|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
P21 Ser31Arg and FGFR2 rs2981582 Polymorphisms as Risk Factors for Early Onset of Breast Cancer in Yogyakarta, Indonesia.
|
31759353 |
2019 |
|
Malignant neoplasm of breast
|
|
0.800 |
GeneticVariation
|
BEFREE |
P21 Ser31Arg and FGFR2 rs2981582 Polymorphisms as Risk Factors for Early Onset of Breast Cancer in Yogyakarta, Indonesia.
|
31759353 |
2019 |
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The association of the fibroblast growth factor receptor 2 gene (<i>FGFR2</i>) polymorphism rs2981582 with breast cancer has been extensively studied, whereas the role of this polymorphism in non-functioning pituitary adenoma (NFPA) has not been elucidated.
|
30206133 |
2018 |
|
Malignant neoplasm of breast
|
|
0.800 |
GeneticVariation
|
BEFREE |
The association of the fibroblast growth factor receptor 2 gene (<i>FGFR2</i>) polymorphism rs2981582 with breast cancer has been extensively studied, whereas the role of this polymorphism in non-functioning pituitary adenoma (NFPA) has not been elucidated.
|
30206133 |
2018 |
|
Malignant neoplasm of breast
|
|
0.800 |
GeneticVariation
|
BEFREE |
BC patients (n = 1687) randomly sampled in an adjuvant, randomized phase III trial (SUCCESS A study) were genotyped for nine BC risk SNPs: rs17468277 <i>(CASP8)</i> , rs2981582 <i>(FGFR2)</i> , rs13281615(8q24), rs3817198 <i>(LSP1)</i> , rs889312 <i>(MAP3K1)</i> , rs3803662 <i>(TOX3)</i> , rs13387042(2q35), rs4973768 <i>(SLC4A7)</i> , rs6504950 <i>(COX11)</i> .
|
28757652 |
2017 |
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
This meta-analysis of case-control studies provides strong evidence that FGFR2 (rs2981582, rs2420946 and rs2981578) polymorphisms were significantly associated with the BC risk.
|
27966449 |
2017 |
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
BC patients (n = 1687) randomly sampled in an adjuvant, randomized phase III trial (SUCCESS A study) were genotyped for nine BC risk SNPs: rs17468277 <i>(CASP8)</i> , rs2981582 <i>(FGFR2)</i> , rs13281615(8q24), rs3817198 <i>(LSP1)</i> , rs889312 <i>(MAP3K1)</i> , rs3803662 <i>(TOX3)</i> , rs13387042(2q35), rs4973768 <i>(SLC4A7)</i> , rs6504950 <i>(COX11)</i> .
|
28757652 |
2017 |
|
Malignant neoplasm of breast
|
|
0.800 |
GeneticVariation
|
BEFREE |
This study aims to determine the association between FGF10 (rs4415084 C>T), FGFR2 (rs2981582 C>T) and MAP3K1 (rs889312 A>C) gene polymorphisms and breast cancer, to analyse the discriminative ability of each SNP and to test the accuracy of the predictive breast cancer risk model which includes all SNPs.
|
29372690 |
2017 |
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
This study aims to determine the association between FGF10 (rs4415084 C>T), FGFR2 (rs2981582 C>T) and MAP3K1 (rs889312 A>C) gene polymorphisms and breast cancer, to analyse the discriminative ability of each SNP and to test the accuracy of the predictive breast cancer risk model which includes all SNPs.
|
29372690 |
2017 |
|
Malignant neoplasm of breast
|
|
0.800 |
GeneticVariation
|
BEFREE |
This meta-analysis of case-control studies provides strong evidence that FGFR2 (rs2981582, rs2420946 and rs2981578) polymorphisms were significantly associated with the BC risk.
|
27966449 |
2017 |
|
Malignant neoplasm of breast
|
|
0.800 |
GeneticVariation
|
BEFREE |
Furthermore, there was an increased effect of BC risk between haplotype combinations of the two SNPs of FGFR2 (rs2981582 and rs1219648) in Pakistani women.
|
27572905 |
2016 |
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genome-wide association study in East Asians identifies two novel breast cancer susceptibility loci.
|
27354352 |
2016 |
|
Malignant neoplasm of breast
|
|
0.800 |
GeneticVariation
|
BEFREE |
The genotype of rs2046210 (6q25.1), rs2981582 (EGFR2), rs889312 (MAP3K1), and rs3803662 (TOX3/TNRC9) has no statistical differences in different subtypes of breast cancer.
|
26803517 |
2016 |
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The genotype of rs2046210 (6q25.1), rs2981582 (EGFR2), rs889312 (MAP3K1), and rs3803662 (TOX3/TNRC9) has no statistical differences in different subtypes of breast cancer.
|
26803517 |
2016 |
|
Malignant neoplasm of breast
|
|
0.800 |
GeneticVariation
|
BEFREE |
Our findings indicate that the GG genotype of rs12443621 is associated with increased breast cancer risk whereas the GA and AA genotypes of rs2981582 are reduced risk in Han Chinese population.
|
26911390 |
2016 |
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Furthermore, there was an increased effect of BC risk between haplotype combinations of the two SNPs of FGFR2 (rs2981582 and rs1219648) in Pakistani women.
|
27572905 |
2016 |
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Our findings indicate that the GG genotype of rs12443621 is associated with increased breast cancer risk whereas the GA and AA genotypes of rs2981582 are reduced risk in Han Chinese population.
|
26911390 |
2016 |
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Significant associations with breast cancer risk were observed for rs2420946, rs2981579, and rs2981582 with OR (95% CI) per risk allele of 1.19 (1.03-1.39), 1.24 (1.07-1.43), and 1.17 (1.01-1.36), respectively.
|
26421298 |
2015 |
|
Malignant neoplasm of breast
|
|
0.800 |
GeneticVariation
|
BEFREE |
Significant associations with breast cancer risk were observed for rs2420946, rs2981579, and rs2981582 with OR (95% CI) per risk allele of 1.19 (1.03-1.39), 1.24 (1.07-1.43), and 1.17 (1.01-1.36), respectively.
|
26421298 |
2015 |
|
Malignant neoplasm of breast
|
|
0.800 |
GeneticVariation
|
BEFREE |
Exercise activity and FGFR2 rs2981582 were confirmed to be associated with breast cancer risk, and were found to significantly interact (P for multiplicative and additive interactions = 0.045 and 0.021, respectively).
|
25270516 |
2014 |
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Exercise activity and FGFR2 rs2981582 were confirmed to be associated with breast cancer risk, and were found to significantly interact (P for multiplicative and additive interactions = 0.045 and 0.021, respectively).
|
25270516 |
2014 |
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
We investigated the associations between breast cancer risk and the polymorphisms of FGFR2 rs2981582, FGF1 rs250108, and RBFOX2 rs2051579 among 839 incident breast cancer cases and 863 age-matched controls in the Guangzhou Breast Cancer Study.
|
23143756 |
2013 |
|
Malignant neoplasm of breast
|
|
0.800 |
GeneticVariation
|
BEFREE |
To investigate this inconsistency, we performed a meta-analysis of 37 studies involving a total of 288,142 subjects for rs2981582, rs1219648, and rs2420946 polymorphism of the FGFR2 gene to evaluate the effect of FGFR2 on genetic susceptibility for BC.
|
23184080 |
2013 |
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
We confirmed associations between rs13387042 (2q35), rs4973768 (SLC4A7), rs10941679 (5p12), rs2981582 (FGFR2), rs3817198 (LSP1), rs3803662 (TOX3), and rs6504950 (STXBP4) with breast cancer.
|
23893088 |
2013 |
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
To investigate this inconsistency, we performed a meta-analysis of 37 studies involving a total of 288,142 subjects for rs2981582, rs1219648, and rs2420946 polymorphism of the FGFR2 gene to evaluate the effect of FGFR2 on genetic susceptibility for BC.
|
23184080 |
2013 |