|
Malignant neoplasm of breast
|
|
0.020 |
GeneticVariation
|
BEFREE |
<i>DNMT1</i> rs2228611 may represent a determinant of radiation-induced fibrosis in breast cancer patients with promise for clinical usefulness in genetic-based predictive models.
|
27554481 |
2017 |
|
Breast Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
<i>DNMT1</i> rs2228611 may represent a determinant of radiation-induced fibrosis in breast cancer patients with promise for clinical usefulness in genetic-based predictive models.
|
27554481 |
2017 |
|
Breast Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The meta-analysis also suggested that <i>DNMT1</i> rs16999593 (T/C) may be associated with gastric cancer, while rs2228611 (G/A) may be associated with breast cancer.
|
28473984 |
2017 |
|
Malignant neoplasm of breast
|
|
0.020 |
GeneticVariation
|
BEFREE |
The meta-analysis also suggested that <i>DNMT1</i> rs16999593 (T/C) may be associated with gastric cancer, while rs2228611 (G/A) may be associated with breast cancer.
|
28473984 |
2017 |
|
Generalized osteoarthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The CC genotypes of rs2228611 and rs2228612 of DNMT1 were associated with a lower risk for primary knee OA under a co-dominant and a recessive model [OR (95% CI) 0.4 (0.2-0.8)/0.5 (0.3-0.8) and 0.3 (0.1-0.8)/0.3 (0.1-0.7), respectively].
|
31713648 |
2020 |
|
Idiopathic osteoarthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The CC genotypes of rs2228611 and rs2228612 of DNMT1 were associated with a lower risk for primary knee OA under a co-dominant and a recessive model [OR (95% CI) 0.4 (0.2-0.8)/0.5 (0.3-0.8) and 0.3 (0.1-0.8)/0.3 (0.1-0.7), respectively].
|
31713648 |
2020 |
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
These findings indicated that rs2228611 might contribute to male hypertension via BMI-dependent mechanisms in obesity male and BMI-independent mechanisms in normal weight male.
|
29400588 |
2018 |
|
Essential Hypertension
|
|
0.010 |
GeneticVariation
|
BEFREE |
Intriguingly, rs2228611 was also a risk factor of essential hypertension in normal weight male.
|
29400588 |
2018 |
|
Obesity
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition, the mutation rate of rs222</span>8611 was higher in the obesity group compared with the normal weight group of male.
|
29400588 |
2018 |
|
Transposition of Great Vessels
|
|
0.010 |
GeneticVariation
|
BEFREE |
We genotyped 5 SNPs (rs16999593, rs16999358, and rs2228611 in DNMT1; and rs2276599 and rs2276598 in DNMT3A) in 206 patients with complete TGA and 252 healthy children.
|
28323001 |
2017 |
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
Previous studies have examined the associations of DNA methyltransferase 1 (<i>DNMT1</i>) polymorphisms, including single nucleotide polymorphisms rs16999593 (T/C), rs2228611 (G/A), and rs2228612 (A/G), with cancer risk.However, the results are inconclusive.
|
28473984 |
2017 |
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
Previous studies have examined the associations of DNA methyltransferase 1 (<i>DNMT1</i>) polymorphisms, including single nucleotide polymorphisms rs16999593 (T/C), rs2228611 (G/A), and rs2228612 (A/G), with cancer risk.However, the results are inconclusive.
|
28473984 |
2017 |
|
early pregnancy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Considering the growing evidence on the important roles of DNA methylation in gametogenesis and early pregnancy, we investigated the potential association of DNA methyltransferase gene polymorphisms (DNMT1 rs2228611, DNMT3A rs1550117, DNMT3B rs1569686) with RSA in Slovenian reproductive couples.
|
28940947 |
2017 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this study, we investigated the association of five SNPs from DNMT1 (rs8101626 and rs2228611), DNMT3A (rs34048824 and rs1550117), and DNMT3B (rs1569686) with the risk of clear cell renal cell carcinoma (ccRCC).
|
27292127 |
2016 |
|
Graves Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Rs2424913 (DNMT3B) and rs2228611 (DNMT1) were associated with susceptibility to AITD and GD in the dominant and overdominant model, respectively (rs2424913: P=0.009 for AITD, P=0.0041 for GD; rs2228611: P=0.035 for AITD, P=0.043 for GD).
|
27237591 |
2016 |
|
Oligospermia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The frequencies of rs16999593 allele A (83.6% versus 77.6%, P=0.033) and genotype AA (69.2% versus 59.0%, P=0.037) and SNP rs2228611 genotype AA (18.4% versus 9.9%, P=0.016) in patients with oligospermia were significantly higher than those in control group.
|
24631383 |
2014 |
|
Schizophrenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
DNMT1 rs2114724 (genotype P = .004, allele P = 0.022) and rs2228611 (genotype P = 0.004, allele P = 0.022) were found to be significantly associated at genotypic and allelic level with Schizophrenia in South Indian population.
|
24859147 |
2014 |
|
Azoospermia
|
|
0.010 |
GeneticVariation
|
BEFREE |
To explore the relationship between DNMT1 and spermatogenesis impairment, polymorphic distributions of single-nucleotide polymorphisms (SNP) rs16999593, rs2228612 and rs2228611 in DNMT1 were investigated in 342 infertile patients with idiopathic azoospermia or oligospermia and 232 fertile controls in a Chinese population.
|
24631383 |
2014 |
|
Carcinoma, Ovarian Epithelial
|
|
0.010 |
GeneticVariation
|
BEFREE |
The lowest p values of the trend test were observed for the DNMT1 rs2228611 and rs759920 SNPs in patients with ovarian cancer (p trend=0.0118 and p trend=0.0173, respectively).
|
23666104 |
2013 |
|
ovarian neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
The lowest p values of the trend test were observed for the DNMT1 rs2228611 and rs759920 SNPs in patients with ovarian cancer (p trend=0.0118 and p trend=0.0173, respectively).
|
23666104 |
2013 |
|
Malignant neoplasm of ovary
|
|
0.010 |
GeneticVariation
|
BEFREE |
The lowest p values of the trend test were observed for the DNMT1 rs2228611 and rs759920 SNPs in patients with ovarian cancer (p trend=0.0118 and p trend=0.0173, respectively).
|
23666104 |
2013 |