|
XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP C
|
|
0.100 |
GeneticVariation
|
BEFREE |
A meta-analysis was performed to examine the association between XPC Lys939Gln polymorphism and susceptibility to bladder cancer (BC).
|
23269608 |
2013 |
|
Carcinoma of bladder
|
|
0.100 |
GeneticVariation
|
BEFREE |
A meta-analysis was performed to examine the association between XPC Lys939Gln polymorphism and susceptibility to bladder cancer (BC).
|
23269608 |
2013 |
|
Malignant neoplasm of urinary bladder
|
|
0.100 |
GeneticVariation
|
BEFREE |
A meta-analysis was performed to examine the association between XPC Lys939Gln polymorphism and susceptibility to bladder cancer (BC).
|
23269608 |
2013 |
|
Bladder Neoplasm
|
|
0.090 |
GeneticVariation
|
BEFREE |
A meta-analysis was performed to examine the association between XPC Lys939Gln polymorphism and susceptibility to bladder cancer (BC).
|
23269608 |
2013 |
|
Bladder Neoplasm
|
|
0.090 |
GeneticVariation
|
BEFREE |
A significant association between Ala499Val polymorphism and bladder cancer was observed (OR = 1.78, CI = 1.19-2.66, p = 0.005); however, Lys939Gln was unrelated (OR = 0.97, CI = 0.65-1.45, P = 0.89).
|
27246180 |
2016 |
|
XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP C
|
|
0.100 |
GeneticVariation
|
BEFREE |
A total of 7 XPC tagging SNPs (tag-SNPs) were selected from the International HapMap Project Databases (rs2228001A/C, rs2470353G/C, rs2228000C/T, rs3731114C/G, rs3729587G/C, rs2607775C/G and rs3731055G/A) and were genotyped in 205 patients with PC and 230 non-cancer control subjects using a SNaPshot assay.
|
30344718 |
2018 |
|
Gallbladder adenocarcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Ala499Val (C>T) and Lys939Gln (A>C) polymorphisms of the XPC gene: their correlation with the risk of primary gallbladder adenocarcinoma--a case-control study in China.
|
21113018 |
2011 |
|
Prostate carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Analyses of the XPC Lys939Gln polymorphism did not show an association with PCa risk.
|
22682619 |
2012 |
|
Malignant neoplasm of prostate
|
|
0.050 |
GeneticVariation
|
BEFREE |
Analyses of the XPC Lys939Gln polymorphism did not show an association with PCa risk.
|
22682619 |
2012 |
|
Colorectal Carcinoma
|
|
0.090 |
GeneticVariation
|
BEFREE |
For Lys939Gln, the CC genotype was associated with a significantly increased risk of CRC (odds ratio (OR)=1.5; 95% confidence interval (CI)=1.0-2.2) compared with the AA genotype.
|
21104992 |
2011 |
|
Cervix carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Haplotypes A+ and C- (A > C of Lys939Gln, --> + of PAT) were significantly associated with higher susceptibility to cervical cancer (OR = 2.01, p = 0.005 and OR = 1.76, p = 0.002, respectively).
|
20377134 |
2010 |
|
cervical cancer
|
|
0.010 |
GeneticVariation
|
BEFREE |
Haplotypes A+ and C- (A > C of Lys939Gln, --> + of PAT) were significantly associated with higher susceptibility to cervical cancer (OR = 2.01, p = 0.005 and OR = 1.76, p = 0.002, respectively).
|
20377134 |
2010 |
|
Malignant tumor of cervix
|
|
0.010 |
GeneticVariation
|
BEFREE |
Haplotypes A+ and C- (A > C of Lys939Gln, --> + of PAT) were significantly associated with higher susceptibility to cervical cancer (OR = 2.01, p = 0.005 and OR = 1.76, p = 0.002, respectively).
|
20377134 |
2010 |
|
Uterine Fibroids
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, no significant association was observed for leiomyoma risk for rs2228001 A > C. This study indicated that genetic variations in XPC gene are associated with leiomyoma susceptibility in a reproductive women population.
|
31428994 |
2019 |
|
Fibroid Tumor
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, no significant association was observed for leiomyoma risk for rs2228001 A > C. This study indicated that genetic variations in XPC gene are associated with leiomyoma susceptibility in a reproductive women population.
|
31428994 |
2019 |
|
Colorectal Carcinoma
|
|
0.090 |
GeneticVariation
|
BEFREE |
In conclusion, the current data suggested that XPC Lys939Gln and XPG Asp1104His polymorphisms might contribute to the identification of patients with increased risk for CRC.
|
22213216 |
2012 |
|
XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP C
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the second part we selected 2 common single nucleotide polymorphisms within genes involved in NER (Xeroderma pigmentosum group C (XPC) Lys939Gln, Xeroderma pigmentosum group D (XPD) Lys751Gln) to determine the relation between them and CRC risk.
|
29793654 |
2018 |
|
Colorectal Carcinoma
|
|
0.090 |
GeneticVariation
|
BEFREE |
In the second part we selected 2 common single nucleotide polymorphisms within genes involved in NER (Xeroderma pigmentosum group C (XPC) Lys939Gln, Xeroderma pigmentosum group D (XPD) Lys751Gln) to determine the relation between them and CRC risk.
|
29793654 |
2018 |
|
Xeroderma pigmentosum, group G
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this case-control study of 144 OPL patients and 288 controls, we genotyped 11 polymorphisms in 8 major NER genes, including XPA [A23G at 5' untranslated region (UTR)], XPD (Asp312Asn, Lys751Gln), XPC (Ala499Val, Lys939Gln), XPG (His1104Asp), XPF (Pro662Ser), ERCC6 (Met1097Val, Arg1230Pro) Rad23B (Ala249Val), and CCNH (Val270Ala).
|
17575242 |
2007 |
|
Xeroderma pigmentosum, group F
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this case-control study of 144 OPL patients and 288 controls, we genotyped 11 polymorphisms in 8 major NER genes, including XPA [A23G at 5' untranslated region (UTR)], XPD (Asp312Asn, Lys751Gln), XPC (Ala499Val, Lys939Gln), XPG (His1104Asp), XPF (Pro662Ser), ERCC6 (Met1097Val, Arg1230Pro) Rad23B (Ala249Val), and CCNH (Val270Ala).
|
17575242 |
2007 |
|
leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this study we aimed to evaluate the associations between XPC Lys939Gln (rs2228001), XPD Lys751Gln (rs13181) and XPG Asp1104His (rs17655) polymorphisms and leukemia risk in a Tunisian population.
|
25311495 |
2015 |
|
Childhood Leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this study we aimed to evaluate the associations between XPC Lys939Gln (rs2228001), XPD Lys751Gln (rs13181) and XPG Asp1104His (rs17655) polymorphisms and leukemia risk in a Tunisian population.
|
25311495 |
2015 |
|
Malignant neoplasm of gallbladder
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this study, we detected two non-synonymous polymorphisms in XPC (Ala499Val and Lys939Gln) in 334 cases of GBC and 329 subjects of hospital-based age- and sex frequency-matched controls in China using a polymerase chain reaction-restriction fragment length polymorphism assay.
|
21113018 |
2011 |
|
Gallbladder Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this study, we detected two non-synonymous polymorphisms in XPC (Ala499Val and Lys939Gln) in 334 cases of GBC and 329 subjects of hospital-based age- and sex frequency-matched controls in China using a polymerase chain reaction-restriction fragment length polymorphism assay.
|
21113018 |
2011 |
|
Stage 0 Gallbladder Cancer AJCC v8
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this study, we detected two non-synonymous polymorphisms in XPC (Ala499Val and Lys939Gln) in 334 cases of GBC and 329 subjects of hospital-based age- and sex frequency-matched controls in China using a polymerase chain reaction-restriction fragment length polymorphism assay.
|
21113018 |
2011 |