|
Adenocarcinoma Of Esophagus
|
|
0.010 |
GeneticVariation
|
BEFREE |
In a population-based case-control study, we examined associations of the COX-2 8473 T>C and iNOS Ser(608) Leu (C>T) polymorphisms with risk of esophageal adenocarcinoma, Barrett's esophagus, and reflux esophagitis.
|
18349295 |
2008 |
|
Ankylosing spondylitis
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci.
|
23749187 |
2013 |
|
Barrett Esophagus
|
|
0.010 |
GeneticVariation
|
BEFREE |
There was no significant association between this polymorphism and risk of Barrett's esophagus or reflux esophagitis or between the iNOS Ser 608 Leu polymorphism and risk of these esophageal conditions.
|
18349295 |
2008 |
|
Benign Prostatic Hyperplasia
|
|
0.010 |
GeneticVariation
|
BEFREE |
With a cohort of 205 controls and 229 BPH subjects, we genotyped three single nucleotide polymorphisms (SNPs) in the NOS2 gene, including rs2779248 (promoter, -278 T/C), rs10459953 (5'-untranslated region) and rs2297518 (exon 16, missense, Ser608Leu), using direct sequencing and restriction fragment length polymorphism.
|
20562898 |
2010 |
|
Carcinogenesis
|
|
0.020 |
GeneticVariation
|
BEFREE |
However, the NOS2 Ser608Leu polymorphism was not associated with gastric carcinogenesis.
|
20565800 |
2010 |
|
Carcinogenesis
|
|
0.020 |
GeneticVariation
|
BEFREE |
The roles of interleukin 8 (<i>IL8</i>) rs4073, nuclear factor kappa B (<i>NF</i>κ<i>B</i>) rs28362491, cytochrome b-245, alpha polypeptide (<i>CYBA</i>) rs4673, <i>NAD(P) H</i> dehydrogenase, quinone 1 (<i>NQO1</i>) rs1800566, nitric oxide synthase 2 and inducible (<i>NOS2</i>) rs2297518 polymorphisms in lung carcinogenesis were investigated.
|
28529598 |
2017 |
|
Chronic gastritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
SNP Ser608Leu was not associated with risk of chronic gastritis or gastric cancer.
|
20565800 |
2010 |
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Only NOS2A rs2297518 was associated with colon cancer (OR 0.86 95% CI 0.74, 0.99) and EPX rs2302313 and MPO rs2243828 were associated with rectal cancer (OR 0.75 95% CI 0.59, 0.96; OR 0.81 95% CI 0.67, 0.99 respectively) for main effects.
|
22531693 |
2012 |
|
Coronary heart disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Significant two-way SNP-SNP interactions were found between SNP rs2297518 and these two significant polymorphisms, affecting the risk of CHD (P<0.001 for both).
|
20581851 |
2010 |
|
Fibromyalgia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Given the reported association of nitric oxide synthase (NOS) gene polymorphisms with inflammatory disorders, we aimed to investigate the distribution of NOS2A -2.5 kb (CCTTT) n as well as Ser608Leu and NOS3 -786T>C variants and their correlation with nitrite/nitrate levels, in a study cohort including 170 MCS, 108 suspected MCS (SMCS), 89 FM/CFS, and 196 healthy subjects.
|
25878398 |
2015 |
|
Gastritis, Atrophic
|
|
0.010 |
GeneticVariation
|
BEFREE |
A nonsynonymous SNP of NOS2A (Ser608Leu) and an SNP located in the promoter of IFNGR1 (C-56T) were associated with higher risk of atrophic gastritis [odds ratio (OR)=1.37, 95% confidence interval (CI)=1.01-1.86, and OR=1.49, 95% CI=1.01-2.19, respectively].
|
18287876 |
2008 |
|
Gastro-esophageal reflux disease with esophagitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
There was no significant association between this polymorphism and risk of Barrett's esophagus or reflux esophagitis or between the iNOS Ser 608 Leu polymorphism and risk of these esophageal conditions.
|
18349295 |
2008 |
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
No significant associations between rs2297518 (G/A) variants alone and hypertension were found.
|
26579803 |
2015 |
|
Infection caused by Helicobacter pylori
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of this study was to evaluate the association of NOS2 polymorphisms Ser608Leu (rs2297518) in exon 16, -954G/C and -1173C/T, both in the promoter region, with gastric cancer and chronic gastritis and the association of cancer with risk factors such as smoking, alcohol intake and H. pylori infection.
|
20565800 |
2010 |
|
Liver Cirrhosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
One hundred and thirty-two patients with liver cirrhosis (age 36-72 years) and 101 controls were examined for functional variants of eNOS (E298D, 27bpintr4, 786T/C) and iNOS (R221W, S608L) genes.
|
23452051 |
2013 |
|
Lymphoma, Non-Hodgkin
|
|
0.010 |
GeneticVariation
|
BEFREE |
Specifically, for nitric oxide synthase (NOS2A Ser608Leu, rs2297518) Leu/Leu homozygotes, there was a 2-fold risk increase for NHL (OR=2.2, 95% CI=1.1-4.4) (referent=Ser/Ser and Ser/Leu).
|
16543247 |
2006 |
|
Lymphoma, Non-Hodgkin
|
|
0.010 |
GeneticVariation
|
BEFREE |
Specifically, for nitric oxide synthase (NOS2A Ser608Leu, rs2297518) Leu/Leu homozygotes, there was a 2-fold risk increase for NHL (OR=2.2, 95% CI=1.1-4.4) (referent=Ser/Ser and Ser/Leu).
|
16543247 |
2006 |
|
Malignant neoplasm of prostate
|
|
0.010 |
GeneticVariation
|
BEFREE |
We evaluated the association of prostate cancer with genetic polymorphisms in two genes related to intracellular NO: NOS2A [inducible nitric oxide synthase (NOS); -2892T>C, Ex16 + 14C>T (S608L), IVS16 + 88T>G and IVS20 + 524G>A] and NOS3 [endothelial NOS; IVS1-762C>T, Ex7-43C>T (D258D), IVS7-26A>G, Ex8-63G>T (E298D) and IVS15-62G>T].
|
19168583 |
2009 |
|
Malignant neoplasm of stomach
|
|
0.020 |
GeneticVariation
|
BEFREE |
SNP Ser608Leu was not associated with risk of chronic gastritis or gastric cancer.
|
20565800 |
2010 |
|
Malignant neoplasm of stomach
|
|
0.020 |
GeneticVariation
|
BEFREE |
<i>iNOS</i> rs2297518 and <i>eNOS</i> rs2070744 polymorphisms may represent susceptible factors for gastric cancer.
|
29765229 |
2018 |
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
The results indicated that the polymorphisms in iNOS gene (C150T(Ser(608) Leu) polymorphism and polymorphic (CCTTT)n repeats) had no association with cancer risk for all genetic models.
|
26391304 |
2015 |
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
The aim of this study was to evaluate the association of NOS2 polymorphisms Ser608Leu (rs2297518) in exon 16, -954G/C and -1173C/T, both in the promoter region, with gastric cancer and chronic gastritis and the association of cancer with risk factors such as smoking, alcohol intake and H. pylori infection.
|
20565800 |
2010 |
|
Malignant tumor of colon
|
|
0.010 |
GeneticVariation
|
BEFREE |
Only NOS2A rs2297518 was associated with colon cancer (OR 0.86 95% CI 0.74, 0.99) and EPX rs2302313 and MPO rs2243828 were associated with rectal cancer (OR 0.75 95% CI 0.59, 0.96; OR 0.81 95% CI 0.67, 0.99 respectively) for main effects.
|
22531693 |
2012 |
|
Mast-Cell Sarcoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Given the reported association of nitric oxide synthase (NOS) gene polymorphisms with inflammatory disorders, we aimed to investigate the distribution of NOS2A -2.5 kb (CCTTT) n as well as Ser608Leu and NOS3 -786T>C variants and their correlation with nitrite/nitrate levels, in a study cohort including 170 MCS, 108 suspected MCS (SMCS), 89 FM/CFS, and 196 healthy subjects.
|
25878398 |
2015 |
|
Migraine Disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
We tested the hypothesis that two functional, clinically relevant iNOS genetic polymorphisms (C(-1026)A-rs2779249 and G2087A-rs2297518) are associated with migraine with or without aura.
|
22234503 |
2012 |