|
Schizophrenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The relationship between three polymorphisms (Ala499Val, PAT, and Lys939Gln) of the XPC (MIM: 613208) and the risk of schizophrenia is investigated.
|
30769138 |
2019 |
|
Uterine Fibroids
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, no significant association was observed for leiomyoma risk for rs2228001 A > C. This study indicated that genetic variations in XPC gene are associated with leiomyoma susceptibility in a reproductive women population.
|
31428994 |
2019 |
|
Fibroid Tumor
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, no significant association was observed for leiomyoma risk for rs2228001 A > C. This study indicated that genetic variations in XPC gene are associated with leiomyoma susceptibility in a reproductive women population.
|
31428994 |
2019 |
|
Xeroderma Pigmentosum
|
|
0.010 |
GeneticVariation
|
BEFREE |
The present study has genotyped 334 subjects from North Indian population for xeroderma pigmentosum complementation Group C (XPC) rs2228001A>C, XPC rs77907221 polyadenylate (PAT) deletion/insertion (D/I), xeroderma pigmentosum complementation Group D - rs13181A>C, and xeroderma pigmentosum complementation Type G rs17655 G>C polymorphisms with polymerase chain reaction (PCR)-restriction-fragment length polymorphism or allele-specific PCR methods.
|
29893334 |
2018 |
|
Carcinoma of urinary bladder, invasive
|
|
0.010 |
GeneticVariation
|
BEFREE |
These polymorphisms were also associated with both low-grade [(rs2304277 OR<sub>GG</sub> = 3.73, 95% CI = 1.72-8.09) (rs2228001 OR<sub>AC</sub> = 2.18, 95% CI = 1.21-3.92)] and high-grade tumors [(rs2304277 OR<sub>GG</sub> = 3.45, 95% CI = 1.52-7.80) (rs2228001 OR<sub>AC</sub> = 2.81, 95% CI = 1.48-5.33)] as well as with non-muscle-invasive bladder cancer [(rs2304277 OR<sub>GG</sub> = 4.03, 95% CI = 1.87-8.67) (rs2228001 OR<sub>AC</sub> = 2.14, 95% CI = 1.20-3.81)] and muscle-invasive bladder cancer [(rs2304277 OR<sub>GG</sub> = 3.06, 95%CI = 1.31-7.13) (rs2228001 OR<sub>AC</sub> = 2.95, 95%CI = 1.51-5.75)].
|
29139108 |
2018 |
|
progesterone receptor-negative breast cancer
|
|
0.010 |
GeneticVariation
|
BEFREE |
Two polymorphisms (rs2228001 and rs50872) were associated with the risk of breast cancer with negative lymph node involvement. rs1800975 and rs50872 were associated with the risk of ER- and PR- breast cancer, whereas rs11615 was associated with the risk of ER+ and PR+ breast cancer.
|
27768589 |
2016 |
|
progesterone receptor-positive breast cancer
|
|
0.010 |
GeneticVariation
|
BEFREE |
Two polymorphisms (rs2228001 and rs50872) were associated with the risk of breast cancer with negative lymph node involvement. rs1800975 and rs50872 were associated with the risk of ER- and PR- breast cancer, whereas rs11615 was associated with the risk of ER+ and PR+ breast cancer.
|
27768589 |
2016 |
|
leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this study we aimed to evaluate the associations between XPC Lys939Gln (rs2228001), XPD Lys751Gln (rs13181) and XPG Asp1104His (rs17655) polymorphisms and leukemia risk in a Tunisian population.
|
25311495 |
2015 |
|
Childhood Leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this study we aimed to evaluate the associations between XPC Lys939Gln (rs2228001), XPD Lys751Gln (rs13181) and XPG Asp1104His (rs17655) polymorphisms and leukemia risk in a Tunisian population.
|
25311495 |
2015 |
|
Carcinogenesis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Polymorphisms in Lys939Gln XPC gene may diminish DNA repair capacity, eventually increasing the risk of carcinogenesis.
|
26604426 |
2015 |
|
Squamous cell carcinoma of the head and neck
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aims of this study were to analyze the polymorphisms XRCC1 Arg194Trp, XRCC1 Arg399Gln, XRCC3 Thr241Met, XPC Lys939Gln, ERCC1 Asn118Asn, and RAD51 -98G>C and to verify their influence on radiotherapy response and prognosis of patients with head and neck squamous cell carcinoma (HNSCC).
|
26505394 |
2015 |
|
Malignant Head and Neck Neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
This meta-analysis shows that the XPC PAT and Ala499Val polymorphisms may be associated with an increased risk of HNC, while XPC Lys939Gln may not be associated with HNC risk.
|
24338715 |
2014 |
|
Head and Neck Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
This meta-analysis shows that the XPC PAT and Ala499Val polymorphisms may be associated with an increased risk of HNC, while XPC Lys939Gln may not be associated with HNC risk.
|
24338715 |
2014 |
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this study, we investigated whether six polymorphisms (including rs25487, rs861539, rs7003908, rs28383151, rs13181, and rs2228001) in DNA repair genes (XPC, XRCC4, XRCC1, XRCC4, XPD, XRCC7, and XRCC3) interacted with AFB1, and the gene-environmental interactive role in the risk of HCC using hospital-based case-control study (including 1486 HCC cases and 1996 controls).
|
25337275 |
2014 |
|
Cutaneous Melanoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Subgroup analysis in Caucasians showed that there was an obvious association between XPC Lys939Gln</span> polymorphism and cutaneous melanoma risk in Caucasians (GlnGln vs. LysLys/LysGln: OR = 1.12, 95 % CI = 1.00-1.25, P = 0.05).
|
24277375 |
2014 |
|
melanoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Subgroup analysis in Caucasians showed that there was an obvious association between XPC Lys939Gln</span> polymorphism and cutaneous melanoma risk in Caucasians (GlnGln vs. LysLys/LysGln: OR = 1.12, 95 % CI = 1.00-1.25, P = 0.05).
|
24277375 |
2014 |
|
Epithelial ovarian cancer
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results indicated that the XPC Lys939Gln polymorphism may correlate with clinical outcome of patients with epithelial ovarian cancer when treated with platinum-based chemotherapy in Northern China.
|
23621265 |
2013 |
|
Differentiated Thyroid Gland Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results suggest that NER polymorphisms such as rs2230641 (CCNH) and, possibly, rs2227869 (ERCC5) and rs2228001 (XPC), may influence DTC susceptibility.
|
23982724 |
2013 |
|
Carcinoma, Ovarian Epithelial
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results indicated that the XPC Lys939Gln polymorphism may correlate with clinical outcome of patients with epithelial ovarian cancer when treated with platinum-based chemotherapy in Northern China.
|
23621265 |
2013 |
|
Malignant neoplasm of skin
|
|
0.010 |
GeneticVariation
|
BEFREE |
Two polymorphisms in XPC, 939A>C (rs2228001) and 499C>T (rs2228000), are considered to have possible associations with the risk of skin cancer, but the reported results have been inconsistent.
|
23244095 |
2012 |
|
Gallbladder adenocarcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Ala499Val (C>T) and Lys939Gln (A>C) polymorphisms of the XPC gene: their correlation with the risk of primary gallbladder adenocarcinoma--a case-control study in China.
|
21113018 |
2011 |
|
Malignant neoplasm of gallbladder
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this study, we detected two non-synonymous polymorphisms in XPC (Ala499Val and Lys939Gln) in 334 cases of GBC and 329 subjects of hospital-based age- and sex frequency-matched controls in China using a polymerase chain reaction-restriction fragment length polymorphism assay.
|
21113018 |
2011 |
|
Gallbladder Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this study, we detected two non-synonymous polymorphisms in XPC (Ala499Val and Lys939Gln) in 334 cases of GBC and 329 subjects of hospital-based age- and sex frequency-matched controls in China using a polymerase chain reaction-restriction fragment length polymorphism assay.
|
21113018 |
2011 |
|
Stage 0 Gallbladder Cancer AJCC v8
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this study, we detected two non-synonymous polymorphisms in XPC (Ala499Val and Lys939Gln) in 334 cases of GBC and 329 subjects of hospital-based age- and sex frequency-matched controls in China using a polymerase chain reaction-restriction fragment length polymorphism assay.
|
21113018 |
2011 |
|
Stage IIB Gallbladder Cancer AJCC v8
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this study, we detected two non-synonymous polymorphisms in XPC (Ala499Val and Lys939Gln) in 334 cases of GBC and 329 subjects of hospital-based age- and sex frequency-matched controls in China using a polymerase chain reaction-restriction fragment length polymorphism assay.
|
21113018 |
2011 |