rs2282440, SDC3

N. diseases: 4
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
OBESITY, ASSOCIATION WITH
CUI: C4016383
Disease: OBESITY, ASSOCIATION WITH
0.700 GeneticVariation CLINVAR
Obesity
CUI: C0028754
Disease: Obesity
0.040 GeneticVariation BEFREE SDC3 rs2282440 TT homozygote had a 1.96-fold risk of being obese and 1.8-fold risk of having MetS (with CC genotype as reference). 29666642 2018
Obesity
CUI: C0028754
Disease: Obesity
0.040 GeneticVariation BEFREE We found that the rs2282440-SDC3T/T genotype is associated with obesity in the Taiwanese population. 27515755 2016
Obesity
CUI: C0028754
Disease: Obesity
0.040 GeneticVariation BEFREE We find that an infrequent genotype and allele variation of T329I correlated with obesity (p = 0.028). 19820907 2009
Obesity
CUI: C0028754
Disease: Obesity
0.040 GeneticVariation BEFREE Next, all three nonsynonymous SNPs [T271I (rs2282440, C>T), D245N (rs4949184, C>T), and V150I (rs2491132, C>T)] in the SDC3 gene in control female subjects (BMI < 23, n = 229) and obese female subjects (BMI > 30, n = 245) were genotyped. 17018662 2006
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.010 GeneticVariation BEFREE SDC3 rs2282440 polymorphism is positively associated with MetS in the Taiwanese population. 29666642 2018
Hyperandrogenism
CUI: C0206081
Disease: Hyperandrogenism
0.010 GeneticVariation BEFREE While infrequent variations of T329I correlated with obesity, V208I was associated with endocrine parameters related to hyperandrogenism. 19820907 2009