Lymphoma
|
|
0.720 |
GeneticVariation
|
BEFREE |
These results suggest that Ezh2(Y641F) induces lymphoma and melanoma through a vast reorganization of chromatin structure, inducing both repression and activation of polycomb-regulated loci.
|
27135738 |
2016 |
Lymphoma
|
|
0.720 |
GeneticVariation
|
CLINVAR |
Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma.
|
24563539 |
2014 |
Lymphoma
|
|
0.720 |
GeneticVariation
|
BEFREE |
As EZH2 mutations often coincide with other mutations in lymphoma, we combined the expression of EZH2(Y641F) by crossing these transgenic mice with Eµ-Myc transgenic mice.
|
24802772 |
2014 |
Lymphoma
|
|
0.720 |
GeneticVariation
|
CLINVAR |
A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells.
|
23023262 |
2012 |
Lymphoma
|
|
0.720 |
GeneticVariation
|
CLINVAR |
A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells.
|
23023262 |
2012 |
Lymphoma, Non-Hodgkin, Familial
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
Cutaneous Melanoma
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
Cutaneous Melanoma
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
Lymphoma, Non-Hodgkin, Familial
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
Adult Lymphoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
These results suggest that Ezh2(Y641F) induces lymphoma and melanoma through a vast reorganization of chromatin structure, inducing both repression and activation of polycomb-regulated loci.
|
27135738 |
2016 |
Childhood Lymphoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
These results suggest that Ezh2(Y641F) induces lymphoma and melanoma through a vast reorganization of chromatin structure, inducing both repression and activation of polycomb-regulated loci.
|
27135738 |
2016 |
Childhood Lymphoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
As EZH2 mutations often coincide with other mutations in lymphoma, we combined the expression of EZH2(Y641F) by crossing these transgenic mice with Eµ-Myc transgenic mice.
|
24802772 |
2014 |
Adult Lymphoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
As EZH2 mutations often coincide with other mutations in lymphoma, we combined the expression of EZH2(Y641F) by crossing these transgenic mice with Eµ-Myc transgenic mice.
|
24802772 |
2014 |
melanoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
These results suggest that Ezh2(Y641F) induces lymphoma and melanoma through a vast reorganization of chromatin structure, inducing both repression and activation of polycomb-regulated loci.
|
27135738 |
2016 |
Leukemogenesis
|
|
0.010 |
GeneticVariation
|
BEFREE |
In summary, EZH2(Y641F) can collaborate with Myc to accelerate lymphomagenesis demonstrating a cooperative role of EZH2 mutations in oncogenesis.
|
24802772 |
2014 |
Carcinogenesis
|
|
0.010 |
GeneticVariation
|
BEFREE |
In summary, EZH2(Y641F) can collaborate with Myc to accelerate lymphomagenesis demonstrating a cooperative role of EZH2 mutations in oncogenesis.
|
24802772 |
2014 |