|
Crohn Disease
|
|
0.880 |
GeneticVariation
|
BEFREE |
The single nucleotide polymorphism (SNP) rs1893217 within the gene locus encoding protein tyrosine phosphatase non-receptor type 2 (PTPN2) results in a dysfunctional PTPN2 protein is associated with Crohn's disease (CD) and exists in perfect linkage disequilibrium with the CD- and ulcerative colitis (UC)-associated PTPN2 SNP rs2542151.
|
26928573 |
2016 |
|
Crohn Disease
|
|
0.880 |
GeneticVariation
|
BEFREE |
Significant associations were found between rs2542151 polymorphism and CD susceptibility (OR = 1.22, 95 % CI, 1.15-1.30, I (2) = 32 %), as well as between rs2542151 and UC susceptibility (OR = 1.16, 95 % CI, 1.07-1.25, I (2) = 39 %).
|
24127071 |
2014 |
|
Crohn Disease
|
|
0.880 |
GeneticVariation
|
BEFREE |
In stage 1, we observed associations between 5 intronic SNPs and CD including rs1893217 (P = 2 × 10⁻⁴), the SNP that is in perfect linkage disequilibrium with the lead genome-wide association studies SNP rs2542151.
|
23518806 |
2013 |
|
Crohn Disease
|
|
0.880 |
GeneticVariation
|
BEFREE |
The study indicates that IL23R-rs11805303 and PTPN2-rs2542151 might contribute to the development of UC and NOD2-P268S might be involved in the etiology of CD in the Chinese Han population.
|
22426692 |
2012 |
|
Crohn Disease
|
|
0.880 |
GeneticVariation
|
BEFREE |
Both rs2542151 and rs2542152 are associated with CD, but not ulcerative colitis (UC). mRNA expression levels of PTPN2 were significantly increased in intestinal tissues (p=0.0493), and nearly significantly increased in B cells (p=0.0889) from CD patients, but not significantly altered in UC. cDNA microarray results found that PTPN2 was down-regulated by NKX2-3 knockdown in human cells.
|
22377701 |
2012 |
|
Crohn Disease
|
|
0.880 |
GeneticVariation
|
BEFREE |
The single nucleotide polymorphism (SNP) rs2542151 within the gene locus region encoding protein tyrosine phosphatase non-receptor type 2 (PTPN2) has been associated with Crohn's disease (CD), ulcerative colitis (UC), type-I diabetes, and rheumatoid arthritis.
|
22021207 |
2012 |
|
Crohn Disease
|
|
0.880 |
GeneticVariation
|
BEFREE |
Our analysis revealed a significant association of PTPN2 SNP rs2542151 with both susceptibility to CD (p = 1.95×10⁻⁵; OR 1.49 [1.34-1.79]) and UC (p = 3.87×10⁻², OR 1.31 [1.02-1.68]).
|
22457781 |
2012 |
|
Crohn Disease
|
|
0.880 |
GeneticVariation
|
GWASDB |
A meta-analysis of genome-wide association scans identifies IL18RAP, PTPN2, TAGAP, and PUS10 as shared risk loci for Crohn's disease and celiac disease.
|
21298027 |
2011 |
|
Crohn Disease
|
|
0.880 |
GeneticVariation
|
BEFREE |
PTPN2 (rs2542151) was only associated in the smoking CD cohort (P=0.041), and not in the entire cohort (P=0.23) or in the non-smoking CD cohort (P=0.80).
|
19953089 |
2010 |
|
Crohn Disease
|
|
0.880 |
GeneticVariation
|
GWASDB |
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
|
18587394 |
2008 |
|
Crohn Disease
|
|
0.880 |
GeneticVariation
|
GWASCAT |
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
|
18587394 |
2008 |
|
Crohn Disease
|
|
0.880 |
GeneticVariation
|
GWASCAT |
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility.
|
17554261 |
2007 |
|
Crohn Disease
|
|
0.880 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
|
17554300 |
2007 |
|
Crohn Disease
|
|
0.880 |
GeneticVariation
|
GWASDB |
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
|
17554300 |
2007 |
|
Crohn Disease
|
|
0.880 |
GeneticVariation
|
GWASDB |
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility.
|
17554261 |
2007 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.830 |
GeneticVariation
|
BEFREE |
The findings suggested that rs2542151 SNP in The PTPN2 gene was associated with T1DM in Chinese Han children.
|
26344020 |
2015 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.830 |
GeneticVariation
|
BEFREE |
The single nucleotide polymorphism (SNP) rs2542151 within the gene locus region encoding protein tyrosine phosphatase non-receptor type 2 (PTPN2) has been associated with Crohn's disease (CD), ulcerative colitis (UC), type-I diabetes, and rheumatoid arthritis.
|
22021207 |
2012 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.830 |
GeneticVariation
|
BEFREE |
We genotyped 439 T1D Spanish subjects (age at onset, 1 to 65 years) and 861 controls for two PTPN2 single nucleotide polymorphisms (SNPs), rs2542151 and rs478582, and studied the effect of both polymorphisms in age at onset through stratified and continuous analyses.
|
21246196 |
2011 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.830 |
GeneticVariation
|
GWASCAT |
Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
|
21829393 |
2011 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.830 |
GeneticVariation
|
GWASCAT |
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.
|
18978792 |
2008 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.830 |
GeneticVariation
|
GWASDB |
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.
|
18978792 |
2008 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.830 |
GeneticVariation
|
GWASCAT |
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.
|
17554260 |
2007 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.830 |
GeneticVariation
|
GWASDB |
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.
|
17554260 |
2007 |
|
Juvenile arthritis
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide association analysis of juvenile idiopathic arthritis identifies a new susceptibility locus at chromosomal region 3q13.
|
22354554 |
2012 |
|
Asthma
|
|
0.700 |
GeneticVariation
|
GWASDB |
Association between ORMDL3, IL1RL1 and a deletion on chromosome 17q21 with asthma risk in Australia.
|
21150878 |
2011 |