rs201058276, F7

N. diseases: 11
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.050 GeneticVariation BEFREE Contribution of coagulation factor VII R353Q, -323P0/10 and HVR4 polymorphisms to coronary artery disease in Tunisians. 22932775 2013
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.050 GeneticVariation BEFREE The -323Ins10 polymorphism in factor VII gene is significantly associated with CHD in both Asian and European populations, while R353Q polymorphism showed trend for association with CHD in Asians. 21838885 2011
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.050 GeneticVariation BEFREE The influence of functional polymorphisms in the FVII gene (-670A>C, -402G>A, -401G>T and R353Q) and of established cardiovascular risk factors on plasma concentrations of FVII were investigated in a representative sample of middle-aged women with (n=238) and without (n=220) coronary heart disease (CHD). 15711754 2005
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.050 GeneticVariation BEFREE Coagulation factor VII, R353Q polymorphism, and serum choline-containing phospholipids in males at high risk for coronary heart disease. 15081566 2004
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.050 GeneticVariation BEFREE Plasminogen activator inhibitor-1 4G/5G promoter polymorphism and coagulation factor VII Arg353-->Gln polymorphism in Korean patients with coronary artery disease. 10803689 2000
Coronary Artery Disease
CUI: C1956346
Disease: Coronary Artery Disease
0.030 GeneticVariation BEFREE Contribution of coagulation factor VII R353Q, -323P0/10 and HVR4 polymorphisms to coronary artery disease in Tunisians. 22932775 2013
Coronary Arteriosclerosis
CUI: C0010054
Disease: Coronary Arteriosclerosis
0.030 GeneticVariation BEFREE Contribution of coagulation factor VII R353Q, -323P0/10 and HVR4 polymorphisms to coronary artery disease in Tunisians. 22932775 2013
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.030 GeneticVariation BEFREE The presence of the Gln allele in the Arg353Gln polymorphism in the FVII locus did not differ between patients and control individuals but was associated with lower plasma levels of FVIIag and FVIIa that could have a protective effect against myocardial infarction. 17581323 2007
Coronary Arteriosclerosis
CUI: C0010054
Disease: Coronary Arteriosclerosis
0.030 GeneticVariation BEFREE Coagulation factor VII, R353Q polymorphism, and serum choline-containing phospholipids in males at high risk for coronary heart disease. 15081566 2004
Coronary Artery Disease
CUI: C1956346
Disease: Coronary Artery Disease
0.030 GeneticVariation BEFREE Coagulation factor VII, R353Q polymorphism, and serum choline-containing phospholipids in males at high risk for coronary heart disease. 15081566 2004
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.030 GeneticVariation BEFREE No significant associations between the R353Q polymorphism and MI, CVD, or diabetes were observed, although the polymorphism strongly influenced plasma levels of FVII. 15081566 2004
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.030 GeneticVariation BEFREE In order to determine the role of two polymorphisms in the factor VII gene (R353Q and intron 7 hypervariable region) in the susceptibility to develop early myocardial infarction, a total of 175 patients with acute myocardial infarction aged 50 years or less (mean age 41+/-7 years) and 200 controls (average age 42+/-6) without cardiovascular disease were genotyped for these polymorphisms. 11578716 2001
Coronary Arteriosclerosis
CUI: C0010054
Disease: Coronary Arteriosclerosis
0.030 GeneticVariation BEFREE Plasminogen activator inhibitor-1 4G/5G promoter polymorphism and coagulation factor VII Arg353-->Gln polymorphism in Korean patients with coronary artery disease. 10803689 2000
Coronary Artery Disease
CUI: C1956346
Disease: Coronary Artery Disease
0.030 GeneticVariation BEFREE In conclusion, the 4G/5G PAI-1 promoter polymorphism and Arg353-->Gln FVII polymorphism are not major genetic risk factors for CAD in Koreans. 10803689 2000
Cardiovascular Diseases
CUI: C0007222
Disease: Cardiovascular Diseases
0.020 GeneticVariation BEFREE To examine the R353Q polymorphism of the FVII gene and the relation to myocardial infarction (MI), cardiovascular disease (CVD), and diabetes, and furthermore, to elucidate the association between the polymorphism and plasma levels of FVII coagulant activity (FVIIc), FVII antigen (FVIIag), activated FVII (FVIIa), and serum choline-containing phospholipids (PC). 15081566 2004
Acute myocardial infarction
CUI: C0155626
Disease: Acute myocardial infarction
0.020 GeneticVariation BEFREE Associations of the known polymorphisms of the coagulation factor VII (FVII) gene (R353Q), the coagulation factor XIII (FXIII) gene (V34L) and the glycoprotein Ia (Gp1a) gene (C807T) with the occurrence of AMI were studied in 142 AMI survivors and 142 age- and sex-matched control subjects. 12486862 2002
Cardiovascular Diseases
CUI: C0007222
Disease: Cardiovascular Diseases
0.020 GeneticVariation BEFREE In order to determine the role of two polymorphisms in the factor VII gene (R353Q and intron 7 hypervariable region) in the susceptibility to develop early myocardial infarction, a total of 175 patients with acute myocardial infarction aged 50 years or less (mean age 41+/-7 years) and 200 controls (average age 42+/-6) without cardiovascular disease were genotyped for these polymorphisms. 11578716 2001
Acute myocardial infarction
CUI: C0155626
Disease: Acute myocardial infarction
0.020 GeneticVariation BEFREE In order to determine the role of two polymorphisms in the factor VII gene (R353Q and intron 7 hypervariable region) in the susceptibility to develop early myocardial infarction, a total of 175 patients with acute myocardial infarction aged 50 years or less (mean age 41+/-7 years) and 200 controls (average age 42+/-6) without cardiovascular disease were genotyped for these polymorphisms. 11578716 2001
Thrombosis of cerebral veins
CUI: C0151945
Disease: Thrombosis of cerebral veins
0.010 GeneticVariation BEFREE Coagulation factor VII R353Q polymorphism and the risk of puerperal cerebral venous thrombosis. 22136731 2012
Vertical Talus
CUI: C0240912
Disease: Vertical Talus
0.010 GeneticVariation BEFREE Our findings suggest that the FVII R353Q polymorphism is not associated with increased risk for CVT occurring during the puerperal period in Indian women. 22136731 2012
Diabetes Mellitus
CUI: C0011849
Disease: Diabetes Mellitus
0.010 GeneticVariation BEFREE To examine the R353Q polymorphism of the FVII gene and the relation to myocardial infarction (MI), cardiovascular disease (CVD), and diabetes, and furthermore, to elucidate the association between the polymorphism and plasma levels of FVII coagulant activity (FVIIc), FVII antigen (FVIIag), activated FVII (FVIIa), and serum choline-containing phospholipids (PC). 15081566 2004
Diabetes
CUI: C0011847
Disease: Diabetes
0.010 GeneticVariation BEFREE To examine the R353Q polymorphism of the FVII gene and the relation to myocardial infarction (MI), cardiovascular disease (CVD), and diabetes, and furthermore, to elucidate the association between the polymorphism and plasma levels of FVII coagulant activity (FVIIc), FVII antigen (FVIIag), activated FVII (FVIIa), and serum choline-containing phospholipids (PC). 15081566 2004
Cerebrovascular accident
CUI: C0038454
Disease: Cerebrovascular accident
0.010 GeneticVariation BEFREE Circulating levels of Factor VII:C are determined by R353Q genotype and cluster with other risk factors associated with insulin resistance in South Asian ischaemic stroke patients, first-degree relatives and control subjects but are not related to stroke or a family history of stroke. 12529745 2002