|
Malignant neoplasm of breast
|
|
0.710 |
GeneticVariation
|
CLINVAR |
Association of Breast and Ovarian Cancers With Predisposition Genes Identified by Large-Scale Sequencing.
|
30128536 |
2019 |
|
Malignant neoplasm of breast
|
|
0.710 |
GeneticVariation
|
CLINVAR |
Pancreatic cancer as a sentinel for hereditary cancer predisposition.
|
29945567 |
2018 |
|
Malignant neoplasm of breast
|
|
0.710 |
GeneticVariation
|
CLINVAR |
Association Between Inherited Germline Mutations in Cancer Predisposition Genes and Risk of Pancreatic Cancer.
|
29922827 |
2018 |
|
Malignant neoplasm of breast
|
|
0.710 |
GeneticVariation
|
CLINVAR |
Novel genetic mutations detected by multigene panel are associated with hereditary colorectal cancer predisposition.
|
30256826 |
2018 |
|
Malignant neoplasm of breast
|
|
0.710 |
GeneticVariation
|
CLINVAR |
Assigning clinical meaning to somatic and germ-line whole-exome sequencing data in a prospective cancer precision medicine study.
|
28125075 |
2017 |
|
Malignant neoplasm of breast
|
|
0.710 |
GeneticVariation
|
CLINVAR |
Revisiting breast cancer patients who previously tested negative for BRCA mutations using a 12-gene panel.
|
27798748 |
2017 |
|
Malignant neoplasm of breast
|
|
0.710 |
GeneticVariation
|
CLINVAR |
Contribution of germline mutations in cancer predisposition genes to tumor etiology in young women diagnosed with invasive breast cancer.
|
28503720 |
2017 |
|
Malignant neoplasm of breast
|
|
0.710 |
GeneticVariation
|
CLINVAR |
Pathogenic and likely pathogenic variant prevalence among the first 10,000 patients referred for next-generation cancer panel testing.
|
26681312 |
2016 |
|
Malignant neoplasm of breast
|
|
0.710 |
GeneticVariation
|
CLINVAR |
PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS.
|
27595995 |
2016 |
|
Malignant neoplasm of breast
|
|
0.710 |
GeneticVariation
|
CLINVAR |
Implementation of next-generation sequencing for molecular diagnosis of hereditary breast and ovarian cancer highlights its genetic heterogeneity.
|
27553368 |
2016 |
|
Malignant neoplasm of breast
|
|
0.710 |
GeneticVariation
|
CLINVAR |
Utilization of multigene panels in hereditary cancer predisposition testing: analysis of more than 2,000 patients.
|
24763289 |
2014 |
|
Malignant neoplasm of breast
|
|
0.710 |
GeneticVariation
|
CLINVAR |
Response to DNA damage of CHEK2 missense mutations in familial breast cancer.
|
22419737 |
2012 |
|
Malignant neoplasm of breast
|
|
0.710 |
GeneticVariation
|
CLINVAR |
Rare, evolutionarily unlikely missense substitutions in CHEK2 contribute to breast cancer susceptibility: results from a breast cancer family registry case-control mutation-screening study.
|
21244692 |
2011 |
|
Malignant neoplasm of breast
|
|
0.710 |
GeneticVariation
|
CLINVAR |
CHEK2 mutations affecting kinase activity together with mutations in TP53 indicate a functional pathway associated with resistance to epirubicin in primary breast cancer.
|
18725978 |
2008 |
|
Malignant neoplasm of breast
|
|
0.710 |
GeneticVariation
|
CLINVAR |
Rare germ line CHEK2 variants identified in breast cancer families encode proteins that show impaired activation.
|
16982735 |
2006 |
|
Malignant neoplasm of breast
|
|
0.710 |
GeneticVariation
|
CLINVAR |
Characterization of CHEK2 mutations in prostate cancer.
|
16835864 |
2006 |
|
Malignant neoplasm of breast
|
|
0.710 |
GeneticVariation
|
CLINVAR |
To evaluate the possible association of R117G and two germline variants reported elsewhere, R145W and I157T with breast cancer, we screened 737 BRCA1/2-negative familial breast cancer cases from 605 families, 459 BRCA1/2-positive cases from 335 families, and 723 controls from the United Kingdom, the Netherlands, and North America.
|
12610780 |
2003 |
|
Malignant neoplasm of breast
|
|
0.710 |
GeneticVariation
|
BEFREE |
To evaluate the possible association of R117G and two germline variants reported elsewhere, R145W and I157T with breast cancer, we screened 737 BRCA1/2-negative familial breast cancer cases from 605 families, 459 BRCA1/2-positive cases from 335 families, and 723 controls from the United Kingdom, the Netherlands, and North America.
|
12610780 |
2003 |
|
Malignant neoplasm of breast
|
|
0.710 |
GeneticVariation
|
CLINVAR |
CHEK2 variants in susceptibility to breast cancer and evidence of retention of the wild type allele in tumours.
|
12454775 |
2002 |
|
Neoplastic Syndromes, Hereditary
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Assigning clinical meaning to somatic and germ-line whole-exome sequencing data in a prospective cancer precision medicine study.
|
28125075 |
2017 |
|
Neoplastic Syndromes, Hereditary
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Revisiting breast cancer patients who previously tested negative for BRCA mutations using a 12-gene panel.
|
27798748 |
2017 |
|
Neoplastic Syndromes, Hereditary
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Implementation of next-generation sequencing for molecular diagnosis of hereditary breast and ovarian cancer highlights its genetic heterogeneity.
|
27553368 |
2016 |
|
Neoplastic Syndromes, Hereditary
|
|
0.700 |
GeneticVariation
|
CLINVAR |
PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS.
|
27595995 |
2016 |
|
Neoplastic Syndromes, Hereditary
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Pathogenic and likely pathogenic variant prevalence among the first 10,000 patients referred for next-generation cancer panel testing.
|
26681312 |
2016 |
|
Neoplastic Syndromes, Hereditary
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Rare, evolutionarily unlikely missense substitutions in CHEK2 contribute to breast cancer susceptibility: results from a breast cancer family registry case-control mutation-screening study.
|
21244692 |
2011 |