|
Glioma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Nine polymorphisms in genes within the IL-4/IL-13 pathway (IL-4 rs2243250, rs2070874, rs2243248, IL-4R rs1805011, rs1805012, rs1805015, rs1801275, and IL-13 rs20541 and rs1800925) were assessed for their relationship with glioma risk by computing odds ratios (ORs) and corresponding 95 % confidence intervals (CIs).
|
25472582 |
2015 |
|
Glioma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The IL4 (rs2243248, -1098T>G) and IL6 (rs1800795, -174G>C) polymorphisms were significantly associated with risk of glioma in the pooled analysis (P trend = 0.006 and 0.04, respectively), although these became attenuated after controlling for the false discovery rate (P trend = 0.07 and 0.22, respectively).
|
17916900 |
2007 |
|
Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
Variants rs10889677, rs2201841, and rs7517847 of IL-23R, and variant rs2243248 of IL-4, showed strong associations with SAPHO syndrome.
|
31701644 |
2019 |
|
Multiple Sclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The present case-control study inspected the association between seven single nucleotide polymorphisms (SNPs) of IL4 (IL4<sub>-1098</sub>: rs2243248, IL4<sub>-590</sub>: rs2243250, and IL4<sub>-33</sub>: rs2070874), IL4RA (IL4RA<sub>+1902</sub>: rs1801275), and IL10 (IL10<sub>-1082</sub>: rs1800896, IL10<sub>-819</sub>: rs1800871, and IL10<sub>-592</sub>: rs1800872) genes and MS in Iraqi patients.
|
31264107 |
2019 |
|
Chronic Periodontitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The results suggest that the polymorphism rs2243248 and haplotypes C-G-T and C-T-T may be associated with CP s</span>usceptibility in the present Han Chinese population.
|
27195298 |
2016 |
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
The present study aimed at evaluating the contribution of IL-4 promoter T-1099G (rs2243248), C-589T (rs2243250), C-33T (rs2070874) genetic polymorphisms to the risk of lung cancer in Taiwan.
|
26504066 |
2015 |
|
Primary malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
The present study aimed at evaluating the contribution of IL-4 promoter T-1099G (rs2243248), C-589T (rs2243250), C-33T (rs2070874) genetic polymorphisms to the risk of lung cancer in Taiwan.
|
26504066 |
2015 |
|
Malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
The present study aimed at evaluating the contribution of IL-4 promoter T-1099G (rs2243248), C-589T (rs2243250), C-33T (rs2070874) genetic polymorphisms to the risk of lung cancer in Taiwan.
|
26504066 |
2015 |
|
Glioblastoma Multiforme
|
|
0.010 |
GeneticVariation
|
BEFREE |
The genotype "AG" of rs1801275 in the IL-4R gene showed an increase risk in over-dominant model (OR = 2.29; 95% CI, 1.20 - 4.35; p = 0.0081) We further analyzed whether the six cytokine genes have a different effect on the disease in gender specific population, and found that the allele "G" of rs2243248 in the IL-4 gene showed a decrease risk of GBM in female (OR = 0.35, 95% CI, 0.13 - 0.94, p = 0.0032), but the allele "T" showed a decrease risk in male (OR = 0.30, 95% CI, 0.17 - 0.53, p = 0.0032).
|
23663500 |
2013 |
|
Glioblastoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The genotype "AG" of rs1801275 in the IL-4R gene showed an increase risk in over-dominant model (OR = 2.29; 95% CI, 1.20 - 4.35; p = 0.0081) We further analyzed whether the six cytokine genes have a different effect on the disease in gender specific population, and found that the allele "G" of rs2243248 in the IL-4 gene showed a decrease risk of GBM in female (OR = 0.35, 95% CI, 0.13 - 0.94, p = 0.0032), but the allele "T" showed a decrease risk in male (OR = 0.30, 95% CI, 0.17 - 0.53, p = 0.0032).
|
23663500 |
2013 |