|
Osteosarcoma of bone
|
|
0.010 |
GeneticVariation
|
BEFREE |
Besides, no significant association of rs25487, rs1799782, and rs25489 with OS was observed.
|
30464596 |
2018 |
|
Central neuroblastoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Stratified analysis revealed that the <i>XRCC1</i> rs25489 CT/TT was strongly associated with reduced risk of neuroblastoma in the children ≤ 18 months of age and subgroup with clinical stage I+II+4s diseases, compared with CC genotypes.
|
30362960 |
2018 |
|
Childhood Osteosarcoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Besides, no significant association of rs25487, rs1799782, and rs25489 with OS was observed.
|
30464596 |
2018 |
|
Childhood Neuroblastoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Stratified analysis revealed that the <i>XRCC1</i> rs25489 CT/TT was strongly associated with reduced risk of neuroblastoma in the children ≤ 18 months of age and subgroup with clinical stage I+II+4s diseases, compared with CC genotypes.
|
30362960 |
2018 |
|
Osteosarcoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Besides, no significant association of rs25487, rs1799782, and rs25489 with OS was observed.
|
30464596 |
2018 |
|
Lupus Erythematosus, Systemic
|
|
0.010 |
GeneticVariation
|
BEFREE |
The present study suggests that the XRCC1 Arg399Gln polymorphism might be associated with genetic susceptibility to SLE in Asians and Caucasians, and there is no significant association between XRCC1 gene polymorphisms (Arg399Gln, Arg280His and Arg194Trp) and RA risk.
|
28198159 |
2018 |
|
Papillary thyroid carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
However There was no relation of rs25489 Rs25487 and rs13181 with PTC.
|
30165355 |
2018 |
|
Neuroblastoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Stratified analysis revealed that the <i>XRCC1</i> rs25489 CT/TT was strongly associated with reduced risk of neuroblastoma in the children ≤ 18 months of age and subgroup with clinical stage I+II+4s diseases, compared with CC genotypes.
|
30362960 |
2018 |
|
Malignant Childhood Neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
Results We demonstrated an association between six previously published single nucleotide polymorphisms (rs15869 [ BRCA2], rs1805389 [ LIG4], rs8079544 [ TP53], rs25489 [ XRCC1], rs1673041 [ POLD1], and rs11615 [ ERCC1]) and subsequent CNS tumors in survivors of childhood cancer.
|
28976792 |
2017 |
|
Urologic Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
To sum up, our results indicated that XRCC1-rs25489 polymorphism is a risk factor for urological neoplasms, particularly for BC.
|
28330811 |
2017 |
|
Skin carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of this study was to estimate the association between three coding polymorphisms (Arg399Gln, Arg194Trp, and Arg280His) of the DNA repair gene X-ray repair cross-complementing group 1 (XRCC1) and NMSC susceptibility.
|
28761356 |
2017 |
|
Central Nervous System Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
Results We demonstrated an association between six previously published single nucleotide polymorphisms (rs15869 [ BRCA2], rs1805389 [ LIG4], rs8079544 [ TP53], rs25489 [ XRCC1], rs1673041 [ POLD1], and rs11615 [ ERCC1]) and subsequent CNS tumors in survivors of childhood cancer.
|
28976792 |
2017 |
|
Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found that the wide genotype GG of X-ray repair cross-complementing 1 (<i>XRCC1</i>) rs25489 (GG vs GA: OR=3.833, 95%CI=1.512-9.714, <i>P</i>=0.005; GG vs GA+AA: OR=3.610, 95%CI=1.496-8.713, <i>P</i>=0.004) and the wide genotype CC of 8-oxoguanine DNA glycosylase (<i>OGG1</i>) rs1052133 (CC vs GG: OR=0.263, 95%CI=0.073-0.951, <i>P</i>=0.042; CC vs CG+GG: OR=0.454, 95%CI=0.195-1.053, <i>P</i>=0.066) were positively and negatively associated with primary tumor efficacy at the end of radiotherapy, respectively.
|
29108254 |
2017 |
|
Malignant neoplasm of larynx
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, the results of our study suggest that the AA genotype and A allele of the XRCC1 Arg280His polymorphism are associated with an increased laryngeal cancer risk in a Chinese population.
|
27808358 |
2016 |
|
Carcinoma of larynx
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, the results of our study suggest that the AA genotype and A allele of the XRCC1 Arg280His polymorphism are associated with an increased laryngeal cancer risk in a Chinese population.
|
27808358 |
2016 |
|
Adult Myelodysplastic Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association of XPD (Lys751Gln) and XRCC1 (Arg280His) gene polymorphisms in myelodysplastic syndrome.
|
26482462 |
2016 |
|
Childhood Myelodysplastic Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association of XPD (Lys751Gln) and XRCC1 (Arg280His) gene polymorphisms in myelodysplastic syndrome.
|
26482462 |
2016 |
|
MYELODYSPLASTIC SYNDROME
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our study suggests that XRCC1 (Arg280His) and XPD polymorphisms are associated with risk of MDS and XRCC1 polymorphism strongly associated with advanced MDS subgroup.
|
26482462 |
2016 |
|
Squamous cell carcinoma of oropharynx
|
|
0.010 |
GeneticVariation
|
BEFREE |
XRCC1 c.580CT or TT genotypes (19.5 vs. 11.0 %, P = 0.04) and XRCC1 TTGG haplotype from c.-77T>C, c.580C>T, c.839G>A and c.1196G>A SNPs (17.5 vs. 10.0 %, P = 0.04) were more common in patients with OPSCC than in controls.
|
27372710 |
2016 |
|
Myocardial Infarction
|
|
0.010 |
GeneticVariation
|
BEFREE |
For the other two NEIL3 SNPs (rs10013040 and rs1395479) and for the SNPs of OGG1 (rs1052133), APEX1 (rs1878703) and XRCC1 (rs25489) we observed no association with risk of myocardial infarction.
|
25703835 |
2015 |
|
Congenital chromosomal disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Cells expressing R280H showed significantly increased levels of chromosomal aberrations and accumulate double strand breaks in the G1 cell cycle phase.
|
26011397 |
2015 |
|
Lip and Oral Cavity Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The meta-analysis results suggest that the XRCC1 Arg399Gln and Arg280His polymorphisms are probably not associated with the risk of HNC, but the XRCC1 Arg194Trp polymorphism was associated with increased risk of HNC in the subgroup analysis of studies adjusted for smoking and alcohol and with increased risk of oral cancer in the stratified analyses based on cancer site.
|
24497981 |
2014 |
|
Hematologic Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
The current meta-analysis indicated that the Arg280His polymorphism in the XRCC1 gene might not be a risk factor for hematological malignancies.
|
24096581 |
2014 |
|
Leukemia, Myelocytic, Acute
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our study aimed to evaluate the relationship between XRCC1 Arg194Trp, Arg280His and Arg399Gln polymorphisms and AML.
|
23662987 |
2014 |
|
Malignant neoplasm of mouth
|
|
0.010 |
GeneticVariation
|
BEFREE |
The meta-analysis results suggest that the XRCC1 Arg399Gln and Arg280His polymorphisms are probably not associated with the risk of HNC, but the XRCC1 Arg194Trp polymorphism was associated with increased risk of HNC in the subgroup analysis of studies adjusted for smoking and alcohol and with increased risk of oral cancer in the stratified analyses based on cancer site.
|
24497981 |
2014 |