|
Liver carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Co-targeting p53-R249S and CDK4 synergistically suppresses survival of hepatocellular carcinoma cells.
|
31747859 |
2020 |
|
Liver carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
This review will discuss these findings as well as their clinical significance and implications for the development of a strategy to target multiple molecules as a therapy for p53-R249S-harboring HCC.
|
30608603 |
2019 |
|
Liver carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Droplet digital PCR detects high rate of TP53 R249S mutants in cell-free DNA of middle African patients with hepatocellular carcinoma.
|
29749584 |
2018 |
|
Liver carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
We discovered that the TP53 R249S mutation occurred in 7.7% of the HCC patients, and it was significantly associated with poor diagnosis.
|
28412734 |
2017 |
|
Liver carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Here we report a unique mechanism underlying the GOF of p53-R249S (p53-RS), a p53 mutant frequently detected in human hepatocellular carcinoma (HCC) that is highly related to hepatitis B infection and aflatoxin B1.
|
29225033 |
2017 |
|
Liver carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Furthermore, TP53 mutations were associated with shorter survival only in HBV-related HCC (p=0.02) whereas R249S mutations were identified exclusively in migrants.
|
25021421 |
2015 |
|
Liver carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Thus, R249S may specifically cooperate with HBX in a pathway to HCC</span> that bypasses cirrhosis.
|
23200676 |
2013 |
|
Liver carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Our study shows moderate prevalence of aflatoxin B1-related p53 mutation (R249S) in HCC with or without HBsAg.
|
24460352 |
2013 |
|
Liver carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
We have analyzed the associations between 19 SNPs spanning the TP53 locus and a single specific aflatoxin-induced TP53 mutation (R249S) in 85 in hepatocellular carcinoma cases and 132 controls from Thailand.
|
23836507 |
2013 |
|
Liver carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
R249S mutation was detected in 6.2% and 3.4% of the HCC and non-HCC groups, respectively, which was not significantly different.
|
23886144 |
2013 |
|
Liver carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Overall, these results support the preferential occurrence of R249S-mutated DNA in HCC developing in the absence of cirrhosis in a context of HBV chronic infection.
|
22675488 |
2012 |
|
Liver carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
These findings suggest that in HCC from The Gambia, complete HBX sequences are often associated with the presence of TP53 R249S mutation.
|
22759751 |
2012 |
|
Liver carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
TP53 mutations, particularly the hot spot mutations R249S and V157F, are associated with poor prognosis for patients with HCC.
|
21616106 |
2011 |
|
Liver carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
TP53 mutations, particularly the hot spot mutations R249S and V157F, are associated with poor prognosis for patients with HCC.
|
21094160 |
2011 |
|
Liver carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
HCC often harbors a TP53 (tumor protein p53) mutation at codon 249 (R249S).
|
21768053 |
2011 |
|
Liver carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
We suggest that p.R249S may contribute to hepatocarcinogenesis through interaction with HBx, conferring a subtle growth advantage at early steps of the transformation process, but that this interaction is not required for progression to advanced HCC.
|
20538734 |
2010 |
|
Liver carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Here, we summarize the mechanisms of R249S formation and the possible role of p.R249S protein in HCC pathogenesis.
|
19376640 |
2009 |
|
Liver carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Overall, these results suggest that HCC containing R249S can occur in the absence of significant recent exposure to aflatoxins.
|
19366907 |
2009 |
|
Liver carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The presence of the R249S mutation in exon 7 may indicate that these subjects with HCC have been exposed to aflatoxin (AFB1), and further investigation is in progress to measure AFB1-albumin adducts in the sera of these subjects.
|
16078640 |
2005 |
|
Liver carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
A selective mutation in TP53 (AGG-->AGT at codon 249, Arg-->Ser) has been identified as a hotspot in HCCs from such areas, reflecting DNA damage caused by aflatoxin metabolites.
|
15095302 |
2004 |
|
Liver carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
A mutation in the tumor suppressor p53 gene resulting in an Arg-->Ser substitution in position 249 is found frequently in human hepatocellular carcinomas associated with hepatitis B infection and with aflatoxin exposure.
|
7605578 |
1995 |
|
Liver carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
We report here that p53-deficient hepatoma cells (Hep3B) transfected with mutant p53-249ser (codon 249 Arg-->Ser) acquire a new phenotype with an increased in vitro survival and mitotic activity.
|
8174105 |
1994 |
|
Liver carcinoma
|
|
0.800 |
CausalMutation
|
CLINVAR |
|
|
|
|
Li-Fraumeni Syndrome
|
|
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
ovarian neoplasm
|
|
0.700 |
GeneticVariation
|
CLINVAR |
|
|
|