|
Psychotic Disorders
|
|
0.050 |
GeneticVariation
|
BEFREE |
These findings did not provide evidence of a possible role of COMT Val<sup>158</sup>Met, AKT1 rs2494732 or DRD2 rs1076560 genotypes in modifying the association between childhood adversity and onset of psychosis.
|
29653893 |
2019 |
|
Psychotic Disorders
|
|
0.050 |
GeneticVariation
|
BEFREE |
While rs2494732 was associated with the presence of psychosis (group-2, 3 and 4), rs2498804 was associated with affective symptoms (groups-1, 2 and 3).
|
22277669 |
2012 |
|
Psychotic Disorders
|
|
0.050 |
GeneticVariation
|
BEFREE |
Our findings provide strong support for the initial report that genetic variation at rs2494732 of AKT1 influences the risk of developing a psychotic disorder in cannabis users.
|
22831980 |
2012 |
|
Psychotic Disorders
|
|
0.050 |
GeneticVariation
|
BEFREE |
Follow-up analysis supported AKT1 rs2494732 × cannabis interaction in the case-only (β = 0.20; P = .007), case-sibling (interaction P = .040), and case-control (interaction P = .057) analyses, with individuals with C/C genotypes having an approximately 2-fold odds of being diagnosed with a psychotic disorder when having used cannabis.
|
21041608 |
2011 |
|
Psychotic Disorders
|
|
0.050 |
GeneticVariation
|
BEFREE |
Cannabis use preceding onset of psychotic disorder did interact significantly with AKT1 rs2494732 genotype to affect CPT reaction time (β=8.0, SE 3.9, p=0.037) and CPT accuracy (β=-1.2, SE 0.4, p=0.003).
|
21775978 |
2011 |
|
Cannabis use
|
|
0.040 |
GeneticVariation
|
BEFREE |
We examined the gender and cannabis use-adjusted association between BDNF rs6265 [G>A] and AKT1 rs2494732 [T>C] and AoP.
|
31445421 |
2019 |
|
Marijuana Abuse
|
|
0.040 |
GeneticVariation
|
BEFREE |
Variation at the rs2494732 locus of the AKT1 gene predicted acute psychotic response to cannabis along with dependence on the drug and baseline schizotypal symptoms.
|
26882038 |
2016 |
|
Marijuana Abuse
|
|
0.040 |
GeneticVariation
|
BEFREE |
Moreover, out of 6 AKT1 SNPs, rs2494732 was associated with cannabis use, but AKT1 did not mediate the effect of cannabis on BMI.
|
27554198 |
2016 |
|
Cannabis use
|
|
0.040 |
GeneticVariation
|
BEFREE |
Moreover, out of 6 AKT1 SNPs, rs2494732 was associated with cannabis use, but AKT1 did not mediate the effect of cannabis on BMI.
|
27554198 |
2016 |
|
Marijuana Abuse
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our findings provide strong support for the initial report that genetic variation at rs2494732 of AKT1 influences the risk of developing a psychotic disorder in cannabis users.
|
22831980 |
2012 |
|
Cannabis use
|
|
0.040 |
GeneticVariation
|
BEFREE |
In a case-control study of 489 first-episode psychosis patients and 278 control subjects, we investigated the interaction between variation at the AKT1 rs2494732 single nucleotide polymorphism and cannabis use in increasing the risk of psychosis.
|
22831980 |
2012 |
|
Cannabis use
|
|
0.040 |
GeneticVariation
|
BEFREE |
Cannabis use preceding onset of psychotic disorder did interact significantly with AKT1 rs2494732 genotype to affect CPT reaction time (β=8.0, SE 3.9, p=0.037) and CPT accuracy (β=-1.2, SE 0.4, p=0.003).
|
21775978 |
2011 |
|
Marijuana Abuse
|
|
0.040 |
GeneticVariation
|
BEFREE |
Follow-up analysis supported AKT1 rs2494732 × cannabis interaction in the case-only (β = 0.20; P = .007), case-sibling (interaction P = .040), and case-control (interaction P = .057) analyses, with individuals with C/C genotypes having an approximately 2-fold odds of being diagnosed with a psychotic disorder when having used cannabis.
|
21041608 |
2011 |
|
Nonorganic psychosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
These findings did not provide evidence of a possible role of COMT Val<sup>158</sup>Met, AKT1 rs2494732 or DRD2 rs1076560 genotypes in modifying the association between childhood adversity and onset of psychosis.
|
29653893 |
2019 |
|
Schizophrenia
|
|
0.030 |
GeneticVariation
|
BEFREE |
A meta-analysis of the associations between genetic variants in the AKT1 gene and schizophrenia found that a single nucleotide polymorphism (SNP5; rs2494732) was associated with schizophrenia in Asian populations.
|
22150081 |
2013 |
|
Nonorganic psychosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
In a case-control study of 489 first-episode psychosis patients and 278 control subjects, we investigated the interaction between variation at the AKT1 rs2494732 single nucleotide polymorphism and cannabis use in increasing the risk of psychosis.
|
22831980 |
2012 |
|
Nonorganic psychosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
While rs2494732 was associated with the presence of psychosis (group-2, 3 and 4), rs2498804 was associated with affective symptoms (groups-1, 2 and 3).
|
22277669 |
2012 |
|
Schizophrenia
|
|
0.030 |
GeneticVariation
|
BEFREE |
The same five SNPs used in previous studies of the etiology of schizophrenia (rs2494732, rs2498799, rs3730358, rs1130214, [corrected] and rs3803300) were genotyped in 641 individuals with schizophrenia who had participated in the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) project.
|
17464696 |
2007 |
|
Schizophrenia
|
|
0.030 |
GeneticVariation
|
BEFREE |
Five single-nucleotide polymorphisms, rs3803300, rs1130214, rs3730358, rs2498799 and rs2494732, at the genomic region of AKT1 have been reported to be significantly associated with schizophrenia.
|
16395129 |
2006 |
|
Malignant neoplasm of prostate
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study investigated the associations between three polymorphisms (rs1130214, rs3730358, and rs2494732) in AKT1 and the risk of development of prostate cancer in the Chinese Han population.
|
28363000 |
2017 |
|
Prostate carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study investigated the associations between three polymorphisms (rs1130214, rs3730358, and rs2494732) in AKT1 and the risk of development of prostate cancer in the Chinese Han population.
|
28363000 |
2017 |
|
Parkinson Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genetic variants of AKT1 have been shown to influence brain function of Parkinson's disease (PD) patients, and in this paper our aim is to investigate the association between the three single-nucleotide polymorphisms (rs2498799; rs2494732; rs1130214) and PD in Han Chinese.
|
27353512 |
2016 |
|
PARKINSON DISEASE, LATE-ONSET
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genetic variants of AKT1 have been shown to influence brain function of Parkinson's disease (PD) patients, and in this paper our aim is to investigate the association between the three single-nucleotide polymorphisms (rs2498799; rs2494732; rs1130214) and PD in Han Chinese.
|
27353512 |
2016 |
|
Metastatic malignant neoplasm to brain
|
|
0.010 |
GeneticVariation
|
BEFREE |
In analysis of individual SNPs, the GT/GG genotype of AKT1: rs2498804, CT/TT genotype of AKT1: rs2494732, and AG/AA genotype of PIK3CA: rs2699887 were associated with higher risk of brain metastasis at 24-month follow-up [respective HRs, 1.860, 95% confidence interval (CI) 1.199-2.885, P = 0.006; HR 1.902, 95% CI 1.259-2.875, P = 0.002; and HR 1.933, 95% CI 1.168-3.200, P = 0.010].
|
24077347 |
2013 |
|
Affective Symptoms
|
|
0.010 |
GeneticVariation
|
BEFREE |
While rs2494732 was associated with the presence of psychosis (group-2, 3 and 4), rs2498804 was associated with affective symptoms (groups-1, 2 and 3).
|
22277669 |
2012 |