|
Endometriosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
The remaining five of the 28 polymorphisms were not associated with endometriosis: glutathione S-transferase theta 1 (GSTT1) null genotype, vascular endothelial growth factor alpha (VEGFA) rs699947, rs833061, rs2010963 and rs3025039.
|
31821471 |
2020 |
|
Coronary heart disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
Further subgroup analyses according to ethnicity of study participants and type of disease demonstrated that the rs833061 polymorphism was significantly correlated with the risk of CHD in Asians under additive genetic model, and the rs3025039 polymorphism was significantly correlated with the risk of Tetralogy of Fallot (TOF) in dominant, recessive and allele models.
|
30689460 |
2018 |
|
Coronary heart disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
Overall, our findings indicate that VEGF rs699947, rs1570360, and rs3025039 polymorphisms may affect CHD susceptibility.
|
30317903 |
2018 |
|
Coronary heart disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
A significant association between VEGFA rs3025039 C>T polymorphism and risk of CHD was also found.
|
28430629 |
2017 |
|
Coronary heart disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
Genotype CT of rs3025039, TT of rs2305948, and AA of rs1873077 were associated with a reduced risk of CHD when smoking, alcohol intake and diabetes were considered, while homozygote GG of rs1570360 might elevate the susceptibility to CHD (all P < 0.05) for patients who were addicted to smoking or those with hypertension.
|
27175642 |
2016 |
|
Endometriosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Results from the meta-analysis suggest that the rs3025039 (C>T) polymorphism of the VEGF gene increases the risk of endometriosis, but the rs699947 (A>C) and rs1570360 (G>A) polymorphisms might be protective factors for en</span>dometriosis.
|
23613250 |
2013 |
|
Endometriosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Published data on the association between the vascular endothelial growth factor (VEGF) gene -460C/T (rs833061), +405G/C (rs2010963), +936T/C (rs3025039) polymorphisms and endometriosis risk are inconclusive.
|
23061744 |
2012 |
|
Endometriosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
To further investigate the reported association between VEGF variants and endometriosis, we tested the four VEGF polymorphisms (-2578 A/C, rs699947; -460 T/C, rs833061; +405 G/C, rs2010963 and +936 C/T, rs3025039) in a large Australian sample of 958 familial endometriosis cases and 959 controls.
|
18650217 |
2008 |
|
Coronary Artery Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
In summary, we concluded that the VEGF gene polymorphisms rs699947, rs2010963, and rs3025039 are correlated with an elevated CAD risk.
|
29973139 |
2018 |
|
Renal Cell Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our meta-analysis suggested that there may be a relationship between the VEGF rs2010963, rs3025039 and rs699947 polymorphisms and RCC susceptibility.
|
28562357 |
2017 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
In the meanwhile, this study also demonstrated that the allele contrast model of rs3025039 polymorphism was likely to be associated with risk of RCC in the Asian population.
|
28356760 |
2017 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our meta-analysis suggested that there may be a relationship between the VEGF rs2010963, rs3025039 and rs699947 polymorphisms and RCC susceptibility.
|
28562357 |
2017 |
|
Renal Cell Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
In the meanwhile, this study also demonstrated that the allele contrast model of rs3025039 polymorphism was likely to be associated with risk of RCC in the Asian population.
|
28356760 |
2017 |
|
Diabetic Retinopathy
|
|
0.030 |
GeneticVariation
|
BEFREE |
The T allele in rs3025039 and the C allele in rs833061 are associated with increased DR susceptibility.
|
27613596 |
2017 |
|
Malignant neoplasm of breast
|
|
0.030 |
GeneticVariation
|
BEFREE |
The present study aimed to evaluate the impact of VEGFA gene polymorphisms rs699947, rs833061, rs1570360, rs2010963 and rs3025039 on breast cancer features and prognosis.
|
27195611 |
2016 |
|
Age related macular degeneration
|
|
0.030 |
GeneticVariation
|
BEFREE |
Significant associations with AMD risk were showed for rs833061, rs1413711, and rs3025039 polymorphisms but not for rs2010963.
|
27999450 |
2016 |
|
Breast Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
The present study aimed to evaluate the impact of VEGFA gene polymorphisms rs699947, rs833061, rs1570360, rs2010963 and rs3025039 on breast cancer features and prognosis.
|
27195611 |
2016 |
|
Diabetic Retinopathy
|
|
0.030 |
GeneticVariation
|
BEFREE |
A significant relationship between VEGF+936C/T (rs3025</span>039) polymorphism and DR was found in a recessive model (OR = 3.19, 95% CI = 1.20-8.41, and P(z) = 0.01) in Asian and overall populations, while a significant association was also found between -460T/C (rs833061) polymorphism and DR risk under a recessive model (OR = 2.12, 95% CI = 1.12-4.01, and P(z) = 0.02).CONCLUSIONS.
|
24868559 |
2014 |
|
Age related macular degeneration
|
|
0.030 |
GeneticVariation
|
BEFREE |
The meta-analysis results based on nine case-control studies with 2427 cases and 2037 controls showed that rs833061 had protective effects on AMD risk (TT vs. CT+CC: OR=0.58, 95% CI=0.41-0.81), whereas rs1413711 (TT vs. CT+CC: OR=1.46, 95% CI=1.10-1.93) and rs3025039 (TT vs. CC: OR=1.87, 95% CI=1.15-3.02; TT vs. CT+CC: OR=2.09, 95% CI=1.30-3.37) represented as risk factors for AMD.
|
24689893 |
2014 |
|
Diabetic Retinopathy
|
|
0.030 |
GeneticVariation
|
BEFREE |
No evidence of association was observed between -2578 A/C (rs699947), +405C/G (rs2010963), +936C/T (rs3025039), and DR risk under stringent Bonferroni's correction.
|
24534217 |
2014 |
|
Lip and Oral Cavity Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
The association between VEGF 936 C>T (rs3025039) gene polymorphisms and oral cancer (OC) risk is still contentious and ambiguous.
|
23586368 |
2013 |
|
Age related macular degeneration
|
|
0.030 |
GeneticVariation
|
BEFREE |
No association was observed between AMD risk and the variant genotypes of VEGF-A rs2010963 and rs3025039 polymorphisms in different genetic models.
|
23761723 |
2013 |
|
Malignant neoplasm of mouth
|
|
0.030 |
GeneticVariation
|
BEFREE |
The association between VEGF 936 C>T (rs3025039) gene polymorphisms and oral cancer (OC) risk is still contentious and ambiguous.
|
23586368 |
2013 |
|
Rheumatoid Arthritis
|
|
0.030 |
GeneticVariation
|
BEFREE |
VEGFA rs699947 C/A, rs2010963 G/C, and rs3025039 C/T polymorphisms were not associated with the risk of RA.
|
23848209 |
2013 |
|
Lip and Oral Cavity Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Many studies have examined the association between the VEGF +936C/T (rs833061) and +460C/T (rs3025039) gene polymorphisms and oral cancer risk in various populations, but their results have been inconsistent.
|
24057253 |
2013 |