|
Rheumatoid Arthritis
|
|
0.070 |
GeneticVariation
|
BEFREE |
Our results showed that rs10754558 NLRP3 and rs2043211 CARD8 polymorphisms are associated with RA development (p value = 0.044, OR = 1.77, statistical power = 0.999) and severity measured by Health Assessment Questionnaire (HAQ) (p value = 0.03), respectively.
|
29230505 |
2018 |
|
Rheumatoid Arthritis
|
|
0.070 |
GeneticVariation
|
BEFREE |
NLRP3 p.Q705K and CARD8 p.C10X polymorphisms were not associated with the susceptibility to RA, separately or in combined forms.
|
28185410 |
2017 |
|
Rheumatoid Arthritis
|
|
0.070 |
GeneticVariation
|
BEFREE |
NLRP3-Q705K and CARD8-C10X genotypes were analyzed in relation to CVD by logistic regression, adjusting for traditional risk factors, antirheumatic treatment, and age at the onset of RA.
|
26178285 |
2015 |
|
Crohn Disease
|
|
0.070 |
GeneticVariation
|
BEFREE |
Is the CARD8 rs2043211 polymorphism associated with susceptibility to Crohn's disease? A meta-analysis.
|
26462578 |
2015 |
|
Crohn Disease
|
|
0.070 |
GeneticVariation
|
BEFREE |
Our meta-analysis results indicated significant association between rs2043211 polymorphism and the susceptibility to CD under the dominant model and homozygote contrast in the European population.
|
25564880 |
2015 |
|
Rheumatoid Arthritis
|
|
0.070 |
GeneticVariation
|
BEFREE |
No statistically significant differences in allele or genotype frequencies for the rs2043211 CARD8 gene variant between patients with RA and controls were seen.
|
23088220 |
2013 |
|
Crohn Disease
|
|
0.070 |
GeneticVariation
|
BEFREE |
The p.C10X mutation significantly associated or displayed a trend toward lower ASCA and ALCA levels (p=0.038 and p=0.08, respectively) only in the subgroup of CD probands.
|
23506543 |
2013 |
|
Rheumatoid Arthritis
|
|
0.070 |
GeneticVariation
|
BEFREE |
This study suggests that variations in the innate immunity genes CARD8 (p.C10X) and NLRP3 (p.Q705K) have no effect on RA susceptibility either in the Tunisian or in the French population.
|
22128899 |
2012 |
|
Crohn Disease
|
|
0.070 |
GeneticVariation
|
BEFREE |
To understand the genetic association between CARD8/NALP3 and IBD in Koreans, we investigated seven CARD8, four NALP3 and four NOD2 SNPs in 650 Crohn's disease (CD), 660 ulcerative colitis (UC) patients and 688 controls from the Korean population. rs2043211 of CARD8 showed significant association with UC (P = 0.011; odds ratio = 1.50, 95% confidence intervals = 1.12-2.00, P = 0.006 under recessive model).
|
21248762 |
2011 |
|
Crohn Disease
|
|
0.070 |
GeneticVariation
|
BEFREE |
We found that the presence of the minor allele of rs2043211 with the major allele of rs35829419 conferred a protective effect against Crohn's disease (and vice versa), which intensified in the absence of NOD2 mutations (P(1,2/1,1)=0.009, odds ratio (OR)=0.66, 95% confidence interval (CI) (0.48-0.90); P(1,1/1,2)=0.015, OR=0.35, 95% CI (0.15-0.82)).
|
20182451 |
2010 |
|
Rheumatoid Arthritis
|
|
0.070 |
GeneticVariation
|
BEFREE |
CARD8 p.C10X and NLRP3 p.Q705K genotypes were assessed in >500 controls and patients with early RA from northern Sweden.
|
19443463 |
2010 |
|
Crohn Disease
|
|
0.070 |
GeneticVariation
|
BEFREE |
Our results show that men who have both the C10X and Q705K alleles in CARD8 and NALP3, and who express wild-type alleles of Nod2 are at an increased risk of developing CD (odds ratio, OR: 3.40 range: 1.32-8.76); P = 0.011).
|
19319132 |
2009 |
|
Crohn Disease
|
|
0.070 |
GeneticVariation
|
BEFREE |
Analyzing 3 independent European IBD cohorts, we found no evidence that the C10X variant in CARD8 confers susceptibility for CD.
|
18092344 |
2008 |
|
Rheumatoid Arthritis
|
|
0.070 |
GeneticVariation
|
BEFREE |
We analyzed the p.C10X polymorphism in 200 patients with RA, and found that homozygous carriers of the CARD8-S allele have higher disease activity score (p = 0.014), more extra-articular manifestations (p = 0.03), and a lower probability of clinical remission (p = 0.03) than the CARD8-L allele carriers.
|
17878386 |
2007 |
|
Inflammatory Bowel Diseases
|
|
0.030 |
GeneticVariation
|
BEFREE |
There was no significant association between rs2043211 polymorphism and IBD, CD, and IC in overall population.
|
25564880 |
2015 |
|
Inflammatory Bowel Diseases
|
|
0.030 |
GeneticVariation
|
BEFREE |
To understand the genetic association between CARD8/NALP3 and IBD in Koreans, we investigated seven CARD8, four NALP3 and four NOD2 SNPs in 650 Crohn's disease (CD), 660 ulcerative colitis (UC) patients and 688 controls from the Korean population. rs2043211 of CARD8 showed significant association with UC (P = 0.011; odds ratio = 1.50, 95% confidence intervals = 1.12-2.00, P = 0.006 under recessive model).
|
21248762 |
2011 |
|
Inflammatory Bowel Diseases
|
|
0.030 |
GeneticVariation
|
BEFREE |
However, studies testing for the association of the CARD8 loss-of-function single-nucleotide polymorphism (SNP) rs2043211 with IBD have yielded mixed results.
|
20182451 |
2010 |
|
Ulcerative Colitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
The stop allele of rs2043211 was associated with higher serum interleukin-1β levels only in female patients with UC (P = 0.027).
|
21248762 |
2011 |
|
Ulcerative Colitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
We found neither evidence for genetic interactions between p.C10X and NOD2 nor the C10X variant to be associated with a CD or UC phenotype.
|
18092344 |
2008 |
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, NF-κB-94 ins/del ATTG and CARD8 (rs2043211) genotypes might serve as novel biomarkers and potential targets for ALL.
|
31428046 |
2019 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Investigation of NF-κB-94ins/del ATTG and CARD8 (rs2043211) Gene Polymorphism in Acute Lymphoblastic Leukemia.
|
31428046 |
2019 |
|
Celiac Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
We examined <i>PTPN22</i> rs2476601 (p.Arg620Trp), <i>NLRP3</i> rs35829419 (p.Gln705Lys), and <i>CARD8</i> rs2043211 (p.Cys10Ter) in 66 subjects with coexisting T1D and CD, 65 subjects with T1D who did not develop CD, 67 subjects diagnosed only with CD and 127 healthy unrelated Slovenian individuals.
|
30915320 |
2019 |
|
Acute lymphocytic leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, NF-κB-94 ins/del ATTG and CARD8 (rs2043211) genotypes might serve as novel biomarkers and potential targets for ALL.
|
31428046 |
2019 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
On the other hand, we found no association of <i>NLRP3</i> rs35829419 and <i>CARD8</i> rs2043211 with the development of T1D, CD or both diseases together.
|
30915320 |
2019 |
|
Adult Acute Lymphocytic Leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, NF-κB-94 ins/del ATTG and CARD8 (rs2043211) genotypes might serve as novel biomarkers and potential targets for ALL.
|
31428046 |
2019 |