|
Childhood asthma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the ADEM study, the minor alleles of ADAM33 rs511898 and rs528557 and the ORMDL3/GSDMB rs7216389 polymorphisms were negatively associated, whereas the minor alleles of IL4 rs2243250 and rs2070874 polymorphisms were positively associated with childhood asthma.
|
25768087 |
2015 |
|
Malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
The present study aimed at evaluating the contribution of IL-4 promoter T-1099G (rs2243248), C-589T (rs2243250), C-33T (rs2070874) genetic polymorphisms to the risk of lung cancer in Taiwan.
|
26504066 |
2015 |
|
Leishmaniasis, Visceral
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this study, we aimed to investigate possible association between three functional IL-4 polymorphisms -590C/T (rs2243250), -34C/T (rs2070874) and 70bp VNTR (rs79071878 in intron3) with VL in an Indian cohort comprising of 197 VL patients and 193 healthy controls.
|
25454624 |
2014 |
|
Allergic rhinitis (disorder)
|
|
0.010 |
GeneticVariation
|
BEFREE |
GG/CC/CC and TT/TT/TT (rs2243248, rs2243250, and rs2070874) haplotypes in the IL-4 gene had a significant negative correlation with AR.
|
24075353 |
2014 |
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
To clarify the effects of IL-4 gene polymorphisms on the risk of HBV-related HCC, two common variants, -590C/T (rs2243250) and -33C/T (rs2070874), and their relationship with HBV-related disease risk were investigated in a Chinese population.
|
25295591 |
2014 |
|
Respiration Disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
The most frequent genotypes in the asthma and allergic rhinitis groups were TT for SNP rs2243250, and GG for SNP rs2227284. rs2070874 was not found to be associated with either of the 2 atopic respiratory diseases analyzed in the Pakistani cohort.
|
23654077 |
2013 |
|
Paranoid Schizophrenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of the current case-control study was to examine whether the -590C/T (rs2243250) and -33C/T (rs2070874) IL4 gene polymorphisms are implicated in paranoid schizophrenia development in the Polish population.
|
22528336 |
2012 |
|
Rhinoconjunctivitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
There were no significant relationships between SNP rs2243250, rs2070874, or rs2243290 and rhinoconjunctivitis.
|
22884982 |
2012 |
|
Ischemic stroke
|
|
0.010 |
GeneticVariation
|
BEFREE |
Interleukin-4 (IL4) polymorphisms (rs2243250, rs2070874) were analysed in Korean patients with ischaemic stroke (IS) (n=119) and intracerebral haemorrhage (ICH) (n=79), and age-matched controls (n =267, IS; n=401, ICH) using direct sequencing.
|
21501388 |
2011 |
|
Allergy to penicillin
|
|
0.010 |
GeneticVariation
|
BEFREE |
IL4 single nucleotide polymorphisms (SNPs) rs11740584 (P = .012), rs10062446 (P = .021), and rs2070874 (P = .035) were associated and LACTB SNP rs2729835 (P = .058) was marginally associated with penicillin allergy.
|
18538381 |
2008 |