|
Pancreatic carcinoma
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
|
25086665 |
2014 |
|
Pancreatic carcinoma
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer.
|
29422604 |
2018 |
|
Prostate specific antigen measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Overall, we detected a genome-wide significant association between PSA levels and single-nucleotide polymorphisms (SNPs) at six loci: 5p15.33 (rs2736098), 10q11 (rs10993994), 10q26 (rs10788160), 12q24 (rs11067228), 17q12 (rs4430796), and 19q13.33 [rs17632542 (KLK3: I179T)], each with P(combined) <3 × 10(-10).
|
21160077 |
2010 |
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition, we found an increased risk of cancer in both rs2736098 and rs401681 homozygous variant genetic model.
|
23707794 |
2013 |
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our meta-analysis did not show that the TERT rs2736098 plays an important role in cancer risk.
|
23244087 |
2012 |
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
The A allele in the rs2736098 G > A polymorphism contributes to susceptibility in many types of cancer, especially lung cancer and bladder cancer.
|
29695979 |
2018 |
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
These findings provided further evidence that TERT rs2736098 variant may modify the susceptibility to cancer.
|
27273963 |
2016 |
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Additionally, rs2736098 (p-valuecor ≤ 0.0234) was associated with only sporadic cancers; also in group without carriers of high-risk mutation.
|
24171766 |
2013 |
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
Significant differences (Bonferroni corrected p-valuecor ≤ 0.0197) in the frequency of alleles distribution between all cancer and control subjects were observed for four (rs2736098, rs13281615, rs1219648, rs2981582) out of 16 SNPs.
|
24171766 |
2013 |
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our meta-analysis did not show that the TERT rs2736098 plays an important role in cancer risk.
|
23244087 |
2012 |
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition, we found an increased risk of cancer in both rs2736098 and rs401681 homozygous variant genetic model.
|
23707794 |
2013 |
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the meta-analysis, a borderline significant association between the rs2736098 polymorphism and overall cancer risk was observed (AA vs. GG: OR = 1.25, 95% CI = 1.07-1.46; AA vs. AG+GG: OR = 1.22, 95% CI = 1.06-1.41; additive model: OR = 1.10, 95% CI = 1.02-1.18), and further stratifications demonstrated a moderately increased risk for lung and bladder cancer, Asian ethnicity and hospital-based studies.
|
24260099 |
2013 |
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
The A allele in the rs2736098 G > A polymorphism contributes to susceptibility in many types of cancer, especially lung cancer and bladder cancer.
|
29695979 |
2018 |
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
<i>TERT</i> rs2736098 (Ex2-659G>A) polymorphism and cancer susceptibility: evidence from a comprehensive meta-analysis.
|
29221218 |
2017 |
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
Single-nucleotide polymorphisms (SNPs) of TERT-rs2736098 (C > T) and CLPTM1L-rs401681(C > T) at the 5p15.33 locus are significantly associated with cancer risk as reported in genome-wide association studies (GWAS), but there are no reported studies for squamous cell carcinoma of the head and neck (SCCHN).
|
20802237 |
2010 |
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition, single nucleotide polymorphisms (SNPs) in the TERT rs2736098 and rs2736100 are significantly associated with cancer susceptibility.
|
28416747 |
2017 |
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition, single nucleotide polymorphisms (SNPs) in the TERT rs2736098 and rs2736100 are significantly associated with cancer susceptibility.
|
28416747 |
2017 |
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
These findings provided further evidence that TERT rs2736098 variant may modify the susceptibility to cancer.
|
27273963 |
2016 |
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
<i>TERT</i> rs2736098 (Ex2-659G>A) polymorphism and cancer susceptibility: evidence from a comprehensive meta-analysis.
|
29221218 |
2017 |
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
Overall, this meta-analysis indicates that the TERT rs2736098 polymorphism may have little involvement in cancer susceptibility.
|
22994782 |
2012 |
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Single-nucleotide polymorphisms (SNPs) of TERT-rs2736098 (C > T) and CLPTM1L-rs401681(C > T) at the 5p15.33 locus are significantly associated with cancer risk as reported in genome-wide association studies (GWAS), but there are no reported studies for squamous cell carcinoma of the head and neck (SCCHN).
|
20802237 |
2010 |
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the meta-analysis, a borderline significant association between the rs2736098 polymorphism and overall cancer risk was observed (AA vs. GG: OR = 1.25, 95% CI = 1.07-1.46; AA vs. AG+GG: OR = 1.22, 95% CI = 1.06-1.41; additive model: OR = 1.10, 95% CI = 1.02-1.18), and further stratifications demonstrated a moderately increased risk for lung and bladder cancer, Asian ethnicity and hospital-based studies.
|
24260099 |
2013 |
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Overall, this meta-analysis indicates that the TERT rs2736098 polymorphism may have little involvement in cancer susceptibility.
|
22994782 |
2012 |
|
Carcinoma of lung
|
|
0.090 |
GeneticVariation
|
BEFREE |
The TERT rs2735940 g.C > T and rs2736098 g.G > A, and TNKS1 rs6985140 g.A > G were significantly associated with the risk of lung cancer.
|
19773453 |
2009 |
|
Malignant neoplasm of lung
|
|
0.090 |
GeneticVariation
|
BEFREE |
Twenty-two variants from 21 genes (APEX1 rs1130409 and rs1760944, ATM rs664677, AXIN2 rs2240308, CHRNA3 rs6495309, CHRNA5 rs16969968, CLPTM1L rs402710, CXCR2 rs1126579, CYP1A1 rs4646903, CYP2E1 rs6413432, ERCC1 rs11615, ERCC2 rs13181, FGFR4 rs351855, HYKK rs931794, MIR146A rs2910164, MIR196A2 rs11614913, OGG1 rs1052133, PON1 rs662, REV3L rs462779, SOD2 rs4880, TERT rs2736098, and TP53 rs1042522) showed significant associations with lung cancer susceptibility with strong cumulative epidemiological evidence.
|
28827732 |
2017 |