|
Breast Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Findings of the present study supports that the Pro10Leu, rs1982073, or rs1800470 SNP in <i>TGF-β1</i> is found to be expressed significantly more in GBM patients as it was found in breast cancer.
|
31160907 |
2019 |
|
Malignant neoplasm of breast
|
|
0.030 |
GeneticVariation
|
BEFREE |
Findings of the present study supports that the Pro10Leu, rs1982073, or rs1800470 SNP in <i>TGF-β1</i> is found to be expressed significantly more in GBM patients as it was found in breast cancer.
|
31160907 |
2019 |
|
Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
Moreover, the stratified analyses by tumor HPV status indicated that the significant effects of <i>TGFβ1</i> rs1982073 polymorphism on survival were found among HPV16-positive SCCOP patients only.
|
29463556 |
2018 |
|
Chronic Obstructive Airway Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
In conclusion, this meta-analysis showed that the C allele of rs1982073 was protective against COPD in Caucasians but not in Asians, whereas there was no association of rs1800469, rs2241712, rs6957, and rs2241718 with COPD.
|
28784933 |
2017 |
|
Malignant neoplasm of breast
|
|
0.030 |
GeneticVariation
|
BEFREE |
Confirmed BC risk SNPs rs17468277 (CASP8), rs1982073 (TGFB1), rs2981582 (FGFR2), rs13281615 (8q24), rs3817198 (LSP1), rs889312 (MAP3K1), rs3803662 (TOX3), rs13387042 (2q35), rs4973768 (SLC4A7), rs6504950 (COX11) and rs10941679 (5p12) were genotyped for 25 853 BC patients with the available follow-up; 62 other SNPs, which have been suggested as BC risk SNPs by a GWAS or as candidate SNPs from individual studies, were genotyped for replication purposes in subsets of these patients.
|
22532573 |
2012 |
|
Breast Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Confirmed BC risk SNPs rs17468277 (CASP8), rs1982073 (TGFB1), rs2981582 (FGFR2), rs13281615 (8q24), rs3817198 (LSP1), rs889312 (MAP3K1), rs3803662 (TOX3), rs13387042 (2q35), rs4973768 (SLC4A7), rs6504950 (COX11) and rs10941679 (5p12) were genotyped for 25 853 BC patients with the available follow-up; 62 other SNPs, which have been suggested as BC risk SNPs by a GWAS or as candidate SNPs from individual studies, were genotyped for replication purposes in subsets of these patients.
|
22532573 |
2012 |
|
Chronic Obstructive Airway Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
The results showed that there was no significant association between an increased risk of COPD in carriers of the T allele (TT+TC) versus the CC genotype in rs1800469 and rs1982073.
|
21556788 |
2011 |
|
Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
The two candidate loci, CASP8 (rs1045485, rs17468277) and TGFB1 (rs1982073), were most strongly related with the risk of PR negative tumors (P = 5.1 × 10(-6) and P = 4.1 × 10(-4), respectively), as previously suggested.
|
21596841 |
2011 |
|
Malignant neoplasm of breast
|
|
0.030 |
GeneticVariation
|
BEFREE |
Therefore, the SNPs of TGFB1 rs1982073 and FGFR2 rs1219648 may contribute to the identification of patients with more aggressive breast cancers among Han women in North China.
|
20640597 |
2011 |
|
Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
Tumor subtype analyses indicated that the TGFB1 rs1982073 association may be confined to increased risk of developing progesterone receptor negative (PR(-)) tumors [1.18 (95% CI: 1.09-1.28), 4.1 × 10(-5) (P value for heterogeneity of ORs by PR status = 2.3 × 10(-4))].
|
21527583 |
2011 |
|
Breast Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
In this study, we evaluated the association of the SNP rs1982073 (Leu10Pro) in transforming growth factor-beta 1 (TGFB1) gene and the SNP rs1219648 in fibroblast growth factor receptor 2 (FGFR2) gene with the risk and aggressiveness of breast cancer among women of Han nationality in North China.
|
20640597 |
2011 |
|
Chronic Obstructive Airway Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Among smokers in the COPD cases and control subjects, two SNPs in the promoter region of TGFB1 (rs2241712 and rs1800469) and one SNP in exon 1 of TGFB1 (rs1982073) were significantly associated with COPD (P</=0.02 in all cases).
|
15175276 |
2004 |
|
Carcinoma of lung
|
|
0.020 |
GeneticVariation
|
BEFREE |
The TGF-β1 T + 869C (rs1982073) and C-509T (rs1800469) polymorphisms are not implicated in lung cancer susceptibility in the overall population.
|
31764821 |
2019 |
|
Coronary heart disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
TGFβ1 gene SNP rs1982073 might be correlated with CHD susceptibility, and the T allele might decrease the disease risk.
|
30321660 |
2019 |
|
Primary malignant neoplasm of lung
|
|
0.020 |
GeneticVariation
|
BEFREE |
The TGF-β1 T + 869C (rs1982073) and C-509T (rs1800469) polymorphisms are not implicated in lung cancer susceptibility in the overall population.
|
31764821 |
2019 |
|
Malignant neoplasm of lung
|
|
0.020 |
GeneticVariation
|
BEFREE |
The TGF-β1 T + 869C (rs1982073) and C-509T (rs1800469) polymorphisms are not implicated in lung cancer susceptibility in the overall population.
|
31764821 |
2019 |
|
Pneumonitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
TGF-β1 rs1982073 polymorphism contributes to radiation pneumonitis in lung cancer patients: a meta-analysis.
|
27470220 |
2016 |
|
Carcinoma of lung
|
|
0.020 |
GeneticVariation
|
BEFREE |
TGF-β1 rs1982073 polymorphism contributes to radiation pneumonitis in lung cancer patients: a meta-analysis.
|
27470220 |
2016 |
|
Primary malignant neoplasm of lung
|
|
0.020 |
GeneticVariation
|
BEFREE |
TGF-β1 rs1982073 polymorphism contributes to radiation pneumonitis in lung cancer patients: a meta-analysis.
|
27470220 |
2016 |
|
Malignant neoplasm of lung
|
|
0.020 |
GeneticVariation
|
BEFREE |
TGF-β1 rs1982073 polymorphism contributes to radiation pneumonitis in lung cancer patients: a meta-analysis.
|
27470220 |
2016 |
|
Non-Small Cell Lung Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
TGFβ1 genotypes at rs1800469 and rs1982073 could be useful for predicting DMFS among patients with NSCLC treated with definitive radiation therapy.
|
23840350 |
2013 |
|
Coronary heart disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Minor allele carriers of two genetic variants (rs1800469 and rs1982073) in TGFB1 have a 15% increased risk of CHD.
|
22607024 |
2012 |
|
Asthma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Proposed test statistics are applied to NHANES III data to test for associations between the locus ADRB2 (rs1042713) and obesity, between VDR (rs2239185) and high blood lead level, and between TGFB1 (rs1982073) and asthma.
|
19745160 |
2010 |
|
Non-Small Cell Lung Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results showed that CT/CC genotypes of TGFbeta1 rs1982073:T869C gene were associated with lower risk of RP in patients with NSCLC treated with definitive radio(chemo)therapy and thus may serve as a reliable predictor of RP.
|
19380441 |
2009 |
|
Asthma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The T allele of a coding SNP (rs1982073) was associated with a reduced risk of asthma exacerbations in Costa Rica (P = 0.009) and CAMP (P = 0.005).
|
19096005 |
2009 |