|
Rheumatoid Arthritis
|
|
0.080 |
GeneticVariation
|
BEFREE |
We observed a significant association between rs2230926 and an increased risk of SLE and RA in the Japanese population (for SLE, odds ratio [OR] 1.92, 95% confidence interval [95% CI] 1.53-2.41, P = 1.9 x 10(-8); for RA, OR 1.35, 95% CI 1.18-1.56, P = 2.6 x 10(-5)).
|
20112363 |
2010 |
|
Adult Lymphoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
However, the rs2230926 variant allele seems to confer a higher risk to develop lymphoma in pSS patients, while in RA patients, the presence of RF resulted significantly associated with the variant allele.
|
31534975 |
2019 |
|
Lymphoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
However, the rs2230926 variant allele seems to confer a higher risk to develop lymphoma in pSS patients, while in RA patients, the presence of RF resulted significantly associated with the variant allele.
|
31534975 |
2019 |
|
Childhood Lymphoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
However, the rs2230926 variant allele seems to confer a higher risk to develop lymphoma in pSS patients, while in RA patients, the presence of RF resulted significantly associated with the variant allele.
|
31534975 |
2019 |
|
Childhood Lymphoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Increased prevalence of the rs2230926 mutant variant was detected in both SS-lymphoma and SS-nonlymphoma subgroups compared to HC (8.8% vs. 7.6% vs. 3.6%, <i>p</i> values: 0.04 and 0.03, respectively) in association with higher IgM, LDH serum levels, and PB <i>Bcl-XL</i> transcripts but lower leucocyte and neutrophil counts.
|
30662920 |
2018 |
|
Adult Lymphoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Increased prevalence of the rs2230926 mutant variant was detected in both SS-lymphoma and SS-nonlymphoma subgroups compared to HC (8.8% vs. 7.6% vs. 3.6%, <i>p</i> values: 0.04 and 0.03, respectively) in association with higher IgM, LDH serum levels, and PB <i>Bcl-XL</i> transcripts but lower leucocyte and neutrophil counts.
|
30662920 |
2018 |
|
Lymphoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Increased prevalence of the rs2230926 mutant variant was detected in both SS-lymphoma and SS-nonlymphoma subgroups compared to HC (8.8% vs. 7.6% vs. 3.6%, <i>p</i> values: 0.04 and 0.03, respectively) in association with higher IgM, LDH serum levels, and PB <i>Bcl-XL</i> transcripts but lower leucocyte and neutrophil counts.
|
30662920 |
2018 |
|
Childhood Lymphoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
A germline and coding polymorphism (rs2230926) of TNFAIP3 (A20), a central gatekeeper of nuclear factor-kappa B (NF-kB) activation, was recently found associated with primary Sjögren's syndrome (pSS)-associated lymphoma in a French cohort.We aimed to replicate this association.
|
26338037 |
2016 |
|
Adult Lymphoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
A germline and coding polymorphism (rs2230926) of TNFAIP3 (A20), a central gatekeeper of nuclear factor-kappa B (NF-kB) activation, was recently found associated with primary Sjögren's syndrome (pSS)-associated lymphoma in a French cohort.We aimed to replicate this association.
|
26338037 |
2016 |
|
Lymphoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
A germline and coding polymorphism (rs2230926) of TNFAIP3 (A20), a central gatekeeper of nuclear factor-kappa B (NF-kB) activation, was recently found associated with primary Sjögren's syndrome (pSS)-associated lymphoma in a French cohort.We aimed to replicate this association.
|
26338037 |
2016 |
|
Lymphoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
The rs2230926 exonic variant was associated with an increased risk for pSS complicated by lymphoma (odds ratio, 3.36 [95% confidence interval, 1.34-8.42], and odds ratio, 3.26 [95% confidence interval, 1.31-8.12], vs controls and pSS patients without lymphoma, respectively; P = .011).
|
24159176 |
2013 |
|
Adult Lymphoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
The rs2230926 exonic variant was associated with an increased risk for pSS complicated by lymphoma (odds ratio, 3.36 [95% confidence interval, 1.34-8.42], and odds ratio, 3.26 [95% confidence interval, 1.31-8.12], vs controls and pSS patients without lymphoma, respectively; P = .011).
|
24159176 |
2013 |
|
Childhood Lymphoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
The rs2230926 exonic variant was associated with an increased risk for pSS complicated by lymphoma (odds ratio, 3.36 [95% confidence interval, 1.34-8.42], and odds ratio, 3.26 [95% confidence interval, 1.31-8.12], vs controls and pSS patients without lymphoma, respectively; P = .011).
|
24159176 |
2013 |
|
Primary Sjögren's syndrome
|
|
0.030 |
GeneticVariation
|
BEFREE |
TNFAIP3 F127C Coding Variation in Greek Primary Sjogren's Syndrome Patients.
|
30662920 |
2018 |
|
Primary Sjögren's syndrome
|
|
0.030 |
GeneticVariation
|
BEFREE |
In both cohorts, the rs2230926 missense polymorphism was not associated with pSS.
|
26338037 |
2016 |
|
Primary Sjögren's syndrome
|
|
0.030 |
GeneticVariation
|
BEFREE |
The rs2230926 exonic variant was associated with an increased risk for pSS complicated by lymphoma (odds ratio, 3.36 [95% confidence interval, 1.34-8.42], and odds ratio, 3.26 [95% confidence interval, 1.31-8.12], vs controls and pSS patients without lymphoma, respectively; P = .011).
|
24159176 |
2013 |
|
Sjogren's Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
Increased prevalence of the rs2230926 mutant variant was detected in both SS-lymphoma and SS-nonlymphoma subgroups compared to HC (8.8% vs. 7.6% vs. 3.6%, <i>p</i> values: 0.04 and 0.03, respectively) in association with higher IgM, LDH serum levels, and PB <i>Bcl-XL</i> transcripts but lower leucocyte and neutrophil counts.
|
30662920 |
2018 |
|
Psoriasis
|
|
0.020 |
GeneticVariation
|
BEFREE |
In this study, we report association of response of psoriasis to TNF blockers with two TNFAIP3 single-nucleotide polymorphisms (rs2230926 in exon 7 and rs610604 in intron 3) and their haplotypes.
|
22113471 |
2012 |
|
Sjogren's Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
Genotyping of the most common coding polymorphism, rs2230926, in the MADGC collection and additional control individuals revealed a significant association with Sjögren's syndrome (OR=3.38, P=0.038), Crohn's disease (OR=2.25, P=0.041), psoriasis (OR=0.037, P=0.036) and RA (OR=1.9, P=0.025).
|
21326317 |
2011 |
|
Psoriasis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Genotyping of the most common coding polymorphism, rs2230926, in the MADGC collection and additional control individuals revealed a significant association with Sjögren's syndrome (OR=3.38, P=0.038), Crohn's disease (OR=2.25, P=0.041), psoriasis (OR=0.037, P=0.036) and RA (OR=1.9, P=0.025).
|
21326317 |
2011 |
|
Lymphoma, Large-Cell, Follicular
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs2230926 gene variant was genotyped in 327 primary Greek SS patients (ninety-one complicated by NHL (SS-lymphoma)) and 448 Greek healthy controls (HC) of similar age and sex distribution.
|
30662920 |
2018 |
|
Lymphoma, Non-Hodgkin
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs2230926 gene variant was genotyped in 327 primary Greek SS patients (ninety-one complicated by NHL (SS-lymphoma)) and 448 Greek healthy controls (HC) of similar age and sex distribution.
|
30662920 |
2018 |
|
B-Cell Lymphomas
|
|
0.010 |
GeneticVariation
|
BEFREE |
A coding <i>TNFAIP3</i> variant, namely rs2230926, has been previously linked to B cell non-Hodgkin's lymphoma (NHL) development in patients with Sjogren's syndrome (SS) of French and UK origin.
|
30662920 |
2018 |
|
Lymphoma, Non-Hodgkin, Familial
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs2230926 gene variant was genotyped in 327 primary Greek SS patients (ninety-one complicated by NHL (SS-lymphoma)) and 448 Greek healthy controls (HC) of similar age and sex distribution.
|
30662920 |
2018 |
|
Rheumatism
|
|
0.010 |
GeneticVariation
|
BEFREE |
TNFAIP3 (rs2230926) had the strongest effect related to European League Against Rheumatism response.
|
28639493 |
2017 |