|
Crohn Disease
|
|
0.880 |
GeneticVariation
|
BEFREE |
PTPN2 (rs2542151) was only associated in the smoking CD cohort (P=0.041), and not in the entire cohort (P=0.23) or in the non-smoking CD cohort (P=0.80).
|
19953089 |
2010 |
|
Crohn Disease
|
|
0.880 |
GeneticVariation
|
BEFREE |
The single nucleotide polymorphism (SNP) rs1893217 within the gene locus encoding protein tyrosine phosphatase non-receptor type 2 (PTPN2) results in a dysfunctional PTPN2 protein is associated with Crohn's disease (CD) and exists in perfect linkage disequilibrium with the CD- and ulcerative colitis (UC)-associated PTPN2 SNP rs2542151.
|
26928573 |
2016 |
|
Crohn Disease
|
|
0.880 |
GeneticVariation
|
BEFREE |
The study indicates that IL23R-rs11805303 and PTPN2-rs2542151 might contribute to the development of UC and NOD2-P268S might be involved in the etiology of CD in the Chinese Han population.
|
22426692 |
2012 |
|
Crohn Disease
|
|
0.880 |
GeneticVariation
|
BEFREE |
In stage 1, we observed associations between 5 intronic SNPs and CD including rs1893217 (P = 2 × 10⁻⁴), the SNP that is in perfect linkage disequilibrium with the lead genome-wide association studies SNP rs2542151.
|
23518806 |
2013 |
|
Crohn Disease
|
|
0.880 |
GeneticVariation
|
BEFREE |
Both rs2542151 and rs2542152 are associated with CD, but not ulcerative colitis (UC). mRNA expression levels of PTPN2 were significantly increased in intestinal tissues (p=0.0493), and nearly significantly increased in B cells (p=0.0889) from CD patients, but not significantly altered in UC. cDNA microarray results found that PTPN2 was down-regulated by NKX2-3 knockdown in human cells.
|
22377701 |
2012 |
|
Crohn Disease
|
|
0.880 |
GeneticVariation
|
BEFREE |
The single nucleotide polymorphism (SNP) rs2542151 within the gene locus region encoding protein tyrosine phosphatase non-receptor type 2 (PTPN2) has been associated with Crohn's disease (CD), ulcerative colitis (UC), type-I diabetes, and rheumatoid arthritis.
|
22021207 |
2012 |
|
Crohn Disease
|
|
0.880 |
GeneticVariation
|
BEFREE |
Significant associations were found between rs2542151 polymorphism and CD susceptibility (OR = 1.22, 95 % CI, 1.15-1.30, I (2) = 32 %), as well as between rs2542151 and UC susceptibility (OR = 1.16, 95 % CI, 1.07-1.25, I (2) = 39 %).
|
24127071 |
2014 |
|
Crohn Disease
|
|
0.880 |
GeneticVariation
|
BEFREE |
Our analysis revealed a significant association of PTPN2 SNP rs2542151 with both susceptibility to CD (p = 1.95×10⁻⁵; OR 1.49 [1.34-1.79]) and UC (p = 3.87×10⁻², OR 1.31 [1.02-1.68]).
|
22457781 |
2012 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.830 |
GeneticVariation
|
BEFREE |
We genotyped 439 T1D Spanish subjects (age at onset, 1 to 65 years) and 861 controls for two PTPN2 single nucleotide polymorphisms (SNPs), rs2542151 and rs478582, and studied the effect of both polymorphisms in age at onset through stratified and continuous analyses.
|
21246196 |
2011 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.830 |
GeneticVariation
|
BEFREE |
The single nucleotide polymorphism (SNP) rs2542151 within the gene locus region encoding protein tyrosine phosphatase non-receptor type 2 (PTPN2) has been associated with Crohn's disease (CD), ulcerative colitis (UC), type-I diabetes, and rheumatoid arthritis.
|
22021207 |
2012 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.830 |
GeneticVariation
|
BEFREE |
The findings suggested that rs2542151 SNP in The PTPN2 gene was associated with T1DM in Chinese Han children.
|
26344020 |
2015 |
|
Ulcerative Colitis
|
|
0.060 |
GeneticVariation
|
BEFREE |
The study indicates that IL23R-rs11805303 and PTPN2-rs2542151 might contribute to the development of UC and NOD2-P268S might be involved in the etiology of CD in the Chinese Han population.
|
22426692 |
2012 |
|
Ulcerative Colitis
|
|
0.060 |
GeneticVariation
|
BEFREE |
Our analysis revealed a significant association of PTPN2 SNP rs2542151 with both susceptibility to CD (p = 1.95×10⁻⁵; OR 1.49 [1.34-1.79]) and UC (p = 3.87×10⁻², OR 1.31 [1.02-1.68]).
|
22457781 |
2012 |
|
Ulcerative Colitis
|
|
0.060 |
GeneticVariation
|
BEFREE |
The single nucleotide polymorphism (SNP) rs2542151 within the gene locus region encoding protein tyrosine phosphatase non-receptor type 2 (PTPN2) has been associated with Crohn's disease (CD), ulcerative colitis (UC), type-I diabetes, and rheumatoid arthritis.
|
22021207 |
2012 |
|
Ulcerative Colitis
|
|
0.060 |
GeneticVariation
|
BEFREE |
The single nucleotide polymorphism (SNP) rs1893217 within the gene locus encoding protein tyrosine phosphatase non-receptor type 2 (PTPN2) results in a dysfunctional PTPN2 protein is associated with Crohn's disease (CD) and exists in perfect linkage disequilibrium with the CD- and ulcerative colitis (UC)-associated PTPN2 SNP rs2542151.
|
26928573 |
2016 |
|
Ulcerative Colitis
|
|
0.060 |
GeneticVariation
|
BEFREE |
Both rs2542151 and rs2542152 are associated with CD, but not ulcerative colitis (UC). mRNA expression levels of PTPN2 were significantly increased in intestinal tissues (p=0.0493), and nearly significantly increased in B cells (p=0.0889) from CD patients, but not significantly altered in UC. cDNA microarray results found that PTPN2 was down-regulated by NKX2-3 knockdown in human cells.
|
22377701 |
2012 |
|
Ulcerative Colitis
|
|
0.060 |
GeneticVariation
|
BEFREE |
Significant associations were found between rs2542151 polymorphism and CD susceptibility (OR = 1.22, 95 % CI, 1.15-1.30, I (2) = 32 %), as well as between rs2542151 and UC susceptibility (OR = 1.16, 95 % CI, 1.07-1.25, I (2) = 39 %).
|
24127071 |
2014 |
|
Rheumatoid Arthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The single nucleotide polymorphism (SNP) rs2542151 within the gene locus region encoding protein tyrosine phosphatase non-receptor type 2 (PTPN2) has been associated with Crohn's disease (CD), ulcerative colitis (UC), type-I diabetes, and rheumatoid arthritis.
|
22021207 |
2012 |
|
Behcet Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
PTPN2 rs1893217 was associated with risk of developing BD (χ2=10.01, pc=0.040), while the PTPN2 rs2542151 genotype had a weak association in basic genotype analysis (χ2=7.49, p=0.024), but it could not withstand the strongest Bonferroni correction (pc=0.14).
|
24480412 |
2014 |
|
Ankylosing spondylitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Polymorphisms associated in the allele frequencies test with severe BASFI/t in all classifications were: rs2542151 (p60 [P = .04], p65 [P = .04], p70 [P = .001] and p75 [P = .001]) and rs2254441 (p60 [P = .004], p65 [P = .02], p70 [P = .01] and p75 [P<.001]).. Genotype association, after adjustment for covariates, found an association in three of the four patients' classifications for rs2542151 and in two of the classifications for rs2254441.Forward logistic regression did not identify any model with a good predictive power for severe functional development.In our study we identified clinical factors and 24 polymorphisms associated with development of severe functional status in AS patients.
|
22984424 |
2012 |
|
Inflammatory Bowel Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genomic DNA from 2131 individuals of Caucasian origin (905 patients with CD, 318 patients with UC, and 908 healthy, unrelated controls) was analyzed for two SNPs in the PTPN2 region (rs2542151, rs7234029) for which associations with IBD were found in previous studies in other cohorts.
|
22457781 |
2012 |
|
Crohn Disease
|
|
0.880 |
GeneticVariation
|
GWASCAT |
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility.
|
17554261 |
2007 |
|
Crohn Disease
|
|
0.880 |
GeneticVariation
|
GWASCAT |
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
|
18587394 |
2008 |
|
Crohn Disease
|
|
0.880 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
|
17554300 |
2007 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.830 |
GeneticVariation
|
GWASCAT |
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.
|
18978792 |
2008 |