|
Parkinson Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
We genotyped the single-nucleotide polymorphisms (SNPs) rs2071746 and rs2071747 in HMOX1 and rs1051308 in HMOX2 in 583 Han Chinese with PD and 627 healthy controls using a customized 2×48-Plex SNP Scan™ kit.
|
28179208 |
2017 |
|
Parkinson Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
The four previously reported Parkinson's disease (PD)-related single-nucleotide polymorphisms (SNPs) - rs1775143, rs823114, rs2071746 and rs62063857 - have rarely been studied in Chinese Han populations.
|
28535700 |
2017 |
|
Parkinson Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Subjects carrying both the HO-1 (-413, rs2071746) TT genotype and the GSK3beta (-157, rs6438552) TT genotype had a four times higher risk of developing PD than subjects without these genotypes (adjusted by age and sex OR = 4.12; 95% CI = 1.45-11.71; Bonferroni corrected P = 0.024).
|
20039940 |
2010 |
|
Restless Legs Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
Despite results of several recent case-control association studies which have suggested a possible contribution of heme-oxygenase 1 (HMOX1) rs2071746 and vitamin D3 receptor (VDR) rs731236 variants, or the presence of allele 2 of the complex microsatellite repeat Rep1 within the alpha-synuclein (SNCA) gene promoter in modifying the risk for RLS, these studies need to be replicated in further studies involving different populations.
|
29033051 |
2018 |
|
Essential Tremor
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our group reported decreased risk for ET in carriers of the minor alleles of the rs2071746 and rs1051308 SNPs in the haem-oxygenases 1 and 2 (HMOX1 and HMOX2), respectively, involved in haem metabolism.
|
28276576 |
2017 |
|
Essential Tremor
|
|
0.020 |
GeneticVariation
|
BEFREE |
The present study suggests a weak association between HMOX1 rs2071746 and HMOX2 rs1051308 polymorphisms and the risk to develop ET in the Spanish population.
|
26091465 |
2015 |
|
Restless Legs Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
None of the studied polymorphisms influenced the disease onset, severity of RLS, family history of RLS, serum ferritin levels, or response to dopaminergic agonist, clonazepam or GABAergic drugs.The present study suggests a weak association between HMOX1 rs2071746 polymorphism and the risk to develop RLS in the Spanish population.
|
26313808 |
2015 |
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Combined effect of NQO1-rs1800566, HMOX1-rs2071746, and MT1A-rs11640851 was evaluated on the risks of DM and hypertension.
|
31332605 |
2020 |
|
Anemia, Sickle Cell
|
|
0.010 |
GeneticVariation
|
BEFREE |
HMOX1-413 A>T (rs2071746) polymorphisms might prove to be a prognostic marker among Egyptian SCD, but not CCR5Δ32 (rs333) polymorphisms.
|
31030250 |
2019 |
|
Esophageal Varices
|
|
0.010 |
GeneticVariation
|
BEFREE |
The T allele of heme oxygenase 1 gene SNP polymorphism (rs2071746) is a risk factor for esophageal varices development in cirrhotics.
|
29877949 |
2018 |
|
Cirrhosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Study of the influence of heme oxygenase 1 gene single nucleotide polymorphism (rs2071746) on esophageal varices among patients with cirrhosis.
|
29877949 |
2018 |
|
Liver Cirrhosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Study of the influence of heme oxygenase 1 gene single nucleotide polymorphism (rs2071746) on esophageal varices among patients with cirrhosis.
|
29877949 |
2018 |
|
Inflammatory Bowel Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
The anti-inflammatory genes, haem oxygenase 1 (HO-1, HMOX1) rs2071746 (unrestricted model: p = 9.07 × 10-4; recessive model: p = 4.99 × 10-4; multiplicative model: p = 0.0009; and additive model: p = 1.87 × 10-4) and interleukin-10 (IL-10) rs1800872 (dominant model: p = 0.0277) have been associated with paediatric inflammatory bowel disease.
|
28770550 |
2017 |
|
Coronary Artery Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The genetic mutations within MAPK1 (rs6928, rs9340, rs11913721), HIF-1 (rs1087314, rs2057482), and HO-1 (rs2071746) could alter susceptibility to perimenopausal CAD in this Chinese population.
|
28444966 |
2017 |
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The HMOX1 A-413T (rs2071746) was assessed in relation to risk of colorectal cancer (CRC) and interactions with diet (red meat, fish, fiber, cereals, fruit and vegetables) and lifestyle (use of non-steroidal anti-inflammatory drug and smoking status) were assessed in a case-cohort study of 928 CRC cases and a comparison group of 1726 randomly selected participants from a prospective study of 57,053 persons.
|
25574604 |
2015 |
|
Malignant neoplasm of colon and/or rectum
|
|
0.010 |
GeneticVariation
|
BEFREE |
The HMOX1 A-413T (rs2071746) was assessed in relation to risk of colorectal cancer (CRC) and interactions with diet (red meat, fish, fiber, cereals, fruit and vegetables) and lifestyle (use of non-steroidal anti-inflammatory drug and smoking status) were assessed in a case-cohort study of 928 CRC cases and a comparison group of 1726 randomly selected participants from a prospective study of 57,053 persons.
|
25574604 |
2015 |
|
Arteriosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We undertook this study to investigate whether HO-1 gene rs2071746 polymorphism was associated with clinical outcomes in atherosclerosis ischemic stroke patients.
|
25016572 |
2014 |
|
Atherosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We undertook this study to investigate whether HO-1 gene rs2071746 polymorphism was associated with clinical outcomes in atherosclerosis ischemic stroke patients.
|
25016572 |
2014 |
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, HO-1 gene rs2071746 A allele carrier might be a protective factor for patients with atherosclerotic stroke.
|
25016572 |
2014 |
|
Acute pancreatitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The GT-repeat and SNP rs2071746 were investigated with fluorescence labelled primers and by melting curve analysis in 285 patients with acute pancreatitis, 208 patients with alcoholic CP, 207 patients with idiopathic/hereditary CP, 147 patients with alcoholic liver cirrhosis, and in 289 controls, respectively.
|
22666428 |
2012 |
|
Essential Hypertension
|
|
0.010 |
GeneticVariation
|
BEFREE |
The (GT)n repeat in the HMOX1 promoter showed significant association with EH and BP, whereas SNPs rs2071746 and rs2071749 did not.
|
21275653 |
2011 |
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
In a case-control study of 300 AD patients and 360 healthy controls, we examined whether the combined gene effects between HO-1 (-413, rs2071746) and tau (5' of exon 1, rs242557) polymorphisms might be responsible for susceptibility to AD.
|
18841019 |
2008 |