); 5,10-methylenetetrahydrofolate reductase (MTHFR 677C>T and 1298A>C); serine hydroxymethyltransferase (SHMT1 C1420T); reduced folate carrier (RFC G80A); and methionine synthase (MTR A2756G), making the present study the largest and most comprehensive to date to evaluate associations between genetic polymorphisms in folatemetabolizing genes and NHL risk.
|
15198953 |
2004 |
Cardiovascular Diseases
|
|
0.020 |
GeneticVariation
|
BEFREE |
Plasma total homocysteine concentrations were highest in the subgroup of me</span>n with both polymorphisms, MTHFR 677C-->T TT and cSHMT 1420C-->T TT, consistent with a higher risk of CVD in this subgroup.
|
16046727 |
2005 |
Adenoma of large intestine
|
|
0.010 |
GeneticVariation
|
BEFREE |
In a case-control study, including 768 cases and 709 controls, we investigated the associations between colorectal adenomas and TS tandem repeat and SHMT1 C1420T polymorphisms, and the interplay with B-vitamins.
|
17113224 |
2007 |
Carcinogenesis
|
|
0.020 |
GeneticVariation
|
BEFREE |
To assess the association between the C to T transition in the methylenetetrahydro folate reductase gene (MTHFR C677T) and the C to T transition in the serine hydroxymethyltransferase ( 1 )gene (SHMT ( 1 ) C1420T) and the increased risk of carcinogenesis of esophageal squamous cell carcinoma (ESCC) and gastric cardia adenocarcinoma (GCA) in a population of high incident region of Northern China.
|
17206530 |
2007 |
Extrapulmonary Small Cell Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association of MTHFR C677T and SHMT(1) C1420T with susceptibility to ESCC and GCA in a high incident region of Northern China.
|
17206530 |
2007 |
Gastric Cardia Adenocarcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
To assess the association between the C to T transition in the methylenetetrahydro folate reductase gene (MTHFR C677T) and the C to T transition in the serine hydroxymethyltransferase ( 1 )gene (SHMT ( 1 ) C1420T) and the increased risk of carcinogenesis of esophageal squamous cell carcinoma (ESCC) and gastric cardia adenocarcinoma (GCA) in a population of high incident region of Northern China.
|
17206530 |
2007 |
Giant Cell Arteritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The association between the MTHFR C677T and SHMT ( 1 ) C1420T polymorphisms and the risk of ESCC and GCA was demonstrated.
|
17206530 |
2007 |
Squamous cell carcinoma of esophagus
|
|
0.010 |
GeneticVariation
|
BEFREE |
The association between the MTHFR C677T and SHMT ( 1 ) C1420T polymorphisms and the risk of ESCC and GCA was demonstrated.
|
17206530 |
2007 |
Autistic Disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
MTHFR C677T is a risk factor, whereas MTRR A66G and SHMT C1420T polymorphisms reduce risk for autism.
|
19440165 |
2009 |
Breast Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
A nested case-control study within the Nurses' Health Study was used to investigate an association between cSHMT (1420C --> T) and breast cancer risk.
|
19707223 |
2010 |
Malignant neoplasm of breast
|
|
0.040 |
GeneticVariation
|
BEFREE |
A nested case-control study within the Nurses' Health Study was used to investigate an association between cSHMT (1420C --> T) and breast cancer risk.
|
19707223 |
2010 |
Malignant neoplasm of prostate
|
|
0.020 |
GeneticVariation
|
BEFREE |
Vitamin B(12), holo-haptocorrin, and the folate-pathway single-nucleotide polymorphisms MTR 2756A>G and SHMT1 1420C>T have been associated with an increased risk of prostate cancer.
|
20852008 |
2010 |
Prostate carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Vitamin B(12), holo-haptocorrin, and the folate-pathway single-nucleotide polymorphisms MTR 2756A>G and SHMT1 1420C>T have been associated with an increased risk of prostate cancer.
|
20852008 |
2010 |
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association between rectal or colon cancer risk and serine hydroxymethyltransferase 1 (SHMT1) C1420T or methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms was assessed.
|
20920350 |
2010 |
Malignant tumor of colon
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association between rectal or colon cancer risk and serine hydroxymethyltransferase 1 (SHMT1) C1420T or methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms was assessed.
|
20920350 |
2010 |
Cardiovascular Diseases
|
|
0.020 |
GeneticVariation
|
BEFREE |
In the Health Professionals Follow-Up Study, the MTHFR rs1801133 genotype was not associated with CVD risk, nor was there an interaction with SHMT1 rs1979277.
|
21178087 |
2011 |
Down Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, the SHMT C1420T polymorphism (rs1979277) does not affect the concentration of metabolites of folate pathway in our DS mothers.
|
21687976 |
2012 |
Complete Trisomy 21 Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, the SHMT C1420T polymorphism (rs1979277) does not affect the concentration of metabolites of folate pathway in our DS mothers.
|
21687976 |
2012 |
Squamous cell carcinoma of the head and neck
|
|
0.010 |
GeneticVariation
|
BEFREE |
We conducted a case-control study (265 HNSCC cases and 466 non-cancer controls) to investigate associations of MTHFR C677T and A1298C, MTR A2756G, MTRR A66G, RFC1 A80G, MTHFD1 G1958A, CBS 844ins68, TC2 C776G and A67G, SHMT C1420T and BHMT G742A polymorphisms with HNSCC risk.
|
22051736 |
2012 |
Malignant neoplasm of breast
|
|
0.040 |
GeneticVariation
|
BEFREE |
Conversely, for women over 50, the risk of breast cancer development was statistically associated with the MTHFR 677CT genotype, but especially significant was risk associated with the presence of the polymorphic allele of cSHMT C1420T (P = 0.0120) and the protective effect associated with the RFC1 G80A polymorphism allele (P = 0.0021), was restrict to this age group.
|
22134752 |
2012 |
Breast Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Conversely, for women over 50, the risk of breast cancer development was statistically associated with the MTHFR 677CT genotype, but especially significant was risk associated with the presence of the polymorphic allele of cSHMT C1420T (P = 0.0120) and the protective effect associated with the RFC1 G80A polymorphism allele (P = 0.0021), was restrict to this age group.
|
22134752 |
2012 |
Coronary Artery Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
In view of growing body of evidence favouring the association of aberrations in one-carbon metabolism and oxidative stress in the aetiology of coronary artery disease (CAD), we investigated the risk associated with polymorphisms regulating the folate uptake and transport such as the glutamate carboxypeptidase II (GCPII) C1561T, reduced folate carrier 1 (RFC1) G80A and cytosolic serine hydroxymethyltransferase (cSHMT) C1420T.
|
22147344 |
2013 |