|
Essential Hypertension
|
|
0.040 |
GeneticVariation
|
BEFREE |
Risk genotypes of rs2074192 (TT+CT, OR = 1.72, 95% CI: 1.17-2.53), rs2106809 (TT, OR = 1.71, 95% CI: 1.13-2.58), rs4240157 (CC+CT, OR = 1.99, 95% CI: 1.17-3.41), rs4646155 (TT+CT, OR = 1.94, 95% CI: 1.06-3.54), rs4646188 (TT+CT, OR = 3.25, 95% CI: 1.95-5.41), rs4830542 (CC+CT, OR = 1.88, 95% CI: 1.10-3.23), and rs879922 (CC+CG, OR = 4.86, 95% CI: 2.74-8.64) were associated with EH.
|
30542083 |
2019 |
|
Essential Hypertension
|
|
0.040 |
GeneticVariation
|
BEFREE |
Participants carrying T allele (TT + CT) of rs2074192 (P = 0.006), rs4646155 (P = 0.030) and rs4646188 (P < 0.001), C allele (CT + CT or CC + CG) of rs4240157 (P = 0.012), rs4830542 (P = 0.020) and rs879922 (P < 0.001) and TT genotype of rs2106809 (P = 0.012) were associated with EH.
|
30342552 |
2018 |
|
Essential Hypertension
|
|
0.040 |
GeneticVariation
|
BEFREE |
These results suggest that the ACE2 G8790A and rs2106809 polymorphisms may be associated with EH risk.
|
25237167 |
2015 |
|
Essential Hypertension
|
|
0.040 |
GeneticVariation
|
BEFREE |
Among females, ACE I/D and ACE2 rs2106809 polymorphisms, while among males, ACE2 rs2106809 polymorphism and alcohol consumption are associated with essential hypertension in the study population.
|
24112034 |
2014 |
|
Hypertensive disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
The circulating ACE2 and Ang-(1-7) levels were related to neither rs4646155 nor rs879922 in female or male patients.In conclusion, the rs2106809 polymorphism of the ACE2 gene may be a determinant of the circulating Ang-(1-7) level in female patients with hypertension, suggesting a genetic association between circulating Ang-(1-7) levels and ACE2 gene polymorphisms in patients with hypertension.
|
27310975 |
2016 |
|
Hypertensive disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
ACE2 rs2106809 T allele was found to confer a 1.6-fold risk for hypertension in women (95% confidence interval (CI), 1.132.06), whereas when combined with the effect of the ACE DD genotype, the risk was 2.34-fold (95% CI, 1.754.85) in two independent samples.
|
17473847 |
2007 |
|
Left Ventricular Hypertrophy
|
|
0.010 |
GeneticVariation
|
BEFREE |
ACE2 tagSNPs rs2074192 and rs2106809 as well as major haplotypes CCGC and TCGT may serve as novel risk markers for LVH in hypertensive patients.
|
30917908 |
2019 |
|
Dyslipidemias
|
|
0.010 |
GeneticVariation
|
BEFREE |
Meanwhile,ACE2 SNPs also exhibited association with dyslipidemia but exhibited obvious heterogeneity. rs1978124 (TT + CT, P = 0.009), rs2106809 (TT, P = 0.045), rs233575 (CC + CT, P = 0.018), rs4646188 (CC, P = 0.011) and rs879922 (CC + CG, P = 0.003) were association with increased LDL-C (≥1.8 mmol/L). rs2106809 (CC + CT, P < 0.001), rs2285666(TT + CT, P = 0.017), rs4646142(CC + CG, P = 0.044), rs4646155(TT + CT, P < 0.001) and rs4646188(TT + CT, P = 0.033) were association with decreased HDL-C (< 1.0 mmol/L). rs2074192 (TT + CT, P = 0.012), rs4240157 (CC + CT, P = 0.027), rs4646156 (AA+AT, P = 0.007), rs4646188 (TT + CT, P = 0.005), rs4830542 (CC + CT, P = 0.047) and rs879922 (CC + CG, P = 0.001) were association with increased TC (≥5.2 mmol/L). rs2106809 (P = 0.034) and rs4646188 (P = 0.013) were associated with hypertriglyceridemia.
|
30342552 |
2018 |
|
Ischemic stroke
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the male subgroup, the associations between rs2106809 T male carriers and combined end points including ischemic stroke, heart failure, and death in our study were of significance (OR 3.6, 95% CI 1.0-13.1, P = 0.04).
|
24342297 |
2013 |
|
Lone atrial fibrillation
|
|
0.010 |
GeneticVariation
|
BEFREE |
Lone AF males who carry the rs2106809 T allele are associated with adverse cardiac events.
|
24342297 |
2013 |
|
cardiac event
|
|
0.010 |
GeneticVariation
|
BEFREE |
Lone AF males who carry the rs2106809 T allele are associated with adverse cardiac events.
|
24342297 |
2013 |
|
Hypertrophic Cardiomyopathy
|
|
0.010 |
GeneticVariation
|
BEFREE |
The T allele of rs2106809 and C allele of rs6632677 conferred increasing risk for HCM (OR 1.34, 95% CI 1.01 - 1.77, P = 0.04; OR 1.11, 95% CI 1.03 - 1.21, P = 0.002, respectively), and the 2 single nucleotide polymorphisms (SNPs) were in strong linkage disequilibrium (LD), the TC haplotype was independently associated with a higher OR for HCM (OR = 1.59, 95% CI 1.21 - 1.87) after adjusted for conventional risk factors.
|
18208662 |
2008 |