|
Adult Acute Lymphocytic Leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
Children with ALL (n = 96) were screened for GCPII C1561T, RFC1 G80A, cSHMT C1420T, TYMS 5´-UTR 2R3R, TYMS 3´-UTR ins6/del6, MTHFR C677T, MTR A2756G polymorphisms using PCR-RFLP and PCR-amplified fragment length polymorphism techniques.
|
22838948 |
2012 |
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.020 |
GeneticVariation
|
BEFREE |
Children with ALL (n = 96) were screened for GCPII C1561T, RFC1 G80A, cSHMT C1420T, TYMS 5´-UTR 2R3R, TYMS 3´-UTR ins6/del6, MTHFR C677T, MTR A2756G polymorphisms using PCR-RFLP and PCR-amplified fragment length polymorphism techniques.
|
22838948 |
2012 |
|
Acute lymphocytic leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Children with ALL (n = 96) were screened for GCPII C1561T, RFC1 G80A, cSHMT C1420T, TYMS 5´-UTR 2R3R, TYMS 3´-UTR ins6/del6, MTHFR C677T, MTR A2756G polymorphisms using PCR-RFLP and PCR-amplified fragment length polymorphism techniques.
|
22838948 |
2012 |
|
Colorectal Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
In the overall analysis, association was lacking between the C1420T polymorphism and CRC risk (odds ratio [OR] 0.96-1.04, p = 0.47-0.77), materially unchanged when reanalyzed without the Hardy-Weinberg equilibrium-deviating studies (OR 1.03-1.09, p = 0.22-0.55) or subjected to outlier treatment (OR 0.89-0.99, p = 0.10-0.8).
|
23322534 |
2013 |
|
Colorectal Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Results for other variants varied across individual studies; in our meta-analyses we observed some evidence for SHMT 1420C>T (rs1979277) ((odds ratio) OR = 0.85; 95% confidence interval (CI) = 0.73-1.00 for TT v. CC) and TYMS 5' 28 bp repeat (rs34743033) and CRC risk (OR = 0.84; 95% CI = 0.75-0.94 for 2R/3R v. 3R/3R and OR = 0.82; 95% CI = 0.69-0.98 for 2R/2R v. 3R/3R).
|
23401104 |
2013 |
|
Malignant neoplasm of prostate
|
|
0.020 |
GeneticVariation
|
BEFREE |
In a meta-analysis of folate-pathway polymorphisms, MTR 2756A > G (eight studies, OR = 1.06; 95% CI 1.00, 1.12; P = 0.06) and SHMT1 1420C > T (two studies, OR = 1.11; 95% CI 1.00, 1.22; P = 0.05) were positively associated with prostate cancer risk.
|
23724740 |
2013 |
|
Prostate carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
In a meta-analysis of folate-pathway polymorphisms, MTR 2756A > G (eight studies, OR = 1.06; 95% CI 1.00, 1.12; P = 0.06) and SHMT1 1420C > T (two studies, OR = 1.11; 95% CI 1.00, 1.22; P = 0.05) were positively associated with prostate cancer risk.
|
23724740 |
2013 |
|
Carcinogenesis
|
|
0.020 |
GeneticVariation
|
BEFREE |
DNMT3B C46359T and SHMT1 C1420T polymorphisms in the folate pathway in carcinogenesis of head and neck.
|
24362509 |
2014 |
|
Head and Neck Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
SHMT1 C1420T and DNMT3B C46359T polymorphisms are not associated with HNC development in Brazilian population, however, SHMT1 C1420T polymorphism is less frequent in patients with primary site of tumor in larynx and more frequent in individuals who consume tobacco and alcohol together.
|
24362509 |
2014 |
|
Laryngeal Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
SHMT1 C1420T and DNMT3B C46359T polymorphisms are not associated with HNC development in Brazilian population, however, SHMT1 C1420T polymorphism is less frequent in patients with primary site of tumor in larynx and more frequent in individuals who consume tobacco and alcohol together.
|
24362509 |
2014 |
|
Malignant Head and Neck Neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
SHMT1 C1420T and DNMT3B C46359T polymorphisms are not associated with HNC development in Brazilian population, however, SHMT1 C1420T polymorphism is less frequent in patients with primary site of tumor in larynx and more frequent in individuals who consume tobacco and alcohol together.
|
24362509 |
2014 |
|
Laryngeal neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
SHMT1 C1420T polymorphism was associated with larynx tumor (OR 0.48; 95 % CI 0.27-0.86; P < 0.05).
|
24362509 |
2014 |
|
Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
SHMT1 C1420T and DNMT3B C46359T polymorphisms are not associated with HNC development in Brazilian population, however, SHMT1 C1420T polymorphism is less frequent in patients with primary site of tumor in larynx and more frequent in individuals who consume tobacco and alcohol together.
|
24362509 |
2014 |
|
Primary malignant neoplasm
|
|
0.040 |
GeneticVariation
|
BEFREE |
In summary, the findings suggest that SHMT1 C1420T polymorphism is not associated with overall cancer development, but might decrease cancer susceptibility of Asians as well as reduce leukemia risk.
|
24716966 |
2014 |
|
Malignant Neoplasms
|
|
0.040 |
GeneticVariation
|
BEFREE |
In summary, the findings suggest that SHMT1 C1420T polymorphism is not associated with overall cancer development, but might decrease cancer susceptibility of Asians as well as reduce leukemia risk.
|
24716966 |
2014 |
|
Childhood Leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
In summary, the findings suggest that SHMT1 C1420T polymorphism is not associated with overall cancer development, but might decrease cancer susceptibility of Asians as well as reduce leukemia risk.
|
24716966 |
2014 |
|
leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
In summary, the findings suggest that SHMT1 C1420T polymorphism is not associated with overall cancer development, but might decrease cancer susceptibility of Asians as well as reduce leukemia risk.
|
24716966 |
2014 |
|
Breast Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our meta-analysis failed to detect association between SH</span>MT1 C1420T polymorphism and breast cancer risk.
|
24789272 |
2014 |
|
Malignant neoplasm of breast
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our meta-analysis failed to detect association between SH</span>MT1 C1420T polymorphism and breast cancer risk.
|
24789272 |
2014 |
|
Malignant Neoplasms
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our results indicate that the SHMT1 C1420T polymorphism do not have a significant association with the risk of cancer overall.
|
25194438 |
2014 |
|
Primary malignant neoplasm
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our results indicate that the SHMT1 C1420T polymorphism do not have a significant association with the risk of cancer overall.
|
25194438 |
2014 |
|
Colorectal Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Otherwise, SHMT1 C1420T polymorphism may have a protective effect on colorectal cancer and Asian population.
|
25194438 |
2014 |
|
Malignant neoplasm of colon and/or rectum
|
|
0.010 |
GeneticVariation
|
BEFREE |
Otherwise, SHMT1 C1420T polymorphism may have a protective effect on colorectal cancer and Asian population.
|
25194438 |
2014 |
|
Liver carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Results showed that six SNPs (MTHFR rs1801133, MTRR rs2287780, MTRR rs10380, FTHFD rs1127717, GART rs8971, and SHMT rs1979277) were significantly associated with HCC risk in Chinese population, with P values range from 2.26 × 10(-4) to 0.035).
|
25318605 |
2015 |
|
Parkinson Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Gene-gene interactions within one-carbon metabolic pathway were observed in CAD (GCPII 1561 C>T, SHMT 1420 C>T and MTHFR 677 C>T) and PD (cSHMT 1420 C>T, MTRR 66 A>G and RFC1 80 G>A).
|
25648260 |
2015 |