|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.880 |
GeneticVariation
|
GWASCAT |
Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population.
|
30718926 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.880 |
GeneticVariation
|
BEFREE |
In the first stage, SNPs rs1552224 at CENTD2 were significantly associated with T2D and the association was statistically significant in the whole study population (P = 0.001) although it was not replicated in the second stage. rs1552224 and rs2237897 of KCNQ1 showed significant joint effect on T2D and there was a significant decreased risk of T2D with the number increase of risk alleles (P for trend = 3.81 × 10(-17)).
|
25749274 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.880 |
GeneticVariation
|
GWASCAT |
Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico.
|
24390345 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.880 |
GeneticVariation
|
GWASDB |
Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico.
|
24390345 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.880 |
GeneticVariation
|
BEFREE |
We aimed to evaluate the effect of four common variants (rs2237892, rs2283228, rs2237895, and rs2237897) in KCNQ1 on susceptibility of type 2 diabetes (T2D) by performing a case-control study as well as a comprehensive meta-analysis.
|
23786590 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.880 |
GeneticVariation
|
BEFREE |
Seven of the 29 single nucleotide polymorphisms (SNPs) examined were found to be associated with T2D risk at P ≤ 0.05, including rs6769511 (IGF2BP2), 2 SNPs in the WFS1 gene (rs4689388 and rs1801214), rs7903146 (TCF7L2), and 3 SNPs in the KCNQ1 gene (rs231362, rs2237892, and rs2237897).
|
23144361 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.880 |
GeneticVariation
|
BEFREE |
Four single nucleotide polymorphisms (SNPs) (rs2237892, rs2237895, rs2237897, and rs2283228) in KCNQ1 are reported to be associated with type 2 diabetes mellitus (T2DM), possibly caused by a reduction in insulin secretion and higher fasting glucose, but the results are inconsistent.
|
20701788 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.880 |
GeneticVariation
|
BEFREE |
Four single nucleotide polymorphisms (SNPs, rs2237892, rs2237895, rs2237897, rs2283228) in KCNQ1 are associated with type 2 diabetes mellitus in different ancestral groups.
|
19575309 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.880 |
GeneticVariation
|
GWASDB |
A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese.
|
20174558 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.880 |
GeneticVariation
|
BEFREE |
Combined analysis by a meta-analysis revealed that the T allele of rs2237897 was significantly associated with susceptibility to diabetic nephropathy in Japanese subjects with type 2 diabetes (odds ratio 1.22 [95% CI 1.10-1.34], P = 3.1 x 10(-4), corrected P = 0.01).
|
20056949 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.880 |
GeneticVariation
|
BEFREE |
Notably, the associations with type 2 diabetes were markedly attenuated after adjusting for HOMA-B (OR(rs2237892): 1.33 [1.05-1.68], P = 0.018; OR(rs2237895): 1.24 [1.00-1.54], P = 0.0524; OR(rs2237897): 1.22[0.98-1.53], P = 0.09).
|
19556355 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.880 |
GeneticVariation
|
GWASDB |
The association of these SNPs with type 2 diabetes was replicated in samples from Singaporean (additive model: rs2237895, P = 8.5 x 10(-3); OR = 1.14, rs2237897, P = 2.4 x 10(-4); OR = 1.22) and Danish populations (additive model: rs2237895, P = 3.7 x 10(-11); OR = 1.24, rs2237897, P = 1.2 x 10(-4); OR = 1.36).
|
18711366 |
2008 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.880 |
GeneticVariation
|
GWASCAT |
The association of these SNPs with type 2 diabetes was replicated in samples from Singaporean (additive model: rs2237895, P = 8.5 x 10(-3); OR = 1.14, rs2237897, P = 2.4 x 10(-4); OR = 1.22) and Danish populations (additive model: rs2237895, P = 3.7 x 10(-11); OR = 1.24, rs2237897, P = 1.2 x 10(-4); OR = 1.36).
|
18711366 |
2008 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.880 |
GeneticVariation
|
BEFREE |
Several other SNPs in the same linkage disequilibrium (LD) block were strongly associated with type 2 diabetes (additive model: rs2237895, P = 7.3 x 10(-9); OR = 1.32, 95% CI = 1.20-1.45, rs2237897, P = 6.8 x 10(-13); OR = 1.41, 95% CI = 1.29-1.55).
|
18711366 |
2008 |
|
Body mass index
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies 112 new loci for body mass index in the Japanese population.
|
28892062 |
2017 |
|
Coronary heart disease
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
|
21347282 |
2011 |
|
Diabetic Nephropathy
|
|
0.020 |
GeneticVariation
|
BEFREE |
A trend of increasing OR was observed with increasing severity of diabetic nephropathy (low and high microalbuminuria, macroalbuminuria). rs2237897, previously implicated in the earlier Japanese study, was also associated with macroalbuminuria, but this finding did not remain significant after correction for multiple testing.
|
22696034 |
2012 |
|
Diabetic Nephropathy
|
|
0.020 |
GeneticVariation
|
BEFREE |
Combined analysis by a meta-analysis revealed that the T allele of rs2237897 was significantly associated with susceptibility to diabetic nephropathy in Japanese subjects with type 2 diabetes (odds ratio 1.22 [95% CI 1.10-1.34], P = 3.1 x 10(-4), corrected P = 0.01).
|
20056949 |
2010 |
|
Obesity, Metabolically Benign
|
|
0.010 |
GeneticVariation
|
BEFREE |
Waist circumference was an independent predictor of MHO, regardless of definitions, whereas walking to school and KCNQ1-rs2237897 were independent predictors of MHO-CR.
|
26913634 |
2016 |
|
Kidney Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
We also found that the T allele frequencies of rs2237897 were consistently higher in the nephropathy groups than in the control groups for all study populations (initial study: 0.33 vs. 0.27; replication 1: 0.32 vs. 0.30; replication 2: 0.33 vs. 0.28; and replication 3: 0.32 vs. 0.28), although the individual associations did not reach statistically significant levels.
|
20056949 |
2010 |