|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The AA genotype of the aging-related single-nucleotide polymorphism (SNP) rs2075650 in TOMM40 has been associated with longevity, while the AG and GG genotypes are associated with an increased risk of Alzheimer's disease.
|
31318836 |
2020 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities.
|
30636644 |
2019 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The SNPs rs2075650 and rs4420638 were linked to the most replications within a single reclassified phenotype or very similar reclassified phenotypes; both were associated with Alzheimer's disease (AD).
|
29942042 |
2019 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Hidden heterogeneity in Alzheimer's disease: Insights from genetic association studies and other analyses.
|
29107063 |
2018 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Minor variants: rs10524523-L, rs4420638-G, rs2075650-G were significantly overrepresented in AD.
|
30443289 |
2018 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
However, Kaplan-Meier survival analyses suggest that AD patients with TOMM40 allele rs2075650-G have an average age of disease onset of 6 years earlier compared with carriers of the A allele.
|
27023435 |
2017 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Collectively, our analysis shows TOMM40 rs2075650 polymorphism is associated with AD susceptibility in Asian, Caucasian, and mixed populations.
|
27328316 |
2016 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Similarly, our evidence suggested that allele A of TOMM40 rs2075650 polymorphism was a risk factor for AD (OR=2.87, 95% CI: 2.46-3.34, P value <0.001).
|
26795201 |
2016 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Both methods' results showed two identical significant SNPs associated with the A β-42 levels in CSF (rs2075650 at intron region TOMM40 with p-value ≥ 1 × 10-16 and rs439401 in the intergenic region of LOC100129500 and APOC1 with p-value ≥ 1 × 10-9) and highlighted APOC1 and TOMM40, which are well-known genes previously associated with AD.
|
26576771 |
2016 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We conclude that rs2075650 in TOMM40 gene may increase the risk of Alzheimer disease.
|
26572157 |
2016 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease.
|
26993346 |
2016 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
In single-SNP based tests, AD risk allele of APOE (rs2075650) was associated with smaller HV (p = 0.0054) and CD33 (rs3865444) with smaller intracranial volume (p = 0.0058).
|
25670335 |
2015 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Overrepresentation of glutamate signaling in Alzheimer's disease: network-based pathway enrichment using meta-analysis of genome-wide association studies.
|
24755620 |
2014 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our prevalent case study comparing prevalent AD cases (n = 428) with participants with no cognitive impairment (n = 524) revealed a significant association of rs6656401 and rs3818361 (CR1), rs2075650 (TOMM40), rs7561528 (BIN1), and rs3865444 (CD33) with late-onset AD that were robust to adjustment with age and apolipoprotein E ε4 genotype.
|
24176626 |
2014 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology.
|
24770881 |
2014 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
GWASCAT |
ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology.
|
24770881 |
2014 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
(2) Four additional AD risk SNPs were nominally associated with obesity (rs17125944 at FERMT2, pBMI = 4.03 × 10(-05), pBMI corr = 2.50 × 10(-03) ; rs3851179 at PICALM; pBMI = 0.002, rs2075650 at TOMM40/APOE, pBMI = 0.024, rs3865444 at CD33, pBMI = 0.024).
|
24788522 |
2014 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
Overrepresentation of glutamate signaling in Alzheimer's disease: network-based pathway enrichment using meta-analysis of genome-wide association studies.
|
24755620 |
2014 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Three SNPs [rs429358 in APOE: odds ratio (OR)=4.24, 95% confidence interval (CI)=3.01-5.96, P=1.23×10; rs2075650 in APOE: OR=3.57, 95% CI=2.51-5.06, P=1.23×10; and rs677909 in PICALM: OR=0.63, 95% CI=0.49-0.81, P=0.00036, log additive model] were significantly associated with AD susceptibility after correction for multiple testing.
|
22975751 |
2014 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
There were four significant associations between genotypes and phenotypes of AD patients: CR1 SNP rs11803956 correlated with Mini-Mental State Examination (MMSE) score (β=1.718, Pcorrected=0.002); ABCA7 SNP rs3752232 correlated with Rey Complex Figure Test (RCFT) copy score (β=-6.861, Pcorrected=0.013); APOE SNP rs2075650 correlated with the percentile of RCFT copy score (β=14.005, Pcorrected=0.021) and the percentile of total score in phonemic fluency (β=11.052, Pcorrected=0.035).
|
24530172 |
2014 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Only TOMM40 rs2075650 showed association with clinical AD after adjusting for APOE-ε4 (p = 0.007), but not after multiple test correction (p>0.05).
|
23573206 |
2013 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recently, the rs2075650 single nucleotide polymorphism in the translocase of outer mitochondrial membrane 40 homolog (TOMM40) gene was identified as a risk factor for AMD and Alzheimer disease.
|
24146538 |
2013 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide association analysis of age-at-onset in Alzheimer's disease.
|
22005931 |
2012 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide association study of Alzheimer's disease with psychotic symptoms.
|
22005930 |
2012 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide association study of Alzheimer's disease.
|
22832961 |
2012 |