|
Thyroxine measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation.
|
30367059 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.060 |
GeneticVariation
|
BEFREE |
Homozygosity for the Dio2 Thr92Ala polymorphism is associated with higher HbA1C levels in T2DM patients.
|
27777960 |
2016 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.060 |
GeneticVariation
|
BEFREE |
In conclusion, the rs225017 polymorphism is associated with greater IR in T2DM and it seems to interact with the Thr92Ala polymorphism in the modulation of IR.
|
25105294 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.060 |
GeneticVariation
|
BEFREE |
The Thr92Ala variant common in Pima Indians, rs225011, and rs225015 were modestly associated with early-onset T2DM (p=0.01-0.04) in the case-control study, but were not associated with obesity in the obesity case-control study, nor associated with T2DM (at any age) or body-mass index (BMI; as a quantitative trait) in the family-based analysis.
|
22142372 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.060 |
GeneticVariation
|
BEFREE |
Association of the type 2 deiodinase Thr92Ala polymorphism with type 2 diabetes: case-control study and meta-analysis.
|
20566590 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.060 |
GeneticVariation
|
BEFREE |
The DIO2 Thr92Ala variant does not confer an increased risk of T2D, obesity, or insulin resistance.
|
17077128 |
2007 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.060 |
GeneticVariation
|
BEFREE |
An association among the Thr92Ala DIO2 variant and type 2 diabetes</span>, indices of insulin resistance (HOMA-IR), insulin secretion, free thyroid hormones, and thyrotropin (TSH) was found.
|
16356084 |
2005 |
|
Hypothyroidism
|
|
0.050 |
GeneticVariation
|
BEFREE |
One hypothesis is that a SNP (Thr92Ala) in DIO2 (required for local production of T3 out of T4) interferes with its kinetics and/or action, resulting in a local hypothyroid state in the brain.
|
31617166 |
2019 |
|
Hypothyroidism
|
|
0.050 |
GeneticVariation
|
BEFREE |
A new report indicates that carriers of the Thr92Ala-DIO2 polymorphism exhibit lower D2 catalytic activity and localized/systemic hypothyroidism.
|
30063552 |
2018 |
|
Hypothyroidism
|
|
0.050 |
GeneticVariation
|
BEFREE |
Thyroidectomized patients carrying Thr92Ala are at increased risk of reduced intracellular and serum T3 concentrations that are not adequately compensated for by LT4, thus providing evidence in favor of customized treatment of hypothyroidism in athyreotic patients.
|
28324063 |
2017 |
|
Hypothyroidism
|
|
0.050 |
GeneticVariation
|
BEFREE |
The present study indicates that the combination of polymorphisms in <i>DIO2</i> (rs225014) and <i>MCT10</i> (rs17606253) enhances hypothyroid patients' preference for L-T4 + L-T3 replacement therapy.
|
28785541 |
2017 |
|
Hypothyroidism
|
|
0.050 |
GeneticVariation
|
BEFREE |
A polymorphism (Thr92Ala) in the gene encoding the deiodinase 2 (D2) enzyme that converts thyroxine to triiodothyronine in the brain was later identified in about 16% of hypothyroid persons.
|
22548953 |
2013 |
|
Graves Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Seven SNPs in the DIO2 gene - rs225014 (Thr92Ala), rs12885300, rs2267872, rs225011, rs224995, rs225015, and rs2267873 - were studied to assess their association with GD and GO.
|
30574458 |
2018 |
|
Metabolic Syndrome X
|
|
0.030 |
GeneticVariation
|
BEFREE |
In both groups, the D2-Thr92Ala polymorphism was not associated with differences in TSH, fT4, fT3, the fT3/fT4 ratio, presence of metabolic syndrome or other comorbidities, use of medication, HRQoL, and cognitive functioning.
|
27786042 |
2017 |
|
Metabolic Syndrome X
|
|
0.030 |
GeneticVariation
|
BEFREE |
Recently, it was reported that the D2 Thr92Ala (rs225014) and the peroxisome proliferator-activated receptor (PPAR) γ2 Pro12Ala (rs1801282) polymorphisms interact in the modulation of metabolic syndrome in nondiabetic subjects.
|
20930717 |
2011 |
|
Graves Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Type 2 deiodinase Thr92Ala polymorphism impact on clinical course and myocardial remodeling in patients with Graves' disease.
|
19684474 |
2009 |
|
Metabolic Syndrome X
|
|
0.030 |
GeneticVariation
|
BEFREE |
Interaction of DIO2 T92A and PPARgamma2 P12A polymorphisms in the modulation of metabolic syndrome.
|
18198294 |
2007 |
|
Graves Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
This suggests that the Thr92Ala variant of the DIO2 gene is associated or may be in linkage disequilibrium with a functional DIO2 polymorphism which involves in the development of GD in a Russian population.
|
15542398 |
2004 |
|
Alzheimer's Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
In addition, African American carriers of Thr92Ala-DIO2 exhibit an about 30% higher risk of developing Alzheimer's disease.
|
30063552 |
2018 |
|
Hypertensive disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
There are a number of reports describing the association between the Thr92Ala-DIO2 polymorphism and clinical syndromes that include hypertension, type 2 diabetes, mental disorders, lung injury, bone turnover, and autoimmune thyroid disease; but these associations have not been reproduced in all population studies.
|
30063552 |
2018 |
|
Kashin-Beck Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
The meta-analysis of the GPX1 rs1050450, DIO2 rs225014, TrxR2 rs5748469 and HLA-DRB1 rs7745040 failed to reveal any associations with KBD.
|
27256326 |
2016 |
|
Kashin-Beck Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
In this study, we showed that single SNPs in the genes GPX1 (rs1050450, rs1800668 and rs3811699), TrxR2 (rs5748469), and DIO2 (rs225014) may not be significantly associated with KBD in a Tibetan population.
|
24058403 |
2013 |
|
Obesity
|
|
0.020 |
GeneticVariation
|
BEFREE |
The Thr92Ala variant common in Pima Indians, rs225011, and rs225015 were modestly associated with early-onset T2DM (p=0.01-0.04) in the case-control study, but were not associated with obesity in the obesity case-control study, nor associated with T2DM (at any age) or body-mass index (BMI; as a quantitative trait) in the family-based analysis.
|
22142372 |
2012 |
|
Hypertensive disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
The present study evaluated whether a type 2 iodothyronine deiodinase nonsynonymous polymorphism, threonine 92 to alanine (Thr92Ala), is a determinant of hypertension susceptibility.
|
17224473 |
2007 |
|
Obesity
|
|
0.020 |
GeneticVariation
|
BEFREE |
We detected no significant association of the DIO2 Thr92Ala polymorphism with T2D or obesity.
|
17077128 |
2007 |