|
Crohn Disease
|
|
0.830 |
GeneticVariation
|
BEFREE |
Six single-nucleotide polymorphisms (SNPs) associated with CD were evaluated in these patients: rs2076756, rs2066844, and rs2066845 in NOD2, rs4958847 and rs13361189 in IRGM, and rs2241880 in ATG16L1.
|
31714311 |
2019 |
|
Crohn Disease
|
|
0.830 |
GeneticVariation
|
BEFREE |
The NOD2 single nucleotide polymorphism rs2076756 was associated with younger age at Crohn's disease diagnosis (p = 0.0002).
|
25664710 |
2015 |
|
Crohn Disease
|
|
0.830 |
GeneticVariation
|
GWASCAT |
A genome-wide association study on a southern European population identifies a new Crohn's disease susceptibility locus at RBX1-EP300.
|
22936669 |
2013 |
|
Crohn Disease
|
|
0.830 |
GeneticVariation
|
GWASDB |
A genome-wide association study on a southern European population identifies a new Crohn's disease susceptibility locus at RBX1-EP300.
|
22936669 |
2013 |
|
Crohn Disease
|
|
0.830 |
GeneticVariation
|
GWASDB |
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
|
22412388 |
2012 |
|
Crohn Disease
|
|
0.830 |
GeneticVariation
|
GWASCAT |
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
|
22412388 |
2012 |
|
Crohn Disease
|
|
0.830 |
GeneticVariation
|
GWASDB |
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
|
21102463 |
2010 |
|
Crohn Disease
|
|
0.830 |
GeneticVariation
|
GWASCAT |
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
|
21102463 |
2010 |
|
Crohn Disease
|
|
0.830 |
GeneticVariation
|
BEFREE |
The NOD2 variants rs2066843 and rs2076756 are novel and common CD susceptibility gene variants.
|
21209938 |
2010 |
|
Crohn Disease
|
|
0.830 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis.
|
17435756 |
2007 |
|
Crohn Disease
|
|
0.830 |
GeneticVariation
|
GWASDB |
Systematic association mapping identifies NELL1 as a novel IBD disease gene.
|
17684544 |
2007 |
|
Crohn Disease
|
|
0.830 |
GeneticVariation
|
GWASCAT |
Systematic association mapping identifies NELL1 as a novel IBD disease gene.
|
17684544 |
2007 |
|
Crohn Disease
|
|
0.830 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis.
|
17435756 |
2007 |
|
Crohn Disease
|
|
0.830 |
GeneticVariation
|
GWASDB |
Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci.
|
17804789 |
2007 |
|
Inflammatory Bowel Diseases
|
|
0.820 |
GeneticVariation
|
BEFREE |
The sibling with pouchitis inherited the IBD-associated risk alleles for NOD2 (rs17221417 and rs2076756) from his healthy father.
|
28633443 |
2017 |
|
Inflammatory Bowel Diseases
|
|
0.820 |
GeneticVariation
|
BEFREE |
The aims were to analyze two novel NOD2 variants (rs2066843 and rs2076756) in a large cohort of patients with inflammatory bowel disease and to elucidate phenotypic consequences.
|
21209938 |
2010 |
|
Inflammatory Bowel Diseases
|
|
0.820 |
GeneticVariation
|
GWASDB |
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.
|
17068223 |
2006 |
|
Inflammatory Bowel Diseases
|
|
0.820 |
GeneticVariation
|
GWASCAT |
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.
|
17068223 |
2006 |
|
Pouchitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The sibling with pouchitis inherited the IBD-associated risk alleles for NOD2 (rs17221417 and rs2076756) from his healthy father.
|
28633443 |
2017 |
|
Ulcerative Colitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genomic DNA from 2700 Caucasians including 812 patients with Crohn's disease (CD), 442 patients with ulcerative colitis (UC), and 1446 healthy controls was analyzed for the NOD2 SNPs rs2066843 and rs2076756 and the three main CD-associated NOD2 variants p.Arg702Trp (rs2066844), p.Gly908Arg (rs2066847), and p.Leu1007fsX1008 (rs2066847).
|
21209938 |
2010 |
|
pathologic fistula
|
|
0.010 |
GeneticVariation
|
BEFREE |
In CD patients homozygous for these novel NOD2 variants, genotype-phenotype analysis revealed higher rates of a penetrating phenotype (rs2076756: p = 0.015) and fistulas (rs2076756: p = 0.015) and significant associations with CD-related surgery (rs2076756: p = 0.003; rs2066843: p = 0.015).
|
21209938 |
2010 |