Our data provide the first evidence that the miR-146a rs2910164 polymorphism is associated with increased risk of CAD in Chinese Han population, which may be through influencing the expression levels of the miRNA.
The current meta-analysis results showed that rs2910164 CC genotype has a decreased risk with overall cardiovascular diseases and the specific coronary artery disease.
In conclusion, the current meta-analysis suggests lower risks of CAD for GG, GG + GC genotype and G allele of rs2910164, while rs2910164 is not associated with the risk of IS.
Our data provide the first evidence for the association of miR-146a rs2910164 and TCF21 rs12190287 with CAD in an Iranian population, encouraging further research to elucidate the disease-related effects of miR-146a rs2910164.
In the subgroup analysis by race, miR-146a rs2910164 polymorphism was significantly associated with an increased C</span>AD risk in Asians (OR = 1.18; 95% CI 1.04 - 1.33; P = 0.008).