|
Forced expiratory volume function
|
|
0.700 |
GeneticVariation
|
GWASCAT |
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
|
26634245 |
2015 |
|
response to bronchodilator
|
|
0.700 |
GeneticVariation
|
GWASCAT |
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
|
26634245 |
2015 |
|
Chronic Obstructive Airway Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
We found that -82G allele of SNP rs2276109 was associated with reduced risk of COPD, and COPD patients released more MMP-12 than healthy individuals, but independently on this SNP.
|
30658596 |
2019 |
|
Asthma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Due to limited information on this topic in the literature, we aimed to explore the possible role of polymorphisms in the promoter region of the macrophage elastase gene MMP12 82A>G (rs2276109) as a predisposing factor for BA in an ethnic Bulgarian population.
|
29390099 |
2018 |
|
Chronic Obstructive Airway Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results suggest that carriers of genotypes with at least one copy of minor G allele of rs2276109 might have lower risk for COPD development, with no marked effect on the lung function and severity of the disease.
|
28692348 |
2017 |
|
Asthma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The minor allele of a SNP in MMP12 (rs2276109) is associated with a positive effect on lung function in children with asthma and in adults who smoke.
|
20018959 |
2009 |
|
Ischemic stroke
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genotyping of seven single nucleotide polymorphisms (SNPs) of MMP genes (rs1799750, rs243865, rs3025058, rs11225395, rs17576, rs486055, and rs2276109) and eight genome-wide associated loci for IS were done using Taq-Man-based assays and MALDI-TOF mass spectrometry iPLEX platform, respectively.
|
31056794 |
2019 |
|
Presenile dementia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs2276109 and rs652438 allele and genotype frequencies were not associated with dementia in PD patients.
|
28655442 |
2018 |
|
PARKINSON DISEASE, LATE-ONSET
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs2276109 and rs652438 allele and genotype frequencies were not associated with dementia in PD patients.
|
28655442 |
2018 |
|
Dementia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs2276109 and rs652438 allele and genotype frequencies were not associated with dementia in PD patients.
|
28655442 |
2018 |
|
Rheumatic Heart Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
In contrast, rs3025058 in MMP3 and rs2276109 in MMP12 might not contribute to the risk of developing RHD in this population.
|
29458338 |
2018 |
|
Aortic Aneurysm, Abdominal
|
|
0.010 |
GeneticVariation
|
BEFREE |
No associations with AAA were identified for other SNPs assessed in this study including rs1799750 (MMP1), rs3918242 (MMP9), rs486055 (MMP10), rs2276109 (MMP12), rs2252070 (MMP13), rs4898 (TIMP1) or rs9619311 (TIMP3).
|
23813847 |
2014 |
|
Malignant neoplasm of urinary bladder
|
|
0.010 |
GeneticVariation
|
BEFREE |
To elucidate genetic polymorphisms of the matrix metalloproteinases (MMPs) MMP1 (rs1799750), MMP2 (rs243865), MMP9 (rs3918242), MMP12 (rs2276109) and tissue inhibitors of MMPs (TIMPs) TIMP1 (rs2070584) and TIMP3 (rs9619311) genes that may be involved in susceptibility to bladder cancer (BC).
|
23819551 |
2013 |
|
Carcinoma of bladder
|
|
0.010 |
GeneticVariation
|
BEFREE |
To elucidate genetic polymorphisms of the matrix metalloproteinases (MMPs) MMP1 (rs1799750), MMP2 (rs243865), MMP9 (rs3918242), MMP12 (rs2276109) and tissue inhibitors of MMPs (TIMPs) TIMP1 (rs2070584) and TIMP3 (rs9619311) genes that may be involved in susceptibility to bladder cancer (BC).
|
23819551 |
2013 |
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The results of this study suggest that the -82A →G (rs2276109) polymorphism of the MMP12 gene reflects clinical outcome of patients with CRC.
|
23898086 |
2013 |
|
Bladder Neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
To elucidate genetic polymorphisms of the matrix metalloproteinases (MMPs) MMP1 (rs1799750), MMP2 (rs243865), MMP9 (rs3918242), MMP12 (rs2276109) and tissue inhibitors of MMPs (TIMPs) TIMP1 (rs2070584) and TIMP3 (rs9619311) genes that may be involved in susceptibility to bladder cancer (BC).
|
23819551 |
2013 |
|
Congestive heart failure
|
|
0.010 |
GeneticVariation
|
BEFREE |
For MMP12 -82A>G (rs2276109), no pharmacogenetic effect was found for the primary outcome, although lower HRs were observed for AA homozygotes in the chlorthalidone-amlodipine comparison for HF (P = 0.015).
|
21887284 |
2011 |
|
Heart failure
|
|
0.010 |
GeneticVariation
|
BEFREE |
For MMP12 -82A>G (rs2276109), no pharmacogenetic effect was found for the primary outcome, although lower HRs were observed for AA homozygotes in the chlorthalidone-amlodipine comparison for HF (P = 0.015).
|
21887284 |
2011 |
|
Pulmonary Fibrosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The MMP-12 rs2276109 gene polymorphism may contribute to susceptibility to SSc, and in particular to dcSSc and pulmonary fibrosis.
|
20595276 |
2010 |
|
Systemic Scleroderma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The MMP-12 rs2276109 gene polymorphism may contribute to susceptibility to SSc, and in particular to dcSSc and pulmonary fibrosis.
|
20595276 |
2010 |