Pancreatic carcinoma
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer.
|
29422604 |
2018 |
Pancreatic carcinoma
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
|
25086665 |
2014 |
Prostate specific antigen measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Overall, we detected a genome-wide significant association between PSA levels and single-nucleotide polymorphisms (SNPs) at six loci: 5p15.33 (rs2736098), 10q11 (rs10993994), 10q26 (rs10788160), 12q24 (rs11067228), 17q12 (rs4430796), and 19q13.33 [rs17632542 (KLK3: I179T)], each with P(combined) <3 × 10(-10).
|
21160077 |
2010 |
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
The A allele in the rs2736098 G > A polymorphism contributes to susceptibility in many types of cancer, especially lung cancer and bladder cancer.
|
29695979 |
2018 |
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
The A allele in the rs2736098 G > A polymorphism contributes to susceptibility in many types of cancer, especially lung cancer and bladder cancer.
|
29695979 |
2018 |
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
<i>TERT</i> rs2736098 (Ex2-659G>A) polymorphism and cancer susceptibility: evidence from a comprehensive meta-analysis.
|
29221218 |
2017 |
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition, single nucleotide polymorphisms (SNPs) in the TERT rs2736098 and rs2736100 are significantly associated with cancer susceptibility.
|
28416747 |
2017 |
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition, single nucleotide polymorphisms (SNPs) in the TERT rs2736098 and rs2736100 are significantly associated with cancer susceptibility.
|
28416747 |
2017 |
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
<i>TERT</i> rs2736098 (Ex2-659G>A) polymorphism and cancer susceptibility: evidence from a comprehensive meta-analysis.
|
29221218 |
2017 |
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
These findings provided further evidence that TERT rs2736098 variant may modify the susceptibility to cancer.
|
27273963 |
2016 |
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
These findings provided further evidence that TERT rs2736098 variant may modify the susceptibility to cancer.
|
27273963 |
2016 |
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition, we found an increased risk of cancer in both rs2736098 and rs401681 homozygous variant genetic model.
|
23707794 |
2013 |
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Additionally, rs2736098 (p-valuecor ≤ 0.0234) was associated with only sporadic cancers; also in group without carriers of high-risk mutation.
|
24171766 |
2013 |
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
Significant differences (Bonferroni corrected p-valuecor ≤ 0.0197) in the frequency of alleles distribution between all cancer and control subjects were observed for four (rs2736098, rs13281615, rs1219648, rs2981582) out of 16 SNPs.
|
24171766 |
2013 |
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition, we found an increased risk of cancer in both rs2736098 and rs401681 homozygous variant genetic model.
|
23707794 |
2013 |
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the meta-analysis, a borderline significant association between the rs2736098 polymorphism and overall cancer risk was observed (AA vs. GG: OR = 1.25, 95% CI = 1.07-1.46; AA vs. AG+GG: OR = 1.22, 95% CI = 1.06-1.41; additive model: OR = 1.10, 95% CI = 1.02-1.18), and further stratifications demonstrated a moderately increased risk for lung and bladder cancer, Asian ethnicity and hospital-based studies.
|
24260099 |
2013 |
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the meta-analysis, a borderline significant association between the rs2736098 polymorphism and overall cancer risk was observed (AA vs. GG: OR = 1.25, 95% CI = 1.07-1.46; AA vs. AG+GG: OR = 1.22, 95% CI = 1.06-1.41; additive model: OR = 1.10, 95% CI = 1.02-1.18), and further stratifications demonstrated a moderately increased risk for lung and bladder cancer, Asian ethnicity and hospital-based studies.
|
24260099 |
2013 |
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our meta-analysis did not show that the TERT rs2736098 plays an important role in cancer risk.
|
23244087 |
2012 |
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our meta-analysis did not show that the TERT rs2736098 plays an important role in cancer risk.
|
23244087 |
2012 |
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
Overall, this meta-analysis indicates that the TERT rs2736098 polymorphism may have little involvement in cancer susceptibility.
|
22994782 |
2012 |
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Overall, this meta-analysis indicates that the TERT rs2736098 polymorphism may have little involvement in cancer susceptibility.
|
22994782 |
2012 |
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
Single-nucleotide polymorphisms (SNPs) of TERT-rs2736098 (C > T) and CLPTM1L-rs401681(C > T) at the 5p15.33 locus are significantly associated with cancer risk as reported in genome-wide association studies (GWAS), but there are no reported studies for squamous cell carcinoma of the head and neck (SCCHN).
|
20802237 |
2010 |
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Single-nucleotide polymorphisms (SNPs) of TERT-rs2736098 (C > T) and CLPTM1L-rs401681(C > T) at the 5p15.33 locus are significantly associated with cancer risk as reported in genome-wide association studies (GWAS), but there are no reported studies for squamous cell carcinoma of the head and neck (SCCHN).
|
20802237 |
2010 |
Carcinoma of lung
|
|
0.090 |
GeneticVariation
|
BEFREE |
In the subgroup analysis based on cancer type, the TERT rs2736098 with the A allele was 1.299 times more frequent than that with the G allele (OR = 1.299, 95% CI = 1.216-1.386) under the allelic genetic model in lung cancer, and 1.152 times (OR = 1.152, 95% CI = 1.032-1.286) that in bladder cancer.
|
29695979 |
2018 |
Malignant neoplasm of lung
|
|
0.090 |
GeneticVariation
|
BEFREE |
In the subgroup analysis based on cancer type, the TERT rs2736098 with the A allele was 1.299 times more frequent than that with the G allele (OR = 1.299, 95% CI = 1.216-1.386) under the allelic genetic model in lung cancer, and 1.152 times (OR = 1.152, 95% CI = 1.032-1.286) that in bladder cancer.
|
29695979 |
2018 |