|
Graves Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
This suggests that the Thr92Ala variant of the DIO2 gene is associated or may be in linkage disequilibrium with a functional DIO2 polymorphism which involves in the development of GD in a Russian population.
|
15542398 |
2004 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.060 |
GeneticVariation
|
BEFREE |
An association among the Thr92Ala DIO2 variant and type 2 diabetes</span>, indices of insulin resistance (HOMA-IR), insulin secretion, free thyroid hormones, and thyrotropin (TSH) was found.
|
16356084 |
2005 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.060 |
GeneticVariation
|
BEFREE |
The DIO2 Thr92Ala variant does not confer an increased risk of T2D, obesity, or insulin resistance.
|
17077128 |
2007 |
|
Metabolic Syndrome X
|
|
0.030 |
GeneticVariation
|
BEFREE |
Interaction of DIO2 T92A and PPARgamma2 P12A polymorphisms in the modulation of metabolic syndrome.
|
18198294 |
2007 |
|
Hypertensive disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
The present study evaluated whether a type 2 iodothyronine deiodinase nonsynonymous polymorphism, threonine 92 to alanine (Thr92Ala), is a determinant of hypertension susceptibility.
|
17224473 |
2007 |
|
Obesity
|
|
0.020 |
GeneticVariation
|
BEFREE |
We detected no significant association of the DIO2 Thr92Ala polymorphism with T2D or obesity.
|
17077128 |
2007 |
|
Alzheimer's Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
We investigated the association of recently identified polymorphisms in the DIO1 (D1a-C/T, D1b-A/G) and DIO2 (D2-ORFa-Gly3Asp, D2-Thr92Ala) genes with circulating thyroid parameters and early neuroimaging markers of AD.
|
17105838 |
2007 |
|
Osteoarthritis of hip
|
|
0.010 |
GeneticVariation
|
BEFREE |
Confirmation and replication by association in the additional osteoarthritis studies indicated a common DIO2 haplotype, exclusively containing the minor allele of rs225014 and common allele of rs12885300, with a combined recessive odds ratio of 1.79, 95% confidence interval (CI) 1.37-2.34 with P = 2.02 x 10(-5) in female cases with advanced/symptomatic hip osteoarthritis.
|
18334578 |
2008 |
|
Graves Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Type 2 deiodinase Thr92Ala polymorphism impact on clinical course and myocardial remodeling in patients with Graves' disease.
|
19684474 |
2009 |
|
Cardiomyopathies
|
|
0.010 |
GeneticVariation
|
BEFREE |
Recent studies showed that certain polymorphisms, including Thr92Ala of D2 gene, are implicated in the development of thyrotoxic symptoms and thyreotoxic cardiomyopathy.
|
19684474 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.060 |
GeneticVariation
|
BEFREE |
Association of the type 2 deiodinase Thr92Ala polymorphism with type 2 diabetes: case-control study and meta-analysis.
|
20566590 |
2010 |
|
Hyperinsulinism
|
|
0.010 |
GeneticVariation
|
BEFREE |
A single-nucleotide polymorphism in D2 (Thr92Ala) has been associated with increased insulin resistance in nondiabetic and type 2 diabetes (DM2) subjects.
|
20566590 |
2010 |
|
Dystrophia myotonica 2
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results indicate that in a case-control study, the homozygosity for D2 Thr92Ala polymorphism is associated with increased risk for DM2.
|
20566590 |
2010 |
|
Metabolic Syndrome X
|
|
0.030 |
GeneticVariation
|
BEFREE |
Recently, it was reported that the D2 Thr92Ala (rs225014) and the peroxisome proliferator-activated receptor (PPAR) γ2 Pro12Ala (rs1801282) polymorphisms interact in the modulation of metabolic syndrome in nondiabetic subjects.
|
20930717 |
2011 |
|
Severe Sepsis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The G (Ala) allele of the Thr92Ala coding single-nucleotide polymorphism (rs225014) was protective in severe sepsis and severe sepsis-associated ALI after adjustments for age, sex, and genetic ancestry in a logistic regression model in European Americans.
|
21685153 |
2011 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.060 |
GeneticVariation
|
BEFREE |
The Thr92Ala variant common in Pima Indians, rs225011, and rs225015 were modestly associated with early-onset T2DM (p=0.01-0.04) in the case-control study, but were not associated with obesity in the obesity case-control study, nor associated with T2DM (at any age) or body-mass index (BMI; as a quantitative trait) in the family-based analysis.
|
22142372 |
2012 |
|
Obesity
|
|
0.020 |
GeneticVariation
|
BEFREE |
The Thr92Ala variant common in Pima Indians, rs225011, and rs225015 were modestly associated with early-onset T2DM (p=0.01-0.04) in the case-control study, but were not associated with obesity in the obesity case-control study, nor associated with T2DM (at any age) or body-mass index (BMI; as a quantitative trait) in the family-based analysis.
|
22142372 |
2012 |
|
Degenerative polyarthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The allelic imbalance of the DIO2 mRNA transcript, with the OA risk allele 'C' of rs225014 more abundant than the wild-type 'T' allele in heterozygote carriers provides a possible mechanism by which genetic variation at DIO2 confers OA risk.
|
22492780 |
2012 |
|
Hypothyroidism
|
|
0.050 |
GeneticVariation
|
BEFREE |
A polymorphism (Thr92Ala) in the gene encoding the deiodinase 2 (D2) enzyme that converts thyroxine to triiodothyronine in the brain was later identified in about 16% of hypothyroid persons.
|
22548953 |
2013 |
|
Kashin-Beck Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
In this study, we showed that single SNPs in the genes GPX1 (rs1050450, rs1800668 and rs3811699), TrxR2 (rs5748469), and DIO2 (rs225014) may not be significantly associated with KBD in a Tibetan population.
|
24058403 |
2013 |
|
Autoimmune Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
Prevalence of Dio2(T92A) polymorphism and its association with thyroid autoimmunity.
|
23013882 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.060 |
GeneticVariation
|
BEFREE |
In conclusion, the rs225017 polymorphism is associated with greater IR in T2DM and it seems to interact with the Thr92Ala polymorphism in the modulation of IR.
|
25105294 |
2014 |
|
Recurrent depressive disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
The specific variant of the DIO2 gene, namely the CC genotype of the Thr92Ala polymorphism, was more frequently found in healthy subjects than in patients with depression, what suggests that it could potentially serve as a marker of a lower risk for recurrent depressive disorder.
|
26098717 |
2015 |
|
Recurrent depression
|
|
0.010 |
GeneticVariation
|
BEFREE |
The current study investigates whether a specific single nucleotide polymorphism (SNP) of the DIO2 gene, Thr92Ala (T/C); rs 225014 or ORFa-Gly3Asp (C/T); rs 12885300, correlate with the risk for recurrent depression.
|
26098717 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.060 |
GeneticVariation
|
BEFREE |
Homozygosity for the Dio2 Thr92Ala polymorphism is associated with higher HbA1C levels in T2DM patients.
|
27777960 |
2016 |