|
Adult Myelodysplastic Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association of XPD (Lys751Gln) and XRCC1 (Arg280His) gene polymorphisms in myelodysplastic syndrome.
|
26482462 |
2016 |
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
No significant association was observed between the variant alleles of hOGG1-Ser326Cys (OR=1.32, 95% CI=0.83-2.11), APE1-Asp148Glu (OR=1.08, 95% CI=0.70-1.68), XRCC1-Arg280His (OR=0.53, 95% CI=0.24-1.14) and XRCC1-Arg399Gln (OR=1.05, 95% CI=0.68-1.63) and AD.
|
18672023 |
2008 |
|
Amyotrophic Lateral Sclerosis, Sporadic
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of the present study was to investigate the possible contribution of three common functional polymorphisms in the DNA repair protein X-ray repair cross-complementing group 1 (XRCC1), namely Arg194Trp (rs1799782), Arg280His (rs25489) and Arg399Gln (rs25487), to sporadic amyotrophic lateral sclerosis (SALS).
|
19707910 |
2010 |
|
Bladder Neoplasm
|
|
0.080 |
GeneticVariation
|
BEFREE |
Our meta-analysis shows that XRCC1 Arg194Trp and Arg280His polymorphisms are associated with a significantly increased risk of bladder cancer in Asian population.
|
23704969 |
2013 |
|
Bladder Neoplasm
|
|
0.080 |
GeneticVariation
|
BEFREE |
Our meta-analysis results suggest that XRCC1 Arg194Trp and Arg280His polymorphisms are associated with significantly increased risk of bladder cancer in Asians.
|
23636799 |
2013 |
|
Bladder Neoplasm
|
|
0.080 |
GeneticVariation
|
BEFREE |
We provide no evidence of an association between polymorphisms in XRCC1 and bladder cancer risk, although our study had only limited power to detect the association for low frequency variants, such as Arg280His.
|
17425776 |
2007 |
|
Bladder Neoplasm
|
|
0.080 |
GeneticVariation
|
BEFREE |
We found an increased risk of bladder cancer associated with the XRCC1 194Trp/Trp and 280Arg/His genotypes (adjusted odds ratio = 3.90, 95% confidence interval = 1.69-8.98 for 194Trp/Trp and 2.53, 1.67-3.83 for 280Arg/His) compared with the 194Arg/Arg and 280Arg/Arg genotypes, respectively.
|
20218899 |
2010 |
|
Bladder Neoplasm
|
|
0.080 |
GeneticVariation
|
BEFREE |
No association was found between the polymorphisms in XRCC1 (Arg(194)Trp, Arg(280)His, Arg(399)Gln) and bladder cancer susceptibility.
|
18336890 |
2008 |
|
Bladder Neoplasm
|
|
0.080 |
GeneticVariation
|
BEFREE |
However, the XRCC1 R194W and R280H polymorphisms were both associated with increased bladder cancer risk among Asians.
|
24039945 |
2013 |
|
Bladder Neoplasm
|
|
0.080 |
GeneticVariation
|
BEFREE |
This meta-analysis suggested that XRCC1 Arg194Trp and Arg280His polymorphisms were risk factors for increasing bladder cancer in Asian population.
|
24266849 |
2013 |
|
Bladder Neoplasm
|
|
0.080 |
GeneticVariation
|
BEFREE |
Moreover, in the subgroup analysis by cancer type, we found that XRCC1-rs25489 polymorphism was associated with an increased risk of bladder cancer (BC) in heterozygote model.
|
28330811 |
2017 |
|
Brain Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
We evaluated the association of SNPs Arg194Trp, Arg280His, and Arg399Gln in the X-ray cross-complementing group 1 (XRCC1) and Thr241Met in the X-ray cross-complementing group 3 (XRCC3) DNA repair genes with the risk of brain tumors.
|
18330515 |
2008 |
|
Breast Carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
The study goal was to examine the association of three polymorphisms in the XRCC1 gene (Arg194Trp, Arg280His, and Arg399Gln) involved in repairing DNA damage produced by ionizing radiation, a known breast cancer (BC) risk factor, with BC incidence and the possibility of developing an adverse radiotherapy response.
|
14652276 |
2003 |
|
Breast Carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
However, Arg194Trp (recessive model, OR = 0.95, 95% CI: 0.75-1.20) and Arg280His (recessive model, OR = 1.28, 95% CI: 0.64-2.55) did not appear to be risk factors for breast cancer.
|
19465687 |
2009 |
|
Breast Carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
An association was observed between p.Arg280His-rs25489 and breast cancer risk for BRCA2 mutation carriers, with rare homozygotes at increased risk relative to common homozygotes (hazard ratio: 22.3, 95% confidence interval: 14.3-34, P<0.001).
|
21427728 |
2011 |
|
Breast Carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
In this study, we evaluated if polymorphisms in DNA repair genes XRCC1 (Arg280His, Arg399Gln) and XPD (Lys751Gln) modify individual breast cancer risk, with emphasis on tobacco smoking.
|
16280050 |
2005 |
|
Breast Carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
Using data from U.S. study participants with mouthwash DNA, we found no significant overall association between breast cancer risk and XRCC1 R280H and R194W, ADPRT V726W, APEX1 D148E, OGG1 S326C, LIG3 R780H, or MUTYH 5' untranslated region.
|
16492928 |
2006 |
|
Breast Carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
PubMed, Medline, Web of Science, and PubMed Central were systematically searched to identify studies evaluating association between breast cancer and XRCC1 gene polymorphisms (Arg194Trp, Arg280His and Arg399Gln).
|
27165246 |
2016 |
|
Breast Carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
These findings suggest that polymorphisms Arg280His and Arg399Gln may modify breast cancer risk differently in Caucasian and Asian populations.
|
19446452 |
2009 |
|
Carcinoma of bladder
|
|
0.080 |
GeneticVariation
|
BEFREE |
This meta-analysis suggested that XRCC1 Arg194Trp and Arg280His polymorphisms were risk factors for increasing bladder cancer in Asian population.
|
24266849 |
2013 |
|
Carcinoma of bladder
|
|
0.080 |
GeneticVariation
|
BEFREE |
No association was found between the polymorphisms in XRCC1 (Arg(194)Trp, Arg(280)His, Arg(399)Gln) and bladder cancer susceptibility.
|
18336890 |
2008 |
|
Carcinoma of bladder
|
|
0.080 |
GeneticVariation
|
BEFREE |
Our meta-analysis shows that XRCC1 Arg194Trp and Arg280His polymorphisms are associated with a significantly increased risk of bladder cancer in Asian population.
|
23704969 |
2013 |
|
Carcinoma of bladder
|
|
0.080 |
GeneticVariation
|
BEFREE |
Our meta-analysis results suggest that XRCC1 Arg194Trp and Arg280His polymorphisms are associated with significantly increased risk of bladder cancer in Asians.
|
23636799 |
2013 |
|
Carcinoma of bladder
|
|
0.080 |
GeneticVariation
|
BEFREE |
Moreover, in the subgroup analysis by cancer type, we found that XRCC1-rs25489 polymorphism was associated with an increased risk of bladder cancer (BC) in heterozygote model.
|
28330811 |
2017 |
|
Carcinoma of bladder
|
|
0.080 |
GeneticVariation
|
BEFREE |
However, the XRCC1 R194W and R280H polymorphisms were both associated with increased bladder cancer risk among Asians.
|
24039945 |
2013 |