|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
BEFREE |
Using regression analysis models the rs1004819, rs2201841, and rs10889677 SNPs were found to confer risk for Crohn's disease and ankylosing spondylitis, while rs1343151 had a protective effect in both of these diseases, and the rs2201841 and rs10889677 SNPs showed susceptibility nature for rheumatoid arthritis.
|
23054009 |
2013 |
|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
BEFREE |
Rs1884444 was found to confer risk for UC and psoriasis, rs10889677 for CD and psoriasis, while rs2201841 and rs7517847 had effect only in CD.
|
23093364 |
2013 |
|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
BEFREE |
CD was associated with NOD2 carrier (6.93% CD, 2.15% Controls, P = 0.007), ATG16L1 Thr300Ala (36.1% CD, 29.3% Controls, P = 0.003), SLC22A4 and SLC22A5 (IBD5 locus) functional SNPs (Leu503Phe [10.5% CD, 7.6% Controls, P = 0.05] and g-207c [41.3% CD, 35.7% Controls, P = 0.03], respectively), and IL23R rs2201841 (18.2% CD, 13.8% Controls, P = 0.03), but not IRGM variants, nor three African ancestral NOD2 nonsynonymous variants.IBD5 risk was recessive.
|
22411504 |
2012 |
|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
BEFREE |
The association of ATG16L1 T300A with CD was confirmed [P = 0.004, odds ratio (OR) = 1.69, 95% CI: 1.19-2.41], and both IL23R variants were found to represent significant risk for the disease (P = 0.008, OR = 2.05, 95% CI: 1.20-3.50 for rs1004819 AA; P < 0.001, OR = 2.97, 95% CI: 1.65-5.33 for rs2201841 CC).
|
20066736 |
2010 |
|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
BEFREE |
We observed an increased prevalence of the homozygous rs10889677 AA and homozygous rs2201841 CC genotypes both in the Crohn's disease and in the RA groups as compared to the controls (12.1%, 11.9% vs 5.91%, p<0.05; and 13.2%, 13.1% vs 5.91%, p<0.05), but not in the SSc patients.
|
17606463 |
2008 |
|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
GWASDB |
Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci.
|
17804789 |
2007 |
|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
GWASCAT |
Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci.
|
17804789 |
2007 |
|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
GWASDB |
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.
|
17068223 |
2006 |
|
Psoriasis
|
|
0.830 |
GeneticVariation
|
BEFREE |
Our results suggest that IL-12B (rs3212227) and IL-23R (rs2201841) polymorphisms confer increased risk of psoriasis in our ethnic South Indian Tamils.
|
26472011 |
2016 |
|
Psoriasis
|
|
0.830 |
GeneticVariation
|
BEFREE |
We examined rs2201841 within IL-23R gene in Serbian patients with psoriasis and healthy controls.
|
24910145 |
2014 |
|
Psoriasis
|
|
0.830 |
GeneticVariation
|
BEFREE |
For rs7530511, the pooled ORs were 0.820 (95 % CI 0.764-0.879) for psoriasis and 0.875 (95 % CI 0.766-1.000) for PsA; for rs2201841 the OR was 1.121 (95 % CI 1.031-1.219) for psoriasis.
|
22706445 |
2012 |
|
Psoriasis
|
|
0.830 |
GeneticVariation
|
GWASDB |
Association analyses identify six new psoriasis susceptibility loci in the Chinese population.
|
20953187 |
2010 |
|
Psoriasis
|
|
0.830 |
GeneticVariation
|
GWASCAT |
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.
|
19169254 |
2009 |
|
Psoriasis
|
|
0.830 |
GeneticVariation
|
GWASDB |
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.
|
19169254 |
2009 |
|
Ulcerative Colitis
|
|
0.820 |
GeneticVariation
|
BEFREE |
Stratification by ethnicity revealed that the rs11209026, rs7517847, rs10889677, rs2201841 andrs11465804 polymorphisms were associated with UC in the Caucasian group, but not in Asians, while the rs1004819 and rs11209032 polymorphisms were found to be related to UC for both Caucasian and Asian groups.
|
27902482 |
2017 |
|
Ulcerative Colitis
|
|
0.820 |
GeneticVariation
|
BEFREE |
The IL23R rs2201841 homozygous genotype and IBD5 carrier status together did not confer susceptibility for UC.
|
24415875 |
2014 |
|
Ulcerative Colitis
|
|
0.820 |
GeneticVariation
|
GWASCAT |
Genome-wide association identifies multiple ulcerative colitis susceptibility loci.
|
20228799 |
2010 |
|
Ulcerative Colitis
|
|
0.820 |
GeneticVariation
|
GWASDB |
Genome-wide association identifies multiple ulcerative colitis susceptibility loci.
|
20228799 |
2010 |
|
Multiple Sclerosis
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
|
22190364 |
2011 |
|
Rheumatoid Arthritis
|
|
0.060 |
GeneticVariation
|
BEFREE |
The results of meta-analysis indicated that IL-23R gene rs2201841 polymorphism might be a susceptible factor for RA under G vs. A model, especially in Caucasian population.
|
30942097 |
2019 |
|
Rheumatoid Arthritis
|
|
0.060 |
GeneticVariation
|
BEFREE |
We examined three candidate single nucleotide polymorphisms (SNPs) rs10889677, rs11209026 and rs2201841 of the IL-23R gene, as well as determined their possible association with RA in a Polish population.
|
29370888 |
2018 |
|
Rheumatoid Arthritis
|
|
0.060 |
GeneticVariation
|
BEFREE |
Our data emphasise that the AA genotype of rs11209026 (Arg381Gln) was significantly associated with RA patients compared to the controls (P value=0.001).We did not find any significant association between either rs2201841 or rs10889677 and the development of rheumatoid arthritis (P value=1.000 & 0.562 respectively).
|
25858864 |
2015 |
|
Rheumatoid Arthritis
|
|
0.060 |
GeneticVariation
|
BEFREE |
Using regression analysis models the rs1004819, rs2201841, and rs10889677 SNPs were found to confer risk for Crohn's disease and ankylosing spondylitis, while rs1343151 had a protective effect in both of these diseases, and the rs2201841 and rs10889677 SNPs showed susceptibility nature for rheumatoid arthritis.
|
23054009 |
2013 |
|
Rheumatoid Arthritis
|
|
0.060 |
GeneticVariation
|
BEFREE |
However, no association was found between the IL-23R rs7517847, rs11209026, rs1004819, and rs2201841 polymorphisms and RA susceptibility.
|
23053963 |
2012 |
|
Rheumatoid Arthritis
|
|
0.060 |
GeneticVariation
|
BEFREE |
Logistic regression analysis revealed that bearing these alleles represent risk for the development of rheumatoid arthritis (chi(2) = 5.58, p = 0.018, OR = 2.15, 95% CI 1.14-4.06 for rs10889677; and chi(2) = 7.45, p = 0.006, OR = 2.40, 95% CI 1.28-4.51 for rs2201841).
|
17606463 |
2008 |