In conclusion, the current meta-analysis suggests lower risks of CAD for GG, GG + GC genotype and G allele of rs2910164, while rs2910164 is not associated with the risk of IS.
Our data provide the first evidence that the miR-146a rs2910164 polymorphism is associated with increased risk of CAD in Chinese Han population, which may be through influencing the expression levels of the miRNA.
In the subgroup analysis by race, miR-146a rs2910164 polymorphism was significantly associated with an increased C</span>AD risk in Asians (OR = 1.18; 95% CI 1.04 - 1.33; P = 0.008).
The current meta-analysis results showed that rs2910164 CC genotype has a decreased risk with overall cardiovascular diseases and the specific coronary artery disease.
Our data provide the first evidence for the association of miR-146a rs2910164 and TCF21 rs12190287 with CAD in an Iranian population, encouraging further research to elucidate the disease-related effects of miR-146a rs2910164.