|
Asthma
|
|
0.050 |
GeneticVariation
|
BEFREE |
IL-4 rs2243250 and rs2070874 allele and genotype frequencies did not significantly differ between the asthma and control groups (P > 0.05), but those of IL-4R rs1801275 did (P < 0.05).
|
27819719 |
2016 |
|
Asthma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Individuals who carried the C allele for rs2070874 of the IL4 gene demonstrated increased asthma risk compared to TT homozygotes.
|
23924473 |
2013 |
|
Asthma
|
|
0.050 |
GeneticVariation
|
BEFREE |
A total of 214 atopic patients (108 with asthma and 106 with allergic rhinitis) and 120 healthy controls from Pakistan were genotyped for IL-4 SNPs C-589T (rs2243250), T+2979G (rs2227284), and C-33T (rs2070874) using restriction fragment length polymorphism-polymerase chain reaction.
|
23654077 |
2013 |
|
Asthma
|
|
0.050 |
GeneticVariation
|
BEFREE |
No evident relationships were found between rs2243250, rs2070874, or rs2227284 and asthma.
|
23964553 |
2013 |
|
Asthma
|
|
0.050 |
GeneticVariation
|
BEFREE |
In the present study, we confirmed the association of rs1800469 in TGF-beta1 and rs20541 in IL-13 with asthma and found a trend toward association between rs2241712 in TGF-beta1 and rs2070874 in IL-4 with asthma among atopic subjects, suggesting TGF-beta1, IL-4 and IL-13 may be associated with the susceptibility and development of asthma in this Chinese population.
|
22053598 |
2011 |
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
In the subgroup analysis by cancer type, rs2243250 polymorphism was demonstrated to be associated with an increased risk of gastric cancer and breast cancer, rs2070874 polymorphism was correlated with leukemia and oral carcinoma, and rs79071878 polymorphism was relevant to bladder carcinoma risk.
|
28656227 |
2017 |
|
Primary malignant neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
In the subgroup analysis by ethnicity, IL‑4 rs2243250 polymorphism was demonstrated to be associated with cancer risk in both Caucasian and Asian populations, rs2070874 was associated with cancer risk in Asian populations, while rs79071878 polymorphism was associated with cancer risk in Caucasian populations.
|
28656227 |
2017 |
|
Respiratory Tract Infections
|
|
0.020 |
GeneticVariation
|
BEFREE |
Association between the TT-genotype of IL-4 rs2070874 polymorphism and a severe phenotype of viral-induced wheeze further underlines the role IL-4 plays in the inflammation pathway leading to viral respiratory infections.
|
28950434 |
2017 |
|
Respiratory Tract Infections
|
|
0.020 |
GeneticVariation
|
BEFREE |
One single-nucleotide polymorphism from IL4 gene was significant for pooled respiratory infections (rs2070874; 1.66 [1.29-2.14]).
|
26524966 |
2015 |
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
The A allele of rs2070874 polymorphism in the IL-4 gene may be a risk factor for cancer development among Caucasians.
|
23572437 |
2013 |
|
Primary malignant neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
The A allele of rs2070874 polymorphism in the IL-4 gene may be a risk factor for cancer development among Caucasians.
|
23572437 |
2013 |
|
Hepatitis B
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our current meta-analysis suggests that rs2243250, rs2070874 and rs2227284 polymorphisms in IL4 gene may play an important role in determining the response to hepatitis B vaccine, especially among Asian populations.
|
23651591 |
2013 |
|
Hepatitis B
|
|
0.020 |
GeneticVariation
|
BEFREE |
SNP rs2070874 was associated with humoral response to hepatitis B vaccine after analyzed by multivariable logistic regression analysis (P=0.015).
|
22824342 |
2012 |
|
Molar Incisor Hypomineralization
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs2070874 SNP (IL4) was also significantly overtransmitted from heterozygous parents with the rs7526319 (TUFT1) and the rs2355767 (BMP2) SNPs, suggesting a synergistic effect of the transmission of these alleles with susceptibility to MIH.
|
30130760 |
2019 |
|
Multiple Sclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The present case-control study inspected the association between seven single nucleotide polymorphisms (SNPs) of IL4 (IL4<sub>-1098</sub>: rs2243248, IL4<sub>-590</sub>: rs2243250, and IL4<sub>-33</sub>: rs2070874), IL4RA (IL4RA<sub>+1902</sub>: rs1801275), and IL10 (IL10<sub>-1082</sub>: rs1800896, IL10<sub>-819</sub>: rs1800871, and IL10<sub>-592</sub>: rs1800872) genes and MS in Iraqi patients.
|
31264107 |
2019 |
|
Carcinoma of bladder
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the subgroup analysis by cancer type, rs2243250 polymorphism was demonstrated to be associated with an increased risk of gastric cancer and breast cancer, rs2070874 polymorphism was correlated with leukemia and oral carcinoma, and rs79071878 polymorphism was relevant to bladder carcinoma risk.
|
28656227 |
2017 |
|
Wheezing
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association between the TT-genotype of IL-4 rs2070874 polymorphism and a severe phenotype of viral-induced wheeze further underlines the role IL-4 plays in the inflammation pathway leading to viral respiratory infections.
|
28950434 |
2017 |
|
Childhood Leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the subgroup analysis by cancer type, rs2243250 polymorphism was demonstrated to be associated with an increased risk of gastric cancer and breast cancer, rs2070874 polymorphism was correlated with leukemia and oral carcinoma, and rs79071878 polymorphism was relevant to bladder carcinoma risk.
|
28656227 |
2017 |
|
Malignant neoplasm of gastrointestinal tract
|
|
0.010 |
GeneticVariation
|
BEFREE |
The IL4 rs2070874 T allele seems to be associated with an increased risk of gastrointestinal cancer (OR 1.11; 95% CI, 1.00-1.24 for T allele vs. C allele).
|
28142034 |
2017 |
|
leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the subgroup analysis by cancer type, rs2243250 polymorphism was demonstrated to be associated with an increased risk of gastric cancer and breast cancer, rs2070874 polymorphism was correlated with leukemia and oral carcinoma, and rs79071878 polymorphism was relevant to bladder carcinoma risk.
|
28656227 |
2017 |
|
Chronic Periodontitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
No significant association between rs2070874 or rs1800925 and CP was found, while the frequencies of rs2243248 and two haplotypes C-G-T and C-T-T showed significant differences between the two groups.
|
27195298 |
2016 |
|
Glioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Nine polymorphisms in genes within the IL-4/IL-13 pathway (IL-4 rs2243250, rs2070874, rs2243248, IL-4R rs1805011, rs1805012, rs1805015, rs1801275, and IL-13 rs20541 and rs1800925) were assessed for their relationship with glioma risk by computing odds ratios (ORs) and corresponding 95 % confidence intervals (CIs).
|
25472582 |
2015 |
|
Primary malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
The present study aimed at evaluating the contribution of IL-4 promoter T-1099G (rs2243248), C-589T (rs2243250), C-33T (rs2070874) genetic polymorphisms to the risk of lung cancer in Taiwan.
|
26504066 |
2015 |
|
Complicated malaria
|
|
0.010 |
GeneticVariation
|
BEFREE |
We have previously found that children heterozygous for IL4 variable-number tandem repeat (VNTR) (rs8179190) or IL4-33 (rs2070874) variants were at risk for severe malaria (SM), whereas homozygous children were protected suggesting a complex genetic control.
|
25935236 |
2015 |
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
The present study aimed at evaluating the contribution of IL-4 promoter T-1099G (rs2243248), C-589T (rs2243250), C-33T (rs2070874) genetic polymorphisms to the risk of lung cancer in Taiwan.
|
26504066 |
2015 |