|
Adenocarcinoma of lung (disorder)
|
|
0.810 |
GeneticVariation
|
BEFREE |
Gene variations rs2736100 and rs2853676 in TERT and rs401681 and rs31489 in CLPTM1L had significant direct associations on lung adenocarcinoma without indirect effects through nicotine dependence.
|
25233467 |
2014 |
|
Adenocarcinoma of lung (disorder)
|
|
0.810 |
GeneticVariation
|
GWASCAT |
A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma.
|
19836008 |
2009 |
|
Adenocarcinoma of lung (disorder)
|
|
0.810 |
GeneticVariation
|
GWASDB |
A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma.
|
19836008 |
2009 |
|
Malignant neoplasm of lung
|
|
0.750 |
GeneticVariation
|
BEFREE |
Overall, the findings from our replication study and meta-analysis demonstrated that CLPTM1L gene rs31489 is significantly associated with lung cancer.
|
25422207 |
2014 |
|
Malignant neoplasm of lung
|
|
0.750 |
GeneticVariation
|
BEFREE |
Overall, significantly elevated LC risk was associated with rs2736100, rs401681, rs402710, and rs31489 polymorphisms when all studies were pooled into the meta-analysis.
|
24615522 |
2014 |
|
Malignant neoplasm of lung
|
|
0.750 |
GeneticVariation
|
BEFREE |
In conclusion, this meta-analysis suggested that CLPTM1L rs31489 was a potential biomarker for lung cancer risk in Caucasians.
|
24535780 |
2014 |
|
Malignant neoplasm of lung
|
|
0.750 |
GeneticVariation
|
BEFREE |
The rs31489 variant on 5p15.33 is associated with bronchial obstruction, presence and severity of emphysema, and lung cancer.
|
21622582 |
2011 |
|
Malignant neoplasm of lung
|
|
0.750 |
GeneticVariation
|
BEFREE |
SNP rs31489 showed the strongest evidence of familial lung cancer association on 5p15.33 (P = 2 x 10(-4); odds ratio, 0.57; 95% confidence interval, 0.42-0.77), whereas rs3117582 showed a weak association on 6p21.33 (P = 0.09; odds ratio, 1.47; 95% confidence interval, 0.94-2.31).
|
20142248 |
2010 |
|
Malignant neoplasm of lung
|
|
0.750 |
GeneticVariation
|
GWASDB |
Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study.
|
19654303 |
2009 |
|
Malignant neoplasm of lung
|
|
0.750 |
GeneticVariation
|
GWASDB |
Lung cancer susceptibility locus at 5p15.33.
|
18978790 |
2008 |
|
Nasopharyngeal carcinoma
|
|
0.720 |
GeneticVariation
|
BEFREE |
In this study, in southern China, where NPC is endemic, a single nucleotide polymorphism (SNP) in the EBV-encoded <i>RPMS1</i> gene (locus 155391: G > A [G155391A]) and seven host SNPs (rs1412829, rs28421666, rs2860580, rs2894207, rs31489, rs6774494, and rs9510787) were confirmed to be significantly associated with NPC risk in 50 NPC cases versus 54 hospital-based controls with throat washing specimens and 1925 NPC cases versus 1947 hospital-based controls with buffy coat samples, respectively.
|
29221111 |
2017 |
|
Nasopharyngeal carcinoma
|
|
0.720 |
GeneticVariation
|
BEFREE |
Supporting our finding, rs31489 and other SNPs in this region have been reported to be associated with multiple cancer sites, candidate-based studies have reported associations between polymorphisms in this region and NPC, the TERT gene has been shown to be important for telomere maintenance and has been reported to be overexpressed in NPC, and an EBV protein expressed in NPC (LMP1) has been reported to modulate TERT expression/telomerase activity.
|
26545403 |
2016 |
|
Nasopharyngeal carcinoma
|
|
0.720 |
GeneticVariation
|
GWASDB |
A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.
|
20512145 |
2010 |
|
Nasopharyngeal Neoplasms
|
|
0.700 |
GeneticVariation
|
GWASCAT |
A GWAS Meta-analysis and Replication Study Identifies a Novel Locus within CLPTM1L/TERT Associated with Nasopharyngeal Carcinoma in Individuals of Chinese Ancestry.
|
26545403 |
2016 |
|
Malignant Testicular Germ Cell Tumor
|
|
0.700 |
GeneticVariation
|
GWASDB |
Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer.
|
20543847 |
2010 |
|
Primary malignant neoplasm of lung
|
|
0.050 |
GeneticVariation
|
BEFREE |
Overall, significantly elevated LC risk was associated with rs2736100, rs401681, rs402710, and rs31489 polymorphisms when all studies were pooled into the meta-analysis.
|
24615522 |
2014 |
|
Carcinoma of lung
|
|
0.050 |
GeneticVariation
|
BEFREE |
In conclusion, this meta-analysis suggested that CLPTM1L rs31489 was a potential biomarker for lung cancer risk in Caucasians.
|
24535780 |
2014 |
|
Primary malignant neoplasm of lung
|
|
0.050 |
GeneticVariation
|
BEFREE |
In conclusion, this meta-analysis suggested that CLPTM1L rs31489 was a potential biomarker for lung cancer risk in Caucasians.
|
24535780 |
2014 |
|
Primary malignant neoplasm of lung
|
|
0.050 |
GeneticVariation
|
BEFREE |
Overall, the findings from our replication study and meta-analysis demonstrated that CLPTM1L gene rs31489 is significantly associated with lung cancer.
|
25422207 |
2014 |
|
Carcinoma of lung
|
|
0.050 |
GeneticVariation
|
BEFREE |
Overall, the findings from our replication study and meta-analysis demonstrated that CLPTM1L gene rs31489 is significantly associated with lung cancer.
|
25422207 |
2014 |
|
Carcinoma of lung
|
|
0.050 |
GeneticVariation
|
BEFREE |
Overall, significantly elevated LC risk was associated with rs2736100, rs401681, rs402710, and rs31489 polymorphisms when all studies were pooled into the meta-analysis.
|
24615522 |
2014 |
|
Primary malignant neoplasm of lung
|
|
0.050 |
GeneticVariation
|
BEFREE |
The rs31489 variant on 5p15.33 is associated with bronchial obstruction, presence and severity of emphysema, and lung cancer.
|
21622582 |
2011 |
|
Carcinoma of lung
|
|
0.050 |
GeneticVariation
|
BEFREE |
The rs31489 variant on 5p15.33 is associated with bronchial obstruction, presence and severity of emphysema, and lung cancer.
|
21622582 |
2011 |
|
Primary malignant neoplasm of lung
|
|
0.050 |
GeneticVariation
|
BEFREE |
SNP rs31489 showed the strongest evidence of familial lung cancer association on 5p15.33 (P = 2 x 10(-4); odds ratio, 0.57; 95% confidence interval, 0.42-0.77), whereas rs3117582 showed a weak association on 6p21.33 (P = 0.09; odds ratio, 1.47; 95% confidence interval, 0.94-2.31).
|
20142248 |
2010 |
|
Carcinoma of lung
|
|
0.050 |
GeneticVariation
|
BEFREE |
SNP rs31489 showed the strongest evidence of familial lung cancer association on 5p15.33 (P = 2 x 10(-4); odds ratio, 0.57; 95% confidence interval, 0.42-0.77), whereas rs3117582 showed a weak association on 6p21.33 (P = 0.09; odds ratio, 1.47; 95% confidence interval, 0.94-2.31).
|
20142248 |
2010 |