|
Body mass index
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Septicemia
|
|
0.020 |
GeneticVariation
|
BEFREE |
The HMGB1 gene rs2249825 and rs1045411 site SNPs are associated with susceptibility and outcomes of Chinese Han patients with sepsis.
|
30423384 |
2019 |
|
Sepsis
|
|
0.020 |
GeneticVariation
|
BEFREE |
The HMGB1 gene rs2249825 and rs1045411 site SNPs are associated with susceptibility and outcomes of Chinese Han patients with sepsis.
|
30423384 |
2019 |
|
Carcinoma of lung
|
|
0.020 |
GeneticVariation
|
BEFREE |
We found that the CT or CC+CT heterozygotes of the <i>HMGB1</i> rs1045411 polymorphism reduced the risks for lung cancer, while the G/T/C haplotypes of three <i>HMGB1</i> SNPs (rs1360485, rs1045411 and rs2249825) also reduced the risk for lung cancer by almost half (0.486-fold).
|
29104475 |
2017 |
|
Malignant neoplasm of lung
|
|
0.020 |
GeneticVariation
|
BEFREE |
We found that the CT or CC+CT heterozygotes of the <i>HMGB1</i> rs1045411 polymorphism reduced the risks for lung cancer, while the G/T/C haplotypes of three <i>HMGB1</i> SNPs (rs1360485, rs1045411 and rs2249825) also reduced the risk for lung cancer by almost half (0.486-fold).
|
29104475 |
2017 |
|
Primary malignant neoplasm of lung
|
|
0.020 |
GeneticVariation
|
BEFREE |
We found that the CT or CC+CT heterozygotes of the <i>HMGB1</i> rs1045411 polymorphism reduced the risks for lung cancer, while the G/T/C haplotypes of three <i>HMGB1</i> SNPs (rs1360485, rs1045411 and rs2249825) also reduced the risk for lung cancer by almost half (0.486-fold).
|
29104475 |
2017 |
|
Carcinoma of lung
|
|
0.020 |
GeneticVariation
|
BEFREE |
The HMGB1 SNPs (rs1412125 and rs2249825) were associated with platinum-based chemotherapy responses in Chinese lung cancer patients.
|
24684392 |
2014 |
|
Primary malignant neoplasm of lung
|
|
0.020 |
GeneticVariation
|
BEFREE |
The HMGB1 SNPs (rs1412125 and rs2249825) were associated with platinum-based chemotherapy responses in Chinese lung cancer patients.
|
24684392 |
2014 |
|
Malignant neoplasm of lung
|
|
0.020 |
GeneticVariation
|
BEFREE |
The HMGB1 SNPs (rs1412125 and rs2249825) were associated with platinum-based chemotherapy responses in Chinese lung cancer patients.
|
24684392 |
2014 |
|
Sepsis
|
|
0.020 |
GeneticVariation
|
BEFREE |
The rs2249825 and the haplotype TCG might be used as relevant risk estimate for the development of sepsis and MODS in patients with major trauma.
|
22047946 |
2012 |
|
Septicemia
|
|
0.020 |
GeneticVariation
|
BEFREE |
The rs2249825 and the haplotype TCG might be used as relevant risk estimate for the development of sepsis and MODS in patients with major trauma.
|
22047946 |
2012 |
|
Pneumonia
|
|
0.010 |
GeneticVariation
|
BEFREE |
SNPs at the rs1412125 and rs2249825 loci of HMGB1 are associated with pneumonia in terms of susceptibility, severity, and inflammatory response.
|
30562142 |
2019 |
|
Community acquired pneumonia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The genotypes of HMGB1 rs1412125 (-1615T > C), rs2249825 (3814C > G), and rs1045411 (2262C > T) loci in 328 patients with community-acquired pneumonia (CAP) and 317 healthy subjects were analyzed by Sanger sequencing.
|
30562142 |
2019 |
|
CATARACT, ANTERIOR POLAR
|
|
0.010 |
GeneticVariation
|
BEFREE |
The risk of CAP was higher in carriers of the mutant HMGB1 rs1412125 and rs2249825 alleles than those that had the wild type alleles (adjusted odds ratio [OR] = 1.241; 95% confidence interval [CI] = 1.061-1.448; p = 0.007; adjusted OR = 1.225; 95% CI = 1.038-1.427; p = 0.016, respectively).
|
30562142 |
2019 |
|
Secondary malignant neoplasm of lymph node
|
|
0.010 |
GeneticVariation
|
BEFREE |
Patients with one G allele in the rs1360485 or rs2249825 domains are likely to progress to T2 tumor and lymph node metastasis.
|
29725248 |
2018 |
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
This meta-analysis was performed assess four HMGB1 polymorphisms (rs1045411, rs2249825, rs1360485 and rs1412125) in cancer risk.
|
29730397 |
2018 |
|
Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition, the presence of one G allele in SNPs rs1360485 or rs2249825 was associated with a higher risk of progressing to T2 tumor and distant metastasis amongst HER2-enriched and triple-negative breast cancer (TNBC) tumors compared with luminal A and luminal B tumors.
|
29725248 |
2018 |
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
We report on the association between 4 SNPs of the <i>HMGB1</i> gene (rs1360485, rs1045411, rs2249825 and rs1412125) and breast cancer susceptibility as well as clinical outcomes in 313 patients with breast cancer and in 217 healthy controls.
|
29725248 |
2018 |
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We report on the association between 4 SNPs of the <i>HMGB1</i> gene (rs1360485, rs1045411, rs2249825 and rs1412125) and breast cancer susceptibility as well as clinical outcomes in 313 patients with breast cancer and in 217 healthy controls.
|
29725248 |
2018 |
|
Triple Negative Breast Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition, the presence of one G allele in SNPs rs1360485 or rs2249825 was associated with a higher risk of progressing to T2 tumor and distant metastasis amongst HER2-enriched and triple-negative breast cancer (TNBC) tumors compared with luminal A and luminal B tumors.
|
29725248 |
2018 |
|
Neoplasm Metastasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition, the presence of one G allele in SNPs rs1360485 or rs2249825 was associated with a higher risk of progressing to T2 tumor and distant metastasis amongst HER2-enriched and triple-negative breast cancer (TNBC) tumors compared with luminal A and luminal B tumors.
|
29725248 |
2018 |
|
Triple-Negative Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition, the presence of one G allele in SNPs rs1360485 or rs2249825 was associated with a higher risk of progressing to T2 tumor and distant metastasis amongst HER2-enriched and triple-negative breast cancer (TNBC) tumors compared with luminal A and luminal B tumors.
|
29725248 |
2018 |
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
This meta-analysis was performed assess four HMGB1 polymorphisms (rs1045411, rs2249825, rs1360485 and rs1412125) in cancer risk.
|
29730397 |
2018 |
|
Rheumatoid Arthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found that having one C allele in rs1360485 and one G allele in rs2249825 polymorphisms lowered the risk of RA in females.
|
29200952 |
2017 |
|
Ischemic stroke
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found that the rs2070600 variant of <i>RAGE</i> was associated with an increased risk of IS (OR = 1.19, 95% CI: 1.02-1.38, P = 0.043), whereas the rs2249825 variant of <i>HMGB1</i> was associated with a decreased risk of IS (OR = 0.83, 95% CI: 0.71-0.98, P = 0.041).
|
29245967 |
2017 |