|
Coronary Artery Disease
|
|
0.720 |
GeneticVariation
|
BEFREE |
A genetic variant c.553G > T (rs2075291) in the apolipoprotein A5 gene is associated with altered triglycerides levels in coronary artery disease (CAD) patients with lipid lowering drug.
|
30606120 |
2019 |
|
Metabolic Syndrome X
|
|
0.720 |
GeneticVariation
|
GWASCAT |
Identification of female-specific genetic variants for metabolic syndrome and its component traits to improve the prediction of metabolic syndrome in females.
|
31170924 |
2019 |
|
Coronary Artery Disease
|
|
0.720 |
GeneticVariation
|
BEFREE |
We identified a missense SNP, rs2075291, in APOA5 associated with CAD</span> at a genome-wide significance level and provided new insights into pathways contributing to the susceptibility to CAD in the multi-ethnic populations from Southeast Asia.
|
29263402 |
2017 |
|
Coronary Artery Disease
|
|
0.720 |
GeneticVariation
|
GWASCAT |
We identified a missense SNP (rs2075291, G > T, G185C) in APOA5 for CAD that reached robust genome-wide significance (Meta P = 7.09 × 10<sup>-10</sup>, OR = 1.636).
|
29263402 |
2017 |
|
Metabolic Syndrome X
|
|
0.720 |
GeneticVariation
|
BEFREE |
It seems that APOA5 rs2075291 could play an important role in triglyceride and HDL-C level in metabolic syndrome affected, while the association of APOA5 rs662799 polymorphism is still under debate.
|
26702748 |
2016 |
|
Metabolic Syndrome X
|
|
0.720 |
GeneticVariation
|
BEFREE |
The chi(2) test and subsequent multivariate logistic regression analysis with adjustment for age, sex and smoking status found that the-3A-->G and 553G-->T (Gly185Cys) polymorphisms of APOA5, the 2052T-->C (Val653Val) and 1866C-->T (Asn591Asn) polymorphisms of LDLR, the 13989A-->G (Ile118Val) polymorphism of CYP3A4 and the 1014T-->A polymorphism of C1QTNF5 were significantly (false discovery rate <0.05) associated with the prevalence of metabolic syndrome, with the variant alleles of APOA5 and C1QTNF5 representing risk factors for and those of LDLR and CYP3A4 being protective against this condition.
|
17766366 |
2008 |
|
High density lipoprotein measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genetic analyses of diverse populations improves discovery for complex traits.
|
31217584 |
2019 |
|
Triglycerides measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
The Korea Biobank Array: Design and Identification of Coding Variants Associated with Blood Biochemical Traits.
|
30718733 |
2019 |
|
Triglycerides measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genetic analyses of diverse populations improves discovery for complex traits.
|
31217584 |
2019 |
|
High density lipoprotein measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
The Korea Biobank Array: Design and Identification of Coding Variants Associated with Blood Biochemical Traits.
|
30718733 |
2019 |
|
High density lipoprotein measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
A large electronic-health-record-based genome-wide study of serum lipids.
|
29507422 |
2018 |
|
Triglycerides measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
A large electronic-health-record-based genome-wide study of serum lipids.
|
29507422 |
2018 |
|
HYPERTRIGLYCERIDEMIA, SUSCEPTIBILITY TO
|
|
0.700 |
SusceptibilityMutation
|
CLINVAR |
|
|
|
|
Hypertriglyceridemia
|
|
0.080 |
GeneticVariation
|
BEFREE |
In summary, magnolol could effectively lower the plasma triglyceride levels in APOA5 c.553G>T variant carrier mice and facilitate the triglyceride metabolism in postprandial hypertriglyceridemia.
|
29425239 |
2018 |
|
Hypertriglyceridemia
|
|
0.080 |
GeneticVariation
|
BEFREE |
The -1131T>C and c.553G>T polymorphisms were associated with hypertriglyceridemia in the study population, but only the -1131T>C polymorphism directly affected apoA5 concentrations.
|
29211729 |
2017 |
|
Hypertriglyceridemia
|
|
0.080 |
GeneticVariation
|
BEFREE |
To measure the correlation between the c.553G>T polymorphism and HTG susceptibility, odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.
|
27813673 |
2016 |
|
Hypertriglyceridemia
|
|
0.080 |
GeneticVariation
|
BEFREE |
Only APOA5 c.553 G ＞ T (rs2075291), resulting in the amino acid mutation Gly185Cys, co-segregated well with hypertriglyceridemia in terms of autosomal recessive inheritance (homozygote TT: mean triglyceride level: 1,071 mg/dL vs non TT (GT and GG): mean triglyceride level: 118 mg/dL; p ＜ 0.001) in the index family.
|
25843152 |
2015 |
|
Hypertriglyceridemia
|
|
0.080 |
GeneticVariation
|
BEFREE |
Aberrant hetero-disulfide bond formation by the hypertriglyceridemia-associated p.Gly185Cys APOA5 variant (rs2075291).
|
25127531 |
2014 |
|
Hypertriglyceridemia
|
|
0.080 |
GeneticVariation
|
BEFREE |
Association of single-nucleotide polymorphism 3 and c.553G>T of APOA5 with hypertriglyceridemia after treatment with highly active antiretroviral therapy containing protease inhibitors in hiv-infected individuals in Taiwan.
|
19187029 |
2009 |
|
Hypertriglyceridemia
|
|
0.080 |
GeneticVariation
|
BEFREE |
The -1131T>C and c.553G>T (G185C) polymorphisms correlated with HTG in this Japanese population, but neither polymorphism directly affected ApoA5 expression.
|
17457003 |
2007 |
|
Hypertriglyceridemia
|
|
0.080 |
GeneticVariation
|
BEFREE |
These findings suggest the possible use of c.553G>T polymorphisms in APOA5 as prognostic indicators for hypertriglyceridemia susceptibility in Chinese.
|
12915450 |
2003 |
|
Arteriosclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results show that two APOA5 variants, rs662799 (-1131T>C) and rs2075291 (c.553G>T), are associated with HDL-cholesterol levels in a Korean population, and suggest that individuals with an APOA5 rs662799 CC genotype are at higher risk of atherosclerosis, particularly when they have low HDL-cholesterol, and this association is related to adiponectin levels.
|
30132804 |
2018 |
|
Atherosclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results show that two APOA5 variants, rs662799 (-1131T>C) and rs2075291 (c.553G>T), are associated with HDL-cholesterol levels in a Korean population, and suggest that individuals with an APOA5 rs662799 CC genotype are at higher risk of atherosclerosis, particularly when they have low HDL-cholesterol, and this association is related to adiponectin levels.
|
30132804 |
2018 |
|
Myocardial Infarction
|
|
0.020 |
GeneticVariation
|
BEFREE |
Minor alleles of three commonly analysed variants within this gene (rs662799, rs3135506, rs2075291) are associated with higher plasma TG values and increased risk of myocardial infarction, with some important interethnic differences observed.
|
27496343 |
2016 |
|
Arteriosclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
We investigated the associations of the APOA5 c.553G>T gene with various metabolic syndrome components and carotid artery atherosclerosis among family members.
|
19665689 |
2009 |