|
Rheumatoid Arthritis
|
|
0.080 |
GeneticVariation
|
BEFREE |
Rs10499194 and rs2230926 polymorphisms in the TNFAIP3 gene region may be susceptibility factors for rheumatoid arthritis in the northern Chinese Han population.
|
24884566 |
2014 |
|
Adult type dermatomyositis
|
|
0.010 |
GeneticVariation
|
BEFREE |
And rs2230926 and rs5029939 were significantly associated with interstitial lung disease (ILD) in PM/DM and PM patients (P(c) = 0.04 and P(c) = 0.016; P(c) = 0.02 and P(c) = 0.03, respectively).
|
25337792 |
2014 |
|
Lung Diseases, Interstitial
|
|
0.010 |
GeneticVariation
|
BEFREE |
And rs2230926 and rs5029939 were significantly associated with interstitial lung disease (ILD) in PM/DM and PM patients (P(c) = 0.04 and P(c) = 0.016; P(c) = 0.02 and P(c) = 0.03, respectively).
|
25337792 |
2014 |
|
Polymyositis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our study indicated a strong allele association was observed in PM/DM and PM patients for rs2230926</span> (OR: 1.61, 95%CI: 1.20-2.16, P(c) = 7.5×10(-3); OR: 1.88, 95%CI: 1.30-2.74, P(c) = 4.0×10(-3), respectively) and rs5029939 (OR: 1.64, 95%CI: 1.21-2.21, P(c) = 6.0×10(-3); OR: 1.88, 95%CI: 1.28-2.76, P(c) = 5.5×10(-3), respectively).
|
25337792 |
2014 |
|
Dermatomyositis
|
|
0.010 |
GeneticVariation
|
BEFREE |
And rs2230926 and rs5029939 were significantly associated with interstitial lung disease (ILD) in PM/DM and PM patients (P(c) = 0.04 and P(c) = 0.016; P(c) = 0.02 and P(c) = 0.03, respectively).
|
25337792 |
2014 |
|
Rheumatoid Arthritis
|
|
0.080 |
GeneticVariation
|
BEFREE |
In the present study, our results indicated that the genetic polymorphism of rs2230926 in TNFAIP3 may be a susceptible factor conferring risk for RA in southern Chinese Han population.
|
25674272 |
2014 |
|
Immune thrombocytopenic purpura
|
|
0.010 |
GeneticVariation
|
BEFREE |
We observed significant difference in the allelic and genotypic distributions of rs2230926 and rs5029939 between the ITP and control groups (p < 0.05).
|
25806576 |
2016 |
|
Hepatitis, Chronic
|
|
0.010 |
GeneticVariation
|
BEFREE |
The genotype and allele frequencies of TNFAIP3 rs2230926 polymorphism between HBV patients with chronic hepatitis, liver cirrhosis and hepatocellular carcinoma also showed no significant difference.
|
25890346 |
2015 |
|
Hepatitis B
|
|
0.010 |
GeneticVariation
|
BEFREE |
The TNFAIP3 rs2230926 polymorphism is not suggested to be associated with the susceptibility of chronic HBV infection or the progression of HBV-related diseases in this study.
|
25890346 |
2015 |
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The genotype and allele frequencies of TNFAIP3 rs2230926 polymorphism between HBV patients with chronic hepatitis, liver cirrhosis and hepatocellular carcinoma also showed no significant difference.
|
25890346 |
2015 |
|
Hepatitis B, Chronic
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association between TNFAIP3 nonsynonymous single-nucleotide polymorphism rs2230926 and chronic hepatitis B virus infection in a Chinese Han population.
|
25890346 |
2015 |
|
Rheumatoid Arthritis
|
|
0.080 |
GeneticVariation
|
BEFREE |
A20 rs2230926 TG genotype and rs146534657 AG genotype may be related to poor outcome in RA patients.
|
26143186 |
2015 |
|
Childhood Lymphoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
A germline and coding polymorphism (rs2230926) of TNFAIP3 (A20), a central gatekeeper of nuclear factor-kappa B (NF-kB) activation, was recently found associated with primary Sjögren's syndrome (pSS)-associated lymphoma in a French cohort.We aimed to replicate this association.
|
26338037 |
2016 |
|
Adult Lymphoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
A germline and coding polymorphism (rs2230926) of TNFAIP3 (A20), a central gatekeeper of nuclear factor-kappa B (NF-kB) activation, was recently found associated with primary Sjögren's syndrome (pSS)-associated lymphoma in a French cohort.We aimed to replicate this association.
|
26338037 |
2016 |
|
Lymphoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
A germline and coding polymorphism (rs2230926) of TNFAIP3 (A20), a central gatekeeper of nuclear factor-kappa B (NF-kB) activation, was recently found associated with primary Sjögren's syndrome (pSS)-associated lymphoma in a French cohort.We aimed to replicate this association.
|
26338037 |
2016 |
|
Primary Sjögren's syndrome
|
|
0.030 |
GeneticVariation
|
BEFREE |
In both cohorts, the rs2230926 missense polymorphism was not associated with pSS.
|
26338037 |
2016 |
|
Lupus Erythematosus, Systemic
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Identification of a Systemic Lupus Erythematosus Risk Locus Spanning ATG16L2, FCHSD2, and P2RY2 in Koreans.
|
26663301 |
2016 |
|
Lupus Erythematosus, Systemic
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus.
|
27399966 |
2016 |
|
Lupus Erythematosus, Systemic
|
|
0.900 |
GeneticVariation
|
BEFREE |
The results of our meta-analysis suggest that TNFAIP3 (rs2230926, rs5029937, rs5029939, and rs3757173) polymorphisms are associated with susceptibility to SLE.
|
27726311 |
2016 |
|
Rheumatoid Arthritis
|
|
0.080 |
GeneticVariation
|
BEFREE |
Meta-analysis indicated that TNFAIP3 gene rs6920220, rs2230926, and rs5029937 polymorphisms were associated with the increased risk of RA.
|
28199970 |
2017 |
|
Systemic Scleroderma
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Transethnic meta-analysis identifies GSDMA and PRDM1 as susceptibility genes to systemic sclerosis.
|
28314753 |
2017 |
|
Rheumatism
|
|
0.010 |
GeneticVariation
|
BEFREE |
TNFAIP3 (rs2230926) had the strongest effect related to European League Against Rheumatism response.
|
28639493 |
2017 |
|
Collagen Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
TNFAIP3 (rs2230926) had the strongest effect related to European League Against Rheumatism response.
|
28639493 |
2017 |
|
Rheumatoid Arthritis
|
|
0.080 |
GeneticVariation
|
BEFREE |
In conclusion, this meta-analysis demonstrates that TNFAIP3 gene polymorphisms (rs2230926 and rs5029937) are associated with the increased risk of RA.
|
28888761 |
2017 |
|
Lupus Erythematosus, Systemic
|
|
0.900 |
GeneticVariation
|
BEFREE |
The TT > A variants and the TNFAIP3 exon 3 coding variant rs2230926 demonstrated significant associations in SLE (P<sub>TT > A</sub> = 8.96 × 10<sup>-12</sup>, odds ratio [OR] = 2.07, 95% confidence interval [CI] = 1.68-2.55).
|
30529365 |
2019 |