|
Marijuana Abuse
|
|
0.050 |
GeneticVariation
|
BEFREE |
CNR1 haplotypes were formed from four CNR1 SNPs (rs806368, rs1049353, rs2023239, and rs6454674) and tested with level of cannabis exposure to assess their interactive effects on the lingual gyrus, cingulum (right and left) and rolandic operculum, regions showing cannabis exposure effects in the SPM8 analyses.
|
27500453 |
2016 |
|
Marijuana Abuse
|
|
0.050 |
GeneticVariation
|
BEFREE |
When genotype was considered in the case-control analyses, there was a group by genotype interaction, such that the rs2023239 G allele predicted lower volume of bilateral hippocampi among cannabis users relative to controls (both p<0.001).
|
22669173 |
2012 |
|
Marijuana Abuse
|
|
0.050 |
GeneticVariation
|
BEFREE |
Intriguingly, rs9444584 is in strong linkage disequilibrium with two other SNPs (rs9450898 (r(2) = 0.841) and rs2023239 (r(2) = 0.920)) that have been associated with addiction, obesity (rs2023239), and reduced fronto-temporal white matter volumes in schizophrenia patients as a result of cannabis misuse (rs9450898).
|
22362764 |
2012 |
|
Marijuana Abuse
|
|
0.050 |
GeneticVariation
|
BEFREE |
Between-group comparisons showed that carriers of the CNR1 rs2023239 G allele had significantly greater activity in reward-related areas of the brain, such as the orbitofrontal cortex (OFC), inferior frontal gyrus (IFG), and anterior cingulate gyrus (ACG), during exposure to marijuana cues, as compared with those with the A/A genotype for this SNP.
|
20010552 |
2010 |
|
Marijuana Abuse
|
|
0.050 |
GeneticVariation
|
BEFREE |
Two single nucleotide polymorphisms (SNPs) in the CNR1 (rs2023239) and FAAH (rs324420) genes, associated previously with substance abuse and functional changes in cannabinoid regulation, were examined in a sample of daily marijuana smokers.
|
18705688 |
2008 |
|
Obesity
|
|
0.020 |
GeneticVariation
|
BEFREE |
Intriguingly, rs9444584 is in strong linkage disequilibrium with two other SNPs (rs9450898 (r(2) = 0.841) and rs2023239 (r(2) = 0.920)) that have been associated with addiction, obesity (rs2023239), and reduced fronto-temporal white matter volumes in schizophrenia patients as a result of cannabis misuse (rs9450898).
|
22362764 |
2012 |
|
Obesity
|
|
0.020 |
GeneticVariation
|
BEFREE |
Neither rs2023239 nor rs806381 polymorphism was significantly associated with body mass index-defined overweight and obesity or waist-to-hip-ratio-defined obesity.
|
22244745 |
2012 |
|
Migraine Disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition, AG and GG genotypes of OPRM1 rs1799971 were correlated with migraine episodes, AG and GG of OPRM1 rs1799971, and CT and CC of CNR1 rs806368 with a family history of migraines (second degree relatives), and CT and CC of CNR1 rs2023239 with a positive response to therapy.
|
28349993 |
2017 |
|
positive and negative symptoms
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs2023239 variant also was associated with significant improvements in positive and negative symptoms of schizophrenia.
|
26071625 |
2015 |
|
Psychotic Disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
Here, we have tested whether three CNR1 variants (rs1049353, rs1535255 and rs2023239) are associated with changes in brain volumes, body mass index (BMI) or psychopathological scores in a 3-year longitudinal study of 65 first-episode psychosis patients.
|
26071625 |
2015 |
|
Abnormal behavior
|
|
0.010 |
GeneticVariation
|
BEFREE |
Given the preclinical and clinical evidence regarding the associations between cannabinoid systems and both opiate dependence and psychiatric disorders, we chose to address whether one single nucleotide polymorphism (SNP) of the cannabinoid receptor type 1 gene (CNR1) named rs2023239 would be associated with lifetime MDD and SB in a population of opiate-dependent outpatients remitted under stable methadone treatment.
|
26331953 |
2015 |
|
Schizophrenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs2023239 variant also was associated with significant improvements in positive and negative symptoms of schizophrenia.
|
26071625 |
2015 |
|
Mental disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
Given the preclinical and clinical evidence regarding the associations between cannabinoid systems and both opiate dependence and psychiatric disorders, we chose to address whether one single nucleotide polymorphism (SNP) of the cannabinoid receptor type 1 gene (CNR1) named rs2023239 would be associated with lifetime MDD and SB in a population of opiate-dependent outpatients remitted under stable methadone treatment.
|
26331953 |
2015 |
|
Major Depressive Disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
The minor C allele of rs2023239 showed an independent protective effect against lifetime MDD after adjustment for potential confounders.
|
26331953 |
2015 |
|
Nonorganic psychosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Here, we have tested whether three CNR1 variants (rs1049353, rs1535255 and rs2023239) are associated with changes in brain volumes, body mass index (BMI) or psychopathological scores in a 3-year longitudinal study of 65 first-episode psychosis patients.
|
26071625 |
2015 |
|
Metabolic Syndrome X
|
|
0.010 |
GeneticVariation
|
BEFREE |
The minor alleles of rs6928499, rs1535255, and rs2023239 were nominally associated with a lower risk of MetS [odds ratio (OR), 0.56; 95% confidence interval (CI), 0.37-0.84; P = 0.006; OR, 0.56; 95% CI, 0.37-0.84; P = 0.006; and OR, 0.44; 95% CI, 0.27-0.72; P = 0.001, respectively, adjusted for age, sex, duration of illness, clozapine or olanzapine treatment).
|
23422373 |
2013 |
|
Cannabis use
|
|
0.010 |
GeneticVariation
|
BEFREE |
These data replicate previous findings of reduced hippocampal and amygdalar volume among heavy cannabis users, and suggest that CNR1 rs2023239 variation may predispose smaller hippocampal volume after heavy cannabis use.
|
22669173 |
2012 |
|
Overweight and obesity
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, the rs2023239 and rs806381 polymorphisms of CNR1 were not associated with increased overweight and obesity risk.
|
22244745 |
2012 |
|
Addictive Behavior
|
|
0.010 |
GeneticVariation
|
BEFREE |
Intriguingly, rs9444584 is in strong linkage disequilibrium with two other SNPs (rs9450898 (r(2) = 0.841) and rs2023239 (r(2) = 0.920)) that have been associated with addiction, obesity (rs2023239), and reduced fronto-temporal white matter volumes in schizophrenia patients as a result of cannabis misuse (rs9450898).
|
22362764 |
2012 |
|
Cannabis Dependence
|
|
0.010 |
GeneticVariation
|
BEFREE |
A single nucleotide polymorphism in the cannabis receptor-1 gene (CNR1), rs2023239, has been associated with CD diagnosis and intermediate phenotypes, including abstinence-induced withdrawal, cue-elicited craving, and parahippocampal activation to cannabis cues.
|
22669173 |
2012 |
|
Substance abuse problem
|
|
0.010 |
GeneticVariation
|
BEFREE |
Two single nucleotide polymorphisms (SNPs) in the CNR1 (rs2023239) and FAAH (rs324420) genes, associated previously with substance abuse and functional changes in cannabinoid regulation, were examined in a sample of daily marijuana smokers.
|
18705688 |
2008 |
|
Nicotine Dependence
|
|
0.010 |
GeneticVariation
|
BEFREE |
Haplotype 1-1-2 of markers rs2023239-rs12720071-rs806368 was associated with nicotine dependence and FTND score in the 2 samples (P < .001 and P = .009, respectively).
|
18606954 |
2008 |
|
Impulsive Behavior
|
|
0.010 |
GeneticVariation
|
BEFREE |
Impulsivity was significantly associated with the 6-repeat allele of the triplet repeat polymorphism (AATn/A6; p < .0001), as well as four SNPs in or near the CNR1 receptor gene: rs1535255 (p = .001), rs2023239 (p = .004), rs1049353 (p < .001) and rs806368 (p < .0006).
|
18179391 |
2007 |
|
Polysubstance dependence
|
|
0.010 |
GeneticVariation
|
BEFREE |
We examined the association of 4 SNPs (rs6928499, rs806379, rs1535255, rs2023239) in the distal region of intron 2 of CNR1 both with individual substance dependence diagnoses (i.e., alcohol, cocaine, and opioids), as well as with polysubstance dependence.
|
16741937 |
2006 |
|
Substance Dependence
|
|
0.010 |
GeneticVariation
|
BEFREE |
We examined the association of 4 SNPs (rs6928499, rs806379, rs1535255, rs2023239) in the distal region of intron 2 of CNR1 both with individual substance dependence diagnoses (i.e., alcohol, cocaine, and opioids), as well as with polysubstance dependence.
|
16741937 |
2006 |