|
Malignant neoplasm of breast
|
|
0.770 |
GeneticVariation
|
BEFREE |
This meta-analysis of case-control studies provides strong evidence that FGFR2 (rs2981582, rs2420946 and rs2981578) polymorphisms were significantly associated with the BC risk.
|
27966449 |
2017 |
|
Breast Carcinoma
|
|
0.770 |
GeneticVariation
|
BEFREE |
This meta-analysis of case-control studies provides strong evidence that FGFR2 (rs2981582, rs2420946 and rs2981578) polymorphisms were significantly associated with the BC risk.
|
27966449 |
2017 |
|
Malignant neoplasm of breast
|
|
0.770 |
GeneticVariation
|
BEFREE |
Significant associations with breast cancer risk were observed for rs2420946, rs2981579, and rs2981582 with OR (95% CI) per risk allele of 1.19 (1.03-1.39), 1.24 (1.07-1.43), and 1.17 (1.01-1.36), respectively.
|
26421298 |
2015 |
|
Breast Carcinoma
|
|
0.770 |
GeneticVariation
|
BEFREE |
Significant associations with breast cancer risk were observed for rs2420946, rs2981579, and rs2981582 with OR (95% CI) per risk allele of 1.19 (1.03-1.39), 1.24 (1.07-1.43), and 1.17 (1.01-1.36), respectively.
|
26421298 |
2015 |
|
Breast Carcinoma
|
|
0.770 |
GeneticVariation
|
GWASCAT |
Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk.
|
23544012 |
2013 |
|
Malignant neoplasm of breast
|
|
0.770 |
GeneticVariation
|
BEFREE |
In the haplotype analysis, the FGFR2 rs2981582 T / rs2420946 T / rs1219648 G haplotype (ht2) was associated with a significantly increased BC risk compared with the rs2981582 C / rs2420946 C / rs1219648 A haplotype in familial BC and in non-familial early-onset BC (OR = 1.32, 95 % CI 1.06-1.65, P = 0.012; OR = 1.46, 95 % CI 1.11-1.91, P = 0.004, respectively).
|
23225170 |
2013 |
|
Breast Carcinoma
|
|
0.770 |
GeneticVariation
|
BEFREE |
To investigate this inconsistency, we performed a meta-analysis of 37 studies involving a total of 288,142 subjects for rs2981582, rs1219648, and rs2420946 polymorphism of the FGFR2 gene to evaluate the effect of FGFR2 on genetic susceptibility for BC.
|
23184080 |
2013 |
|
Malignant neoplasm of breast
|
|
0.770 |
GeneticVariation
|
BEFREE |
To investigate this inconsistency, we performed a meta-analysis of 37 studies involving a total of 288,142 subjects for rs2981582, rs1219648, and rs2420946 polymorphism of the FGFR2 gene to evaluate the effect of FGFR2 on genetic susceptibility for BC.
|
23184080 |
2013 |
|
Breast Carcinoma
|
|
0.770 |
GeneticVariation
|
BEFREE |
In the haplotype analysis, the FGFR2 rs2981582 T / rs2420946 T / rs1219648 G haplotype (ht2) was associated with a significantly increased BC risk compared with the rs2981582 C / rs2420946 C / rs1219648 A haplotype in familial BC and in non-familial early-onset BC (OR = 1.32, 95 % CI 1.06-1.65, P = 0.012; OR = 1.46, 95 % CI 1.11-1.91, P = 0.004, respectively).
|
23225170 |
2013 |
|
Malignant neoplasm of breast
|
|
0.770 |
GeneticVariation
|
BEFREE |
Three commonly studied FGFR2 polymorphisms including rs1219648 (A > G), rs2420946 (C > T), and rs2981582 (C > T) were selected to explore their association with risk of development of breast cancer by meta-analysis of published case-control studies.
|
20300826 |
2010 |
|
Breast Carcinoma
|
|
0.770 |
GeneticVariation
|
BEFREE |
In conclusion, this meta-analysis suggests that rs2981582, rs1219648, and rs2420946 polymorphisms in FGFR2 are associated with elevated BC risk.
|
20364400 |
2010 |
|
Breast Carcinoma
|
|
0.770 |
GeneticVariation
|
BEFREE |
Three commonly studied FGFR2 polymorphisms including rs1219648 (A > G), rs2420946 (C > T), and rs2981582 (C > T) were selected to explore their association with risk of development of breast cancer by meta-analysis of published case-control studies.
|
20300826 |
2010 |
|
Malignant neoplasm of breast
|
|
0.770 |
GeneticVariation
|
BEFREE |
In conclusion, this meta-analysis suggests that rs2981582, rs1219648, and rs2420946 polymorphisms in FGFR2 are associated with elevated BC risk.
|
20364400 |
2010 |
|
Breast Carcinoma
|
|
0.770 |
GeneticVariation
|
BEFREE |
We observed a statistically significant association between 4 SNPs and breast cancer risk and these 4 SNPs were in strong linkage disequilibrium in the Japanese population. rs2420946 was associated with a population-attributable risk of 17.7%.
|
19582883 |
2009 |
|
Malignant neoplasm of breast
|
|
0.770 |
GeneticVariation
|
BEFREE |
We observed a statistically significant association between 4 SNPs and breast cancer risk and these 4 SNPs were in strong linkage disequilibrium in the Japanese population. rs2420946 was associated with a population-attributable risk of 17.7%.
|
19582883 |
2009 |
|
Malignant neoplasm of breast
|
|
0.770 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies novel breast cancer susceptibility loci.
|
17529967 |
2007 |
|
Malignant neoplasm of breast
|
|
0.770 |
GeneticVariation
|
GWASDB |
A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer.
|
17529973 |
2007 |
|
Osteoporosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Besides, the significant interaction of <i>FGFR2</i> polymorphisms with drinking status in osteoporosis was also found (<i>P</i><0.05), especially rs2981579.<b>Conclusion:</b><i>FGFR2</i> rs2420946 and rs1219648 polymorphisms may be the risk factor of osteoporosis in Chinese population.
|
31113874 |
2019 |
|
Breast Cancer, Familial
|
|
0.010 |
GeneticVariation
|
BEFREE |
The data showed that the homozygotes at each minor allele, rs11200014 (AA), rs1219648 (GG), rs2420946 (TT), and rs2981582 (TT), were significantly associated with an increased risk of early-onset non-familial breast cancer.
|
22374580 |
2012 |