The meta-analysis included 58 eligible studies demonstrated that harboring <i>XPA</i> rs10817938, <i>XPD</i> rs238406 increased overall cancer risk, however, <i>XPA</i> rs2808668 SNP in overall cancer analysis and <i>XPF</i> rs3136038 in the digestive system remarkably reduced the cancer risk.
The meta-analysis included 58 eligible studies demonstrated that harboring <i>XPA</i> rs10817938, <i>XPD</i> rs238406 increased overall cancer risk, however, <i>XPA</i> rs2808668 SNP in overall cancer analysis and <i>XPF</i> rs3136038 in the digestive system remarkably reduced the cancer risk.
XPA rs2808668 and drinking, DDB2 rs326222, rs3781619, rs830083 and smoking demonstrated significant interactions in AG; XPC rs2607775 had significant interaction with smoking in GC.
XPA rs2808668 and drinking, DDB2 rs326222, rs3781619, rs830083 and smoking demonstrated significant interactions in AG; XPC rs2607775 had significant interaction with smoking in GC.
Moreover, the T-G (including rs2808668 and rs1800975) haplotype in XPA combined with the ERCC2 T allele in rs50872 carriers was also associated with additive risk effect of BC (odds ratios: 2.58, 2.62, and 3.49, respectively).
Moreover, the T-G (including rs2808668 and rs1800975) haplotype in XPA combined with the ERCC2 T allele in rs50872 carriers was also associated with additive risk effect of BC (odds ratios: 2.58, 2.62, and 3.49, respectively).