|
Malignant neoplasm of breast
|
|
0.030 |
GeneticVariation
|
BEFREE |
Similarly, the SNP barcode of rs12812942-rs2228014-rs3025039 (CD4-CXCR4-VEGF) and rs12812942-rs3136685-rs2228014-rs1801157 (CD4- CCR7-CXCR4-CXCL12) with specific genotype patterns (AT-CC-CC and AT-AG-CC-GG) among three and four combinational SNPs were significantly low in breast cancer occurrence.
|
19196101 |
2009 |
|
Breast Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
The present study aimed to evaluate the impact of VEGFA gene polymorphisms rs699947, rs833061, rs1570360, rs2010963 and rs3025039 on breast cancer features and prognosis.
|
27195611 |
2016 |
|
Malignant neoplasm of mouth
|
|
0.030 |
GeneticVariation
|
BEFREE |
Many studies have examined the association between the VEGF +936C/T (rs833061) and +460C/T (rs3025039) gene polymorphisms and oral cancer risk in various populations, but their results have been inconsistent.
|
24057253 |
2013 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Published data on the association between polymorphisms of vascular endothelial growth factor (e.g., -2578C/A [rs699947], -460T/C [rs833061], +405C/G [rs2010963], and +936C/T [rs3025039]) and the risk of renal cell carcinoma are ambiguous and controversial.
|
23073296 |
2013 |
|
Lip and Oral Cavity Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
In this study, we examined whether individual polymorphisms within VEGF-A gene, rs699947 (-2578C/A), rs1570360 (-1154G/A), rs2010963 (-634G/C), rs3025039 (+936C/T) or their haplotypes are associated with an oral cancer risk and survival.
|
22818823 |
2012 |
|
Rheumatoid Arthritis
|
|
0.030 |
GeneticVariation
|
BEFREE |
PCR-RFLP assays were used to determine the genotypes of VEGFA single-nucleotide polymorphisms (SNP) including VEGFA-2578A/C (rs699947), -460C/T (rs833061), +405C/G (rs2010963), and +936C/T (rs3025039) in 418 subjects with RA.
|
21362767 |
2011 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our meta-analysis suggested that there may be a relationship between the VEGF rs2010963, rs3025039 and rs699947 polymorphisms and RCC susceptibility.
|
28562357 |
2017 |
|
Rheumatoid Arthritis
|
|
0.030 |
GeneticVariation
|
BEFREE |
There were increased genotype frequencies in GA of rs833070, GC of rs3025030, CT of rs3025039 and decreased genotype frequencies in GG of rs833070, GG of rs3025030, CC of rs3025039 in the patients with RA compared with the controls.
|
21245770 |
2011 |
|
Renal Cell Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
In the meanwhile, this study also demonstrated that the allele contrast model of rs3025039 polymorphism was likely to be associated with risk of RCC in the Asian population.
|
28356760 |
2017 |
|
Diabetic Retinopathy
|
|
0.030 |
GeneticVariation
|
BEFREE |
The T allele in rs3025039 and the C allele in rs833061 are associated with increased DR susceptibility.
|
27613596 |
2017 |
|
Coronary Artery Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
To identify the markers contributing to the genetic susceptibility to CAD, we examined the potential association between CAD and 10 single nucleotide polymorphisms (SNPs, rs699947, rs1570360, rs2010963, rs833068, rs3024997, rs3025000, rs3025010, rs3025020, rs3025030, rs3025039) of the VEGF gene using the MassARRAY system.
|
23545315 |
2013 |
|
Diabetic Retinopathy
|
|
0.030 |
GeneticVariation
|
BEFREE |
No evidence of association was observed between -2578 A/C (rs699947), +405C/G (rs2010963), +936C/T (rs3025039), and DR risk under stringent Bonferroni's correction.
|
24534217 |
2014 |
|
Breast Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Here, we selected four commonly studied polymorphisms in VEGF, rs3025039 (known as +936 C/T), rs1109324, rs154765 and rs833052, one polymorphism at the promoter of the VEGFR1 (-710 C/T) and another in the FGF2, rs1449683, gene to explore their association with BC susceptibility.
|
22315135 |
2012 |
|
Mucocutaneous Lymph Node Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
A significant association with KD susceptibility was observed with 5 SNPs in the ANGPT1 gene (most significantly associated SNP +265037 C>T; Pcombined=2.3×10(-7) ) and 2 SNPs in VEGFA (most significantly associated SNP rs3025039; Pcombined=2.5×10(-4) ).
|
21905000 |
2012 |
|
Hypertensive disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Genotype CT of rs3025039, TT of rs2305948, and AA of rs1873077 were associated with a reduced risk of CHD when smoking, alcohol intake and diabetes were considered, while homozygote GG of rs1570360 might elevate the susceptibility to CHD (all P < 0.05) for patients who were addicted to smoking or those with hypertension.
|
27175642 |
2016 |
|
Carcinoma of bladder
|
|
0.020 |
GeneticVariation
|
BEFREE |
The VEGF gene rs3025039C/T and rs833052C/A variants may contribute to the risk of developing BCa, especially in Asian descendants.
|
30609111 |
2019 |
|
Malignant neoplasm of prostate
|
|
0.020 |
GeneticVariation
|
BEFREE |
The aim of this study was to evaluate the association between selected polymorphisms of the vascular endothelial growth factor gene (rs699947, rs144854329, rs833061, rs2010963, rs3025039) and the risk of prostate cancer development and progression.
|
31177128 |
2019 |
|
Polycystic Ovary Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
This study evaluated the association of polymorphisms of VEGF (endothelial vascular growth factor) gene + 936C/T (rs3025039), 1154 G/A (rs 1570360) and -2578 C/A (rs 699947) in patients with polycystic ovary syndrome (PCOS) and to perform the haplotypes formed by the alleles in the Brazilian population.
|
31032699 |
2019 |
|
Non-Small Cell Lung Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
We genotyped three potentially functional VEGF single nucleotide polymorphisms (-460 T > C [rs833061], -634 G > C [rs2010963] and +936 C > T [rs3025039]) and estimated the associations of their genotypes and haplotypes with severe radiation pneumonitis (RP ≥grade 3) in 195 NSCLC patients.
|
22320189 |
2012 |
|
Non-Small Cell Lung Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
We genotyped three potentially functional VEGF variants [-460 T > C (rs833061), -634 G > C (rs2010963), and +936 C > T (rs3025039)] and estimated haplotypes in 124 Caucasian patients with LA-NSCLC treated with definitive radiotherapy.
|
20712888 |
2010 |
|
Bladder Neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our meta-analysis suggested that rs3025039 (C > T), rs833052 (C > A) and rs25648 (C > T) polymorphisms of VEGF gene increased susceptibility to BCa risk.
|
30849545 |
2019 |
|
Mucocutaneous Lymph Node Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
An association with susceptibility to KD was observed with 2 of the 6 single-nucleotide polymorphisms analyzed in VEGF: -2594 A>C (rs699947) and the 236 bp 3' of STP C>T (rs3025039).
|
16645995 |
2006 |
|
Prostate carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The aim of this study was to evaluate the association between selected polymorphisms of the vascular endothelial growth factor gene (rs699947, rs144854329, rs833061, rs2010963, rs3025039) and the risk of prostate cancer development and progression.
|
31177128 |
2019 |
|
Polycystic Ovary Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
VEGF levels in rs699947 (AA-major homozygous), rs3025039 (CC-major homozygous) and rs833061 (TT & CC-major & minor homozygous) genotypes were significantly higher in PCOS.
|
31385237 |
2019 |
|
Prostate carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
VEGF rs3025039 polymorphism was also not associated with risk of prostate cancer (T versus C, OR = 1.03, 95% CI 0.91-1.16, P = 0.66; TT versus CC, OR = 1.82 95% CI 0.16-20.53, P = 0.63; TT versus CC/CT, OR = 2.00, 95% CI 0.18-22.41, P = 0.57; TT/CT versus CC, OR = 0.72, 95% CI 0.38-1.36, P = 0.31).
|
24353087 |
2014 |