|
High density lipoprotein measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.
|
30275531 |
2018 |
|
Triglycerides measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.
|
30275531 |
2018 |
|
Frontotemporal dementia
|
|
0.030 |
GeneticVariation
|
BEFREE |
Recent studies found that two polymorphisms (rs363371 and rs363324) in VMAT2 might be a risk factor for Parkinson's disease (PD) in Caucasians, while the two other variants (rs1990622 and rs3173615) in TMEM106B increased the risk for frontotemporal dementia (FTD).
|
28477711 |
2017 |
|
Frontotemporal dementia
|
|
0.030 |
GeneticVariation
|
BEFREE |
The major allele of SNP rs3173615 is a risk factor in sporadic FTD, whereas the minor allele seems protective in GRN- and C9orf72-mediated FTD.
|
28888721 |
2017 |
|
Frontotemporal dementia
|
|
0.030 |
GeneticVariation
|
BEFREE |
TMEM106B p.T185S regulates TMEM106B protein levels: implications for frontotemporal dementia.
|
23742080 |
2013 |
|
DIARRHEA 5, WITH TUFTING ENTEROPATHY, CONGENITAL
|
|
0.020 |
GeneticVariation
|
BEFREE |
Eighty-six deceased male athletes with a history of participation in American football, informant-reported Caucasian, and a positive postmortem diagnosis of CTE without comorbid neurodegenerative disease were genotyped for rs3173615.
|
30390709 |
2018 |
|
DIARRHEA 5, WITH TUFTING ENTEROPATHY, CONGENITAL
|
|
0.020 |
GeneticVariation
|
BEFREE |
There were no significant differences in genetic variants for those with CTE pathology, but we observed a slight increase in MAPT H1 haplotype, and there tended to be fewer homozygous carriers of the protective TMEM106B rs3173615 minor allele in those with sports exposure and CTE pathology compared to those without CTE pathology.
|
26518018 |
2015 |
|
Frontotemporal Lobar Degeneration
|
|
0.010 |
GeneticVariation
|
BEFREE |
This variant is in high LD with the TMEM106B non-synonymous variant p.T185S (rs3173615; r<sup>2</sup> = 0.98) which was previously identified as a protective variant for frontotemporal lobar degeneration (FTLD).
|
31456032 |
2020 |
|
Neurodegenerative Disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
Eighty-six deceased male athletes with a history of participation in American football, informant-reported Caucasian, and a positive postmortem diagnosis of CTE without comorbid neurodegenerative disease were genotyped for rs3173615.
|
30390709 |
2018 |
|
Muscle Rigidity
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this Chinese patient population, "GG" of rs363371 in VMAT2 may reduce the risk for SALS, while minor alleles of rs1990622 and rs3173615 in TMEM106B may be associated with PD patients with initial symptom of rigidity/bradykinesia.
|
28477711 |
2017 |
|
Tremor
|
|
0.010 |
GeneticVariation
|
BEFREE |
The frequencies of minor alleles for rs1990622 and rs3173615 in TMEM106B were significantly different between PD patients with initial symptoms of tremor and rigidity/bradykinesia (p=0.001), and between patients with initial symptom of rigidity/bradykinesia and HCs (p<0.001).
|
28477711 |
2017 |
|
Parkinson Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Recent studies found that two polymorphisms (rs363371 and rs363324) in VMAT2 might be a risk factor for Parkinson's disease (PD) in Caucasians, while the two other variants (rs1990622 and rs3173615) in TMEM106B increased the risk for frontotemporal dementia (FTD).
|
28477711 |
2017 |
|
Bradykinesia
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this Chinese patient population, "GG" of rs363371 in VMAT2 may reduce the risk for SALS, while minor alleles of rs1990622 and rs3173615 in TMEM106B may be associated with PD patients with initial symptom of rigidity/bradykinesia.
|
28477711 |
2017 |
|
Motor Neuron Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
We assessed the genotype of 325 C9ORF72 expansion carriers (cohort 1), 586 FTD patients lacking C9ORF72 expansions [with or without motor neuron disease (MND); cohort 2], and a total of 1,302 controls for TMEM106B variants (rs3173615 and rs1990622) using MassArray iPLEX and Taqman genotyping assays.
|
24385136 |
2014 |
|
Pick Disease of the Brain
|
|
0.010 |
GeneticVariation
|
BEFREE |
TMEM106B p.T185S regulates TMEM106B protein levels: implications for frontotemporal dementia.
|
23742080 |
2013 |