|
Lymphoma, Non-Hodgkin
|
|
0.010 |
GeneticVariation
|
BEFREE |
Specifically, for nitric oxide synthase (NOS2A Ser608Leu, rs2297518) Leu/Leu homozygotes, there was a 2-fold risk increase for NHL (OR=2.2, 95% CI=1.1-4.4) (referent=Ser/Ser and Ser/Leu).
|
16543247 |
2006 |
|
Chronic gastritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
SNP Ser608Leu was not associated with risk of chronic gastritis or gastric cancer.
|
20565800 |
2010 |
|
Migraine Disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
We tested the hypothesis that two functional, clinically relevant iNOS genetic polymorphisms (C(-1026)A-rs2779249 and G2087A-rs2297518) are associated with migraine with or without aura.
|
22234503 |
2012 |
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Only NOS2A rs2297518 was associated with colon cancer (OR 0.86 95% CI 0.74, 0.99) and EPX rs2302313 and MPO rs2243828 were associated with rectal cancer (OR 0.75 95% CI 0.59, 0.96; OR 0.81 95% CI 0.67, 0.99 respectively) for main effects.
|
22531693 |
2012 |
|
Benign Prostatic Hyperplasia
|
|
0.010 |
GeneticVariation
|
BEFREE |
With a cohort of 205 controls and 229 BPH subjects, we genotyped three single nucleotide polymorphisms (SNPs) in the NOS2 gene, including rs2779248 (promoter, -278 T/C), rs10459953 (5'-untranslated region) and rs2297518 (exon 16, missense, Ser608Leu), using direct sequencing and restriction fragment length polymorphism.
|
20562898 |
2010 |
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
No significant associations between rs2297518 (G/A) variants alone and hypertension were found.
|
26579803 |
2015 |
|
Gastritis, Atrophic
|
|
0.010 |
GeneticVariation
|
BEFREE |
A nonsynonymous SNP of NOS2A (Ser608Leu) and an SNP located in the promoter of IFNGR1 (C-56T) were associated with higher risk of atrophic gastritis [odds ratio (OR)=1.37, 95% confidence interval (CI)=1.01-1.86, and OR=1.49, 95% CI=1.01-2.19, respectively].
|
18287876 |
2008 |
|
Malignant neoplasm of prostate
|
|
0.010 |
GeneticVariation
|
BEFREE |
We evaluated the association of prostate cancer with genetic polymorphisms in two genes related to intracellular NO: NOS2A [inducible nitric oxide synthase (NOS); -2892T>C, Ex16 + 14C>T (S608L), IVS16 + 88T>G and IVS20 + 524G>A] and NOS3 [endothelial NOS; IVS1-762C>T, Ex7-43C>T (D258D), IVS7-26A>G, Ex8-63G>T (E298D) and IVS15-62G>T].
|
19168583 |
2009 |
|
Gastro-esophageal reflux disease with esophagitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
There was no significant association between this polymorphism and risk of Barrett's esophagus or reflux esophagitis or between the iNOS Ser 608 Leu polymorphism and risk of these esophageal conditions.
|
18349295 |
2008 |
|
Adenocarcinoma Of Esophagus
|
|
0.010 |
GeneticVariation
|
BEFREE |
In a population-based case-control study, we examined associations of the COX-2 8473 T>C and iNOS Ser(608) Leu (C>T) polymorphisms with risk of esophageal adenocarcinoma, Barrett's esophagus, and reflux esophagitis.
|
18349295 |
2008 |
|
Ankylosing spondylitis
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci.
|
23749187 |
2013 |