|
Lupus Erythematosus, Systemic
|
|
0.730 |
GeneticVariation
|
BEFREE |
The IRF5 rs2070197 polymorphism was identified as risk factors for SLE in Caucasian populations (OR 1.82, 95 % CI 1.70-1.96), but it had no effects (monomorphic) in Asians.
|
26233721 |
2015 |
|
Lupus Erythematosus, Systemic
|
|
0.730 |
GeneticVariation
|
BEFREE |
Importantly, our data suggest that in patients with lupus, the presence of the HLA lupus risk alleles in rs1270942 and rs3131379 increases the odds of also carrying the lupus risk allele in IRF5 (rs2070197) by 17% and 16%, respectively (P = 0.0028 and P = 0.0047, respectively).
|
21952918 |
2012 |
|
Lupus Erythematosus, Systemic
|
|
0.730 |
GeneticVariation
|
GWASCAT |
A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus.
|
19838195 |
2009 |
|
Lupus Erythematosus, Systemic
|
|
0.730 |
GeneticVariation
|
BEFREE |
The SNP most strongly associated with SLE was SNP no. rs2070197 (P=5.2x10(-11)), which is a proxy of the risk haplotype, but does not appear to be functional.
|
17393452 |
2007 |
|
SYSTEMIC LUPUS ERYTHEMATOSUS, ASSOCIATION WITH SUSCEPTIBILITY TO, 10
|
|
0.700 |
SusceptibilityMutation
|
CLINVAR |
|
|
|
|
Lupus Erythematosus, Discoid
|
|
0.010 |
GeneticVariation
|
BEFREE |
Importantly, our data suggest that in patients with lupus, the presence of the HLA lupus risk alleles in rs1270942 and rs3131379 increases the odds of also carrying the lupus risk allele in IRF5 (rs2070197) by 17% and 16%, respectively (P = 0.0028 and P = 0.0047, respectively).
|
21952918 |
2012 |
|
Lupus Vulgaris
|
|
0.010 |
GeneticVariation
|
BEFREE |
Importantly, our data suggest that in patients with lupus, the presence of the HLA lupus risk alleles in rs1270942 and rs3131379 increases the odds of also carrying the lupus risk allele in IRF5 (rs2070197) by 17% and 16%, respectively (P = 0.0028 and P = 0.0047, respectively).
|
21952918 |
2012 |
|
Lupus Erythematosus
|
|
0.010 |
GeneticVariation
|
BEFREE |
Importantly, our data suggest that in patients with lupus, the presence of the HLA lupus risk alleles in rs1270942 and rs3131379 increases the odds of also carrying the lupus risk allele in IRF5 (rs2070197) by 17% and 16%, respectively (P = 0.0028 and P = 0.0047, respectively).
|
21952918 |
2012 |
|
Primary Sjögren's syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
No significant association of primary SS with rs2070197, rs10954213, or rs2280714 was seen when they were analyzed independently.
|
18050197 |
2007 |