Obesity
|
|
0.090 |
GeneticVariation
|
BEFREE |
This may explain the greater vulnerability for addiction and obesity in individuals with C385A genetic variant and by extension, suggest that a D3 antagonism strategy in substance use disorders should consider FAAH C385A polymorphism.
|
31775159 |
2020 |
Obesity
|
|
0.090 |
GeneticVariation
|
BEFREE |
The influence of the fatty acid amide hydrolase 385C>A single nucleotide polymorphisms on obesity susceptibility.
|
31286394 |
2019 |
Obesity
|
|
0.090 |
GeneticVariation
|
BEFREE |
The FAAH SNP rs324420 was associated with increased obesity (three studies).
|
30129173 |
2019 |
Obesity
|
|
0.090 |
GeneticVariation
|
BEFREE |
It has been demonstrated that the polymorphism 385 C/A of FAAH (fatty acid amide hydrolase) was associated with obesity and metabolic disorders.
|
22609216 |
2013 |
Obesity
|
|
0.090 |
GeneticVariation
|
BEFREE |
As we observed some evidence for an association of the FAAH variants rs2295632 rs324420 with early onset but not adult obesity, we conclude that the FAAH variants analyzed here at least do not seem to play a major role in the etiology of obesity within our samples.
|
20044928 |
2010 |
Obesity
|
|
0.090 |
GeneticVariation
|
BEFREE |
It has been demonstrated that the polymorphism 385 C/A of fatty acid amide hydrolase was associated with obesity.
|
20102775 |
2010 |
Obesity
|
|
0.090 |
GeneticVariation
|
BEFREE |
The aim of our study was to investigate the relationship of polymorphism (cDNA 385 C-->A) of FAAH gene on obesity parameters in patients with diabetes mellitus type 2.
|
20056290 |
2010 |
Obesity
|
|
0.090 |
GeneticVariation
|
BEFREE |
An association between Pro129Thr variant of the FAAH gene and obesity has been described, but various studies have yielded conflicting results.
|
18819056 |
2008 |
Obesity
|
|
0.090 |
GeneticVariation
|
BEFREE |
Our results in 5,109 subjects suggest that FAAH Pro129Thr polymorphism may modestly contribute to class III adult obesity in the French population.
|
20054193 |
2008 |
Addictive Behavior
|
|
0.050 |
GeneticVariation
|
BEFREE |
This may explain the greater vulnerability for addiction and obesity in individuals with C385A genetic variant and by extension, suggest that a D3 antagonism strategy in substance use disorders should consider FAAH C385A polymorphism.
|
31775159 |
2020 |
Addictive Behavior
|
|
0.050 |
GeneticVariation
|
BEFREE |
The common functional single-nucleotide polymorphism (rs324420, C385A) of the endocannabinoid inactivating enzyme fatty acid amide hydrolase (FAAH) has been associated with anxiety disorder relevant phenotype and risk for addictions.
|
26036940 |
2015 |
Overweight and obesity
|
|
0.050 |
GeneticVariation
|
BEFREE |
C385A is a common, functionally active genetic polymorphism of the gene encoding fatty acid amide hydrolase and has been associated with overweight and obesity.
|
23616186 |
2013 |
Overweight and obesity
|
|
0.050 |
GeneticVariation
|
BEFREE |
The Pro129THr, C385A, polymorphism of FAAH gene (rs324420C>A) has been associated with overweight and obesity.
|
20716455 |
2011 |
Overweight and obesity
|
|
0.050 |
GeneticVariation
|
BEFREE |
The Pro129THr, C385A, polymorphism of FAAH gene (rs324420C>A) has been associated with overweight and obesity.
|
20716455 |
2011 |
Overweight and obesity
|
|
0.050 |
GeneticVariation
|
BEFREE |
Recently, it has been shown that the polymorphism 385 C/A of FAAH (fatty acid amide hydrolase) was associated with overweight and obesity.
|
20065978 |
2010 |
Overweight and obesity
|
|
0.050 |
GeneticVariation
|
BEFREE |
The polymorphism 385 C/A of FAAH has been associated with overweight and obesity.
|
20056290 |
2010 |
Addictive Behavior
|
|
0.050 |
GeneticVariation
|
BEFREE |
A common single nucleotide polymorphism (C385A) in the human FAAH gene has been associated with increased risk for addiction and obesity.
|
19103437 |
2009 |
Overweight and obesity
|
|
0.050 |
GeneticVariation
|
BEFREE |
We investigated the Pro129Thr variant in relation to overweight and obesity in a relatively large population-based study sample of Danish whites (n=5,801).
|
17216208 |
2007 |
Addictive Behavior
|
|
0.050 |
GeneticVariation
|
BEFREE |
Moreover, this mutation appears to have arisen early in human evolution and this study validates the previous link between the FAAH P129T variant and vulnerability to addiction of multiple different drugs.
|
16972078 |
2006 |
Addictive Behavior
|
|
0.050 |
GeneticVariation
|
BEFREE |
This SNP, which converts a conserved proline residue in FAAH to threonine (P129T), suggests a potential role for the FAAH-endocannabinoid system in regulating addictive behavior.
|
15254019 |
2004 |
Drug usage
|
|
0.040 |
GeneticVariation
|
BEFREE |
In this study we investigated inter-individual differences in mood response to amphetamine in relation to four polymorphisms in the FAAH gene, including the FAAH missense variant rs324420C --> A (Pro129Thr), which was previously found to be associated with street drug use and addictive traits.
|
19890266 |
2010 |
Drug usage
|
|
0.040 |
GeneticVariation
|
BEFREE |
The fatty acid amide hydrolase C385A (P129T) missense variant in cannabis users: studies of drug use and dependence in Caucasians.
|
17290447 |
2007 |
Drug usage
|
|
0.040 |
GeneticVariation
|
BEFREE |
The human fatty acid amide hydrolase (FAAH) missense mutation c.385 C-->A, which results in conversion of a conserved proline residue to threonine (P129T), has been associated with street drug use and problem drug abuse.
|
16972078 |
2006 |
Drug usage
|
|
0.040 |
GeneticVariation
|
BEFREE |
Reduced cellular expression and activity of the P129T mutant of human fatty acid amide hydrolase: evidence for a link between defects in the endocannabinoid system and problem drug use.
|
15254019 |
2004 |
Anxiety Disorders
|
|
0.030 |
GeneticVariation
|
BEFREE |
Here, we provide clinical translation for the importance of these molecular interactions using an imaging genetics strategy to examine whether interactions between genetic polymorphisms associated with differential anandamide (FAAH rs324420) and CRF1 (CRHR1 rs110402) signaling modulate amygdala function and anxiety disorder diagnosis.
|
26923505 |
2016 |